DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PMCA and atp2a1

DIOPT Version :9

Sequence 1:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster
Sequence 2:	NP_001007030.1	Gene:	atp2a1 / 260440	ZFINID:	ZDB-GENE-020905-1	Length:	994	Species:	Danio rerio

Alignment Length:	1080	Identity:	300/1080 - (27%)
Similarity:	472/1080 - (43%)	Gaps:	223/1080 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 SPNEGLSGSKADEEHRRETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPA 113
            |.:.||:..:..:...:  :|.|.:|.:..|:...||.|..:|:.:.||.:||.:|..|::::
Zfish    19 SESTGLTPEQVKKNQAK--YGFNELPAEEGKSIWELVVEQFEDLLVRILLLAACISFVLAWFE-- 79

  Fly   114 DEDAPVLQEEEEHHGWIEGLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGE- 177
                   :.||....::|...||:.:|...:|..:.:.:.|.....|:   |.|.:...:...:
Zfish    80 -------EGEETVTAFVEPFVILLILIANAVVGVWQERNAESAIEALK---EYEPEMGKVYRSDR 134

  Fly   178 --VCQISVGDILVGDIAQVKYGDLLPADGCL--IQSNDLKVDESSLTGES----DHVKKGPDVDP 234
              |.:|...:|:.|||.:|..||.:|||..:  |:|..|:||:|.|||||    .|.:..|  ||
Zfish   135 KSVQRIKAREIVPGDIVEVSVGDKVPADIRITAIRSTTLRVDQSILTGESVSVIKHTESVP--DP 197

  Fly   235 ---------MVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANK 290
                     |:.|||::..|....||.|.||:::.|.|
Zfish   198 RAVNQDKKNMLFSGTNIAAGKAIGVVVATGVSTEIGKI--------------------------- 235

  Fly   291 QKNLTGENDGRSQIKGSQAPSQRETVTSEITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLT 355
                      |.|:..::                                    :||:.||.||.
Zfish   236 ----------RDQMAATE------------------------------------QEKTPLQQKLD 254

  Fly   356 KLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEKPWKNTYANNLVKHLIIGVTVLVVAVPEGLP 420
            :...|:....|.|.|...:|.|..|       ::.....::....|.:..|.|.:.|.|:|||||
Zfish   255 EFGEQLSKVISLICVAVWLINIGHF-------NDPVHGGSWIRGAVYYFKIAVALAVAAIPEGLP 312

  Fly   421 LAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLP 485
            ..:|..||...::|.|.|.:||.|.:.||:|..:.||||||||||||:|.|.:.::.||:.....
Zfish   313 AVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMCVTKMFVIEKVEGESV 377

  Fly   486 TLS--DI------PQHVGNLITMGISVNSAY------TSNIMAGHNPGDLPI--------QVGNK 528
            ||.  ||      |:  |.:...|:.|....      .:.|.|..|...|..        :||..
Zfish   378 TLDQYDISGSKYTPE--GEVTKNGLPVKCGQFDGLVELATICALCNDSSLDYNESKGIYEKVGEA 440

  Fly   529 TECALLGFVQGLGVKYQSIR---------------DEITEDKFTRVYTFNSVRKSMGTVIPRPNG 578
            ||.||...|:.:.|....:|               .::.:..||  ..|:..||||.........
Zfish   441 TETALCCLVEKMNVFNTDVRGLSKVERANTCCAVIKQLMKKDFT--LEFSRDRKSMSVYCSPAKA 503

  Fly   579 -----GYRLYTKGASEIIMKKCAFIYGHEGTLE-KFTRDMQERLIREVIE-PMACDGLRTISVAY 636
                 |.:::.|||.|.::.:||::  ..||.. ..|..::::::..:.| ....|.||.:::|.
Zfish   504 SKAPVGNKMFVKGAPEGVIDRCAYV--RVGTTRVPLTGPVKDKIMAVIKEWGTGRDTLRCLALAT 566

  Fly   637 RDFVPGKAAINEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVT 701
            ||   ......|::::....:.:.|   |:||.:..||:.||.|.||..:|..|:.|||.|.|:|
Zfish   567 RD---NPLRPEEMNLEDSTKFAEYE---TDLTFVGCVGMLDPPRKEVVGSIELCRAAGIRVIMIT 625

  Fly   702 GDNINTARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDK 766
            |||..||.:|..:.||...::|   :.|:.|..|..|.....||.   :...|....||..|:.|
Zfish   626 GDNKGTAVAICRRIGIFSDDED---VTGRAFTGREFDDLPLPQQR---EAVRKACCYARVEPSHK 684

  Fly   767 YTLVKGI--IDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFS 829
            ..:|:.:  .|       |:.|:||||.||.||||||::|.||| :||.|||.||:::|.|||||
Zfish   685 SKIVEFLQGFD-------EITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSASEMVLADDNFS 741

  Fly   830 SIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLA 894
            |||.||..||.:|:::.:|:::.::.||..|:..|:.|.......|..||:|||||:.|.|.:.|
Zfish   742 SIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATA 806

  Fly   895 LATEFPTPDLLLRKPYGRTKPLISRTMMKNIL------GQA---------LY----QLIIIFGLL 940
            |....|..|::.:.|....:||||..:....|      |.|         ||    .::..:.|.
Zfish   807 LGFNPPDLDIMGKAPRSPKEPLISGWLFFRYLAIGGYVGAATVAAAGWWFLYCDEGPMVSFYQLS 871

  Fly   941 FVGDVILDIESGRGQE---LNAGPTQHFTIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIF 1002
            .......|.|...|.|   ..|.|.  .|:..:..|.:.:.|.:|:...:      :.||..|.:
Zfish   872 HFMQCTADNEDFAGIECEVFEAAPP--MTMALSVLVTIEMCNALNSLSEN------QSLLRMPPW 928

  Fly  1003 YTIWI-----FTMISQVLIIQYG--KMAFSTKALTLDQWL 1035
            ..:|:     .:|....:||...  .|.|....|..|||:
Zfish   929 SNLWLAGAMTLSMSLHFMIIYVDPLPMIFKLTHLNFDQWI 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	300/1080 (28%)
		Cation_ATPase_N	36..104	CDD:279080	15/54 (28%)
		E1-E2_ATPase	172..448	CDD:278548	73/293 (25%)
		Cation_ATPase	505..598	CDD:289987	27/126 (21%)
		HAD_like	676..807	CDD:119389	50/132 (38%)
		Cation_ATPase_C	873..1051	CDD:279079	48/192 (25%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
atp2a1	NP_001007030.1	Cation_ATPase_N	4..72	CDD:279080	15/54 (28%)
		ATPase-IIA1_Ca	53..989	CDD:273452	292/1044 (28%)
		E1-E2_ATPase	93..340	CDD:278548	81/331 (24%)
		Cation_ATPase	419..528	CDD:289987	25/110 (23%)
		HAD	<604..712	CDD:289480	43/120 (36%)
		Cation_ATPase_C	784..987	CDD:279079	48/193 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010