DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PMCA and Atp1a4

DIOPT Version :9

Sequence 1:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster
Sequence 2:	NP_001257959.1	Gene:	Atp1a4 / 29132	RGDID:	61952	Length:	1028	Species:	Rattus norvegicus

Alignment Length:	1173	Identity:	295/1173 - (25%)
Similarity:	467/1173 - (39%)	Gaps:	332/1173 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LKQLRELMEHRGREGVM---KIAENGGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVIPPK 76
            :|:.::.:|...:|.||   |:.    :.||..|......:|||.:.|.|.....  |.||:.|
  Rat    30 VKRRKKDLEELKKEVVMDDHKLT----LDELSAKYSVDLTKGLSVTDAQEILTLN--GPNVLTP- 87

  Fly    77 PPKT-------------FLTLVWEALQDVTLIILEVAALVSLGL--SFYKP-ADEDAPVLQEEEE 125
            ||.|             |..|:|..         .:...::.|:  |:|:. |::|...
  Rat    88 PPTTPEWIKFCKQLFGGFSLLLWTG---------SLLCFLAYGIHVSYYQENANKDNLY------ 137

  Fly   126 HHGWIEGLAILISVIVVVIVTAFNDYSKERQFRGLQN-RIEGEHKFSVIRGGEVCQISVGDILVG 189
                   |.|::|. ||:|...|:.|.:.:..:.::: :.....:..|||.||..||:|.|:::|
  Rat   138 -------LGIVLSA-VVIITGCFSYYQEAKSSKIMESFKTMVPQQALVIRDGEKMQINVRDVVLG 194

  Fly   190 DIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDV---DPM-----VLSGTHVMEGS 246
            |:.:||.||.:|||..:|.:...|||.|||||||:...:.||.   :|:     :...|:.:||:
  Rat   195 DLVEVKGGDQVPADIRVIAAQGCKVDNSSLTGESEPQSRCPDCTHENPLETRNIIFFSTNCVEGT 259

  Fly   247 GKMVVTAVGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPS 311
            .:.||.|.|.::..|.|.:|
  Rat   260 ARGVVIATGDHTVMGRIASL--------------------------------------------- 279

  Fly   312 QRETVTSEITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIIL 376
                 ||.:|..:                              |.:|.:|.:....|..:.|.:.
  Rat   280 -----TSGLTMGK------------------------------TPIATEIEHFIHIITAVAVFLG 309

  Fly   377 IIQFCIKTFVIDEKPWKNTYANNLVKHLIIGVT----------VLVVAVPEGLPLAVTLSLAYSV 431
            :..|.:.                    ||:|.|          ::|..|||||...||:.|..:.
  Rat   310 VTFFFLS--------------------LILGYTWLDAVIFLIGIIVANVPEGLLATVTVCLTLTA 354

  Fly   432 KKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLC-----------KVLP 485
            |:|.:.|.||::|:|.||:|:.:.||||||||||.|||||...:..:.:.           |..|
  Rat   355 KRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWFDKTVYEADTSEEQTTGKTFP 419

  Fly   486 TLSDIPQHVGNLITMGISVNSAYTSNIMAGHNPGD-------LPI----QVGNKTECALLGFVQG 539
            ..||               ...|.:.|....|..|       |||    ..|:.:|.|||.|::
  Rat   420 KSSD---------------TWFYLARIAGLCNRADFKPHQESLPITKRTTTGDASESALLKFIE- 468

  Fly   540 LGVKYQSIRDEITEDKFTRVYTFNSVRK-SMGTVIPRPNG-GYRLYTKGASEIIMKKCA--FIYG 600
              ..|..:.:...::.......|||..| .|...:...|. .:.|..|||.|.|:..|:  .:.|
  Rat   469 --QSYSPVSEMRQKNPKVAEIPFNSTNKYQMSIHLLEDNSEAHVLLMKGAPERILDFCSSFLLNG 531

  Fly   601 HEGTL-EKFTRDMQERLIREVIEPMACDGLRTISVAYRDFVPGKAAINEVHIDGEPNWD------ 658
            .|..: |:...|.|...|.       ..||            |:..:....::...|:.
  Rat   532 QEYPMDEEMKTDFQNAYIE-------LGGL------------GERVLGFCFLNLPSNFSKGFQFN 577

  Fly   659 -DEENI-MTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPN 721
             :|.|. |.||....::.:.||.|..||||:.||:.|||.|.|||||:..||::||...||:...
  Rat   578 TEELNFPMENLCFAGLISMIDPPRTAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEA 642

  Fly   722 DD----------------------FLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLR--VLARSS 762
            ::                      .:::.|.|..        |:....:|.:....:  |.||:|
  Rat   643 NETAEDIAARLNISISQVSNKSIKAIVVHGSELK--------DMDSGQLDNILKSYKEIVFARTS 699

  Fly   763 PTDKYTLVKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDN 827
            |..|..:|:|     ......:|||||||.||.|||||||:|.||||.|:||:|:|:|:||.|||
  Rat   700 PQQKLIIVEG-----CQRLGAIVAVTGDGVNDSPALKKADIGIAMGITGSDVSKQAADMILLDDN 759

  Fly   828 FSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLAS 892
            |:|||..|..||.::|::.|.:.:.||.|:..:....:........||..:.:|.::|..|.:.:
  Rat   760 FASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIVLSIPLPLGTITILCIDLGTDMVPA 824

  Fly   893 LALATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIESGRGQEL 957
            ::||.|.|..|::.|.|   ..|.....:...::|.|..|:.:|..|
  Rat   825 ISLAYETPESDIMKRLP---RNPKTDNLVNDRLIGMAYGQIGMIQAL------------------ 868

  Fly   958 NAGPTQHFTIIF-NTFVMMTL------FNEINARKI---------HGQRNVIEGLLTNPIFYTI- 1005
             ||...:|.|:. |.|..:.|      :::.|...:         :.||.|:|.......|.:|
  Rat   869 -AGFFTYFVILAENGFKPLDLLGIRLYWDDTNLNDLEDTYGQQWTYEQRKVVEFTCQTAFFISIV 932

  Fly  1006 ---WIFTMISQVLIIQYGKMAFSTKALTLDQWLWCIFFGIGTLVWGQLITSVP-----TRKLPKI 1062
               |...:|.:.......|.....|.|        ||..:...:....::.:|     .|..|..
  Rat   933 IVQWADLIICKTRRNSLFKQGMKNKVL--------IFGLLEETILAACLSYIPGMDVALRMYPLK 989

  Fly  1063 LSW 1065
            ::|
  Rat   990 INW 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	292/1163 (25%)
		Cation_ATPase_N	36..104	CDD:279080	18/80 (23%)
		E1-E2_ATPase	172..448	CDD:278548	71/293 (24%)
		Cation_ATPase	505..598	CDD:289987	27/107 (25%)
		HAD_like	676..807	CDD:119389	53/154 (34%)
		Cation_ATPase_C	873..1051	CDD:279079	39/197 (20%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
Atp1a4	NP_001257959.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		1/5 (20%)
		ATPase-IIC_X-K	32..1028	CDD:273445	294/1171 (25%)
		Cation_ATPase_N	46..119	CDD:214842	20/88 (23%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	87..89		1/2 (50%)
		E1-E2_ATPase	140..371	CDD:278548	78/331 (24%)
		Cation_ATPase	434..526	CDD:289987	25/94 (27%)
		COG4087	608..757	CDD:226572	58/161 (36%)
		Cation_ATPase_C	804..1013	CDD:279079	43/219 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010