DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PMCA and Atp2b4

DIOPT Version :9

Sequence 1:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster
Sequence 2:	XP_038946574.1	Gene:	Atp2b4 / 29600	RGDID:	621305	Length:	1241	Species:	Rattus norvegicus

Alignment Length:	1287	Identity:	727/1287 - (56%)
Similarity:	885/1287 - (68%)	Gaps:	130/1287 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QYGISLKQLRELMEHRGREGVMKI-AENGGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVI 73
            ::|.:|..||:|||.|..:.|.:| |..|.:.|:|.:|.|||.|||||:.||.|.||..||.|:|
  Rat    21 EFGCTLMDLRKLMELRAADAVTQISAHYGSVQEICARLKTSPVEGLSGNPADLEKRRLVFGKNMI 85

  Fly    74 PPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVL--------QEEEEHHGWI 130
            |||.|||||.|||||||||||||||:||::||.||||:|...:..:.        ::||...|||
  Rat    86 PPKKPKTFLELVWEALQDVTLIILEIAAIISLVLSFYRPPGGENEICGHIVSNPEEDEEGETGWI 150

  Fly   131 EGLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVK 195
            ||.|||.|||:||.||||||:|||:||||||:|||.|.|||:||.|::.|:.|.:|:||||||||
  Rat   151 EGAAILASVIIVVFVTAFNDWSKEKQFRGLQSRIELEQKFSIIRNGQLIQLPVAEIVVGDIAQVK 215

  Fly   196 YGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVNSQA 260
            |||||||||.|||.||||:||||||||||||||..|.|||:|||||||||||:|||||||:|||.
  Rat   216 YGDLLPADGILIQGNDLKIDESSLTGESDHVKKTLDKDPMLLSGTHVMEGSGRMVVTAVGINSQT 280

  Fly   261 GIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSES 325
            |||||||||..:|.:.:.||.||:....|:.|..|  .||               |..||....|
  Rat   281 GIIFTLLGANEEEDDEKKKKGKKQGVSENRNKAKT--QDG---------------VALEIQPLNS 328

  Fly   326 -EGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDE 389
             ||  |........|..|.||||||||.|||:||:|||.||..:::|||:|||:.|.:..|||..
  Rat   329 QEG--LDSEEKEKKASKGPKKEKSVLQGKLTRLAVQIGKAGLIMSILTVLILILYFVVDNFVIQR 391

  Fly   390 KPW----KNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETM 450
            :.|    ...|....||..||||||||||||||||||||:|||||||||||||||||||||||||
  Rat   392 RAWLPECTPVYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETM 456

  Fly   451 GNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISVNSAYTSNIMAG 515
            |||||||||||||||.|||||||:||.....:.:|...|:|.:|.:||...|.:||||||.|:..
  Rat   457 GNATAICSDKTGTLTMNRMTVVQAYIGGTHYRQIPKPDDLPPNVLDLIVNSICINSAYTSKILPP 521

  Fly   516 HNPGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSMGTVIPRPNGGY 580
            ...|.||.||||||||.|||||..|...||::|.|:.|:|..:|||||||||||.|||.:|.||:
  Rat   522 EKEGGLPRQVGNKTECGLLGFVTDLKQDYQAVRSEMPEEKLFKVYTFNSVRKSMSTVIRKPEGGF 586

  Fly   581 RLYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISVAYRDFVPGKAA 645
            |:::||||||:::||..|...||.:..|....::.::|.||||||.:|||||.:|||||
  Rat   587 RVFSKGASEIMLRKCDRILNKEGGIVPFKTKDRDNMVRNVIEPMASEGLRTIGIAYRDF------ 645

  Fly   646 INEVHIDG-EPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTAR 709
                  || ||:|::|..|.|.|.|:.||||||||||||||||.||:|||||||||||||:||||
  Rat   646 ------DGEEPSWENENEIFTGLVCIAVVGIEDPVRPEVPDAINKCKRAGITVRMVTGDNVNTAR 704

  Fly   710 SIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGII 774
            :||:|||||.|.||||.||||||||.||:..|:::|..:|||||:||||||||||||:|||||||
  Rat   705 AIATKCGILTPGDDFLCLEGKEFNRLIRNEKGEVEQEKLDKVWPRLRVLARSSPTDKHTLVKGII 769

  Fly   775 DSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGR 839
            ||.:.|.|:|||||||||||||||||||||||||||||||||||||||||||||:||||||||||
  Rat   770 DSNIGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGR 834

  Fly   840 NVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDL 904
            ||||||:||||||||||||||||||.|||..|||||||||||||||||||.||||||||.||..|
  Rat   835 NVYDSISKFLQFQLTVNVVAVIVAFSGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTDSL 899

  Fly   905 LLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIESGRGQELNAGPTQHFTIIF 969
            |.|:||||.||||||||||||||.|:|||.|:|.|:|.||.:.||:|||...||:.|:||:||:|
  Rat   900 LRRRPYGRNKPLISRTMMKNILGHAVYQLGIVFLLVFAGDKLFDIDSGRKAPLNSPPSQHYTIVF 964

  Fly   970 NTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAFSTKALTLDQW 1034
            ||||:|.||||||:|||||::||..|:..|.||.::.:.|...|:||::.|...||...||::||
  Rat   965 NTFVLMQLFNEINSRKIHGEKNVFAGVYRNIIFCSVVLGTFFCQILIVEVGGKPFSCTNLTMEQW 1029

  Fly  1035 LWCIFFGIGTLVWGQLITSVPTRKLPKILSWGRGHPEEYTDGMNLGEERFDSID-SDKKPRAGQI 1098
            :||:|.|||.|:|||:|:::||:.|..:...|.|..:|   .::...|..:.|| ::.:.|.|||
  Rat  1030 MWCLFIGIGELLWGQVISAIPTKSLKFLKEAGHGSDKE---EISKDAEGLEEIDHAEMELRRGQI 1091

  Fly  1099 LWIRGLTRLQTQLRVIRAFR--STLEDLNERRSMHSLHSLRSPRTGIPVAVGGGHPLYNFNLLNP 1161
            ||:|||.|:|||:.||..|:  ::.:.:..|:::
  Rat  1092 LWVRGLNRIQTQIEVINKFQTGASFKGVLRRQNL------------------------------- 1125

  Fly  1162 NYIKHQQQQEPKLPP-----------------------QTQLNVSSGMMSPDISYIDEDPQQQQR 1203
                 .||.:.||.|                       :.|:::.|.|..|:.:..||
  Rat  1126 -----SQQLDVKLVPSSYSEAIRVVKVFHSFRDVIHKSKNQVSIHSFMTQPEYAADDE------- 1178

  Fly  1204 TLHNGLTSQRSSMPSNVPSSNQSFSKIAQTLQQKIRGNIETKHSNGQNETRI 1255
             :.....:|..|      .|..|.|:|.:.|     .:.||...|..|...:
  Rat  1179 -MSQSFLNQEES------PSLASKSRITKRL-----SDAETVSQNNTNNNAV 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	680/1061 (64%)
		Cation_ATPase_N	36..104	CDD:279080	46/67 (69%)
		E1-E2_ATPase	172..448	CDD:278548	170/280 (61%)
		Cation_ATPase	505..598	CDD:289987	56/92 (61%)
		HAD_like	676..807	CDD:119389	105/130 (81%)
		Cation_ATPase_C	873..1051	CDD:279079	114/177 (64%)
		ATP_Ca_trans_C	1096..1142	CDD:289209	16/47 (34%)
Atp2b4	XP_038946574.1	ATPase-IIB_Ca	16..1052	CDD:273668	680/1061 (64%)
Atp2b4	XP_038946574.1	ATP_Ca_trans_C	1089..1172	CDD:403580	24/118 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352199
Domainoid	1	1.000	256	1.000	Domainoid score	I1961
eggNOG	1	0.900	-	-		E2759_KOG0204
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1376	1.000	Inparanoid score	I115
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D115892at2759
OrthoFinder	1	1.000	-	-		FOG0000362
OrthoInspector	1	1.000	-	-		otm44563
orthoMCL	1	0.900	-	-		OOG6_100143
Panther	1	1.100	-	-	O	PTHR24093
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X220
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770