Protein Alignment PMCA and pmc1

DIOPT Version :10

• Sequence 1: NP_001014689.3
• Gene: PMCA / 43787
• FlyBaseID: FBgn0259214
• Length: 1255
• Species: Drosophila melanogaster
• Sequence 2: NP_593890.1
• Gene: pmc1 / 2543477
• PomBaseID: SPAPB2B4.04C
• Length: 1292
• Species: Schizosaccharomyces pombe
• Alignment Length: 1307
• Identity: 465/1307 - (35%)
• Similarity: 653/1307 - (49%)
• Gaps: 287/1307 - (21%)

  Fly     9 AQYGISLKQLRELMEHRGREGVMKIAENGGIHELCKKLYTSPNEGLSGSK---AD---------- 60
            |.:..|:..|:.|.:.:....:..|   .|:..|||.|...|:.|:|..:   ||
pombe   117 APFAFSIPLLQRLQDPKNTSLLHAI---HGLKGLCKGLKVDPSTGISTHEPHYADKLQMSDILND 178

  Fly    61 --------------------------EEHRRETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEV 99
                                      :..|.:.:|.||:|....|..:.|:.||.:|..||:|.:
pombe   179 DSNPKLVVHLDRIRSQDNNPEAKVSHDSDRVKYYGKNVLPEHDSKGLIRLMLEAFKDKVLILLSI 243

  Fly   100 AALVSLGLSFY----KPADEDAPVLQEEEEHHGWIEGLAILISVIVVVIVTAFNDYSKERQFRGL 160
            ||:|||.|..|    :|...| |:..:.|....|:||:||:.::::||.|...||:.||.||:.|
pombe   244 AAVVSLALGLYQTFGQPPTLD-PITGKPEPRVEWVEGVAIMAAIVIVVTVGGVNDWQKELQFKKL 307

  Fly   161 QNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDH 225
            ..:: ......|:|.|.|...||.|::|||:..|:.||::|.||.||:||:|.:|||::|||:|:
pombe   308 NAKV-SNFDVQVLRDGAVHSTSVFDLVVGDVLFVEAGDVVPVDGVLIESNNLVLDESAMTGETDN 371

  Fly   226 VKK----------GPDV------DPMVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGAAVDEQ 274
            :||          .|||      ||.::|||.::||:||::||||||||..|
pombe   372 IKKVDANTAIERTSPDVEYRKNADPYLISGTTILEGNGKLLVTAVGVNSFNG------------- 423

  Fly   275 EAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSESEGNHLPQSSSSGAA 339
                                                  |.|:.     ..:||...|
pombe   424 --------------------------------------RTTMA-----MRTEGQATP-------- 437

  Fly   340 ETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEKPWKNTYANNLVKHL 404
                      ||.:|:::|..|...|...:.|..|:|:|:|.::....|... ||. ....::.|
pombe   438 ----------LQLRLSRVADAIAKLGGAASALLFIVLLIEFLVRLKSNDSSS-KNK-GQEFLQIL 490

  Fly   405 IIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRM 469
            |:.||:|||||||||||||||:||::..:|.|||||||||.||||||.||.||||||||||.|||
pombe   491 IVSVTLLVVAVPEGLPLAVTLALAFATNRMQKDNNLVRHLQACETMGTATNICSDKTGTLTQNRM 555

  Fly   470 TVV-----------------------------------QSYICEKLCKVLPTLSDIPQHVGNLIT 499
            |||                                   .::..::|.   |.|.|       |..
pombe   556 TVVAGGFGTDVLFFDHNDETPTNVDQGSDSSKFEDAGASAFAFKRLS---PELRD-------LTL 610

  Fly   500 MGISVNSAYTSNIMAGHNPGDLPIQVGNKTECALLGF-VQGLGV-KYQSIRDEITEDKFTRVYTF 562
            ..|:|||  |...:...| .|.|..:|:|||.|||.. |:.||: ...|:|..:...:|   ::|
pombe   611 YSIAVNS--TCRQLFEDN-SDTPRFIGSKTETALLDMSVKELGLTNVDSMRSSVDIKQF---FSF 669

  Fly   563 NSVRKSMGTVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQER--LIREVIEPMA 625
            :|.||:.|.:....: .|....||..|.::::...:..: |:|:: ..||...  ..:|:|...|
pombe   670 SSDRKASGAIFEYKD-KYYFVVKGMPERVLQQSTSVITN-GSLDE-VEDMHSHADYFKEMITGYA 731

  Fly   626 CDGLRTISVAYRDF---VPGKAAINEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAI 687
            ...|||:.:.||.|   .|.....|:........|:|   ..|::|.|...||.||:||:||.|:
pombe   732 KRSLRTLGLCYRVFDSWPPKDIPTNDEDSSNPLKWED---AFTDMTFLGFFGIMDPIRPDVPLAV 793

  Fly   688 RKCQRAGITVRMVTGDNINTARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVW 752
            :.||.||:||||||||||.||::|||:|||.  .:|.:.:||.|| |.:.|     ::.|  ::.
pombe   794 KVCQGAGVTVRMVTGDNIVTAKAIASQCGIY--TEDGISMEGPEF-RSLSD-----EKRL--EIL 848

  Fly   753 PKLRVLARSSPTDKYTLVKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKE 817
            |||.|||||||.||..|::|:     .:...|||||||||||.||||||:|||:||.:||:||||
pombe   849 PKLDVLARSSPLDKQLLIEGL-----QKLGNVVAVTGDGTNDAPALKKANVGFSMGKSGTEVAKE 908

  Fly   818 ASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAV--QDSPLKAVQM 880
            ||||||.||||||||||:.|||.|.|::.||||||:|||:.||.:..|.|.|.  |.|.|.|||:
pombe   909 ASDIILMDDNFSSIVKAIAWGRTVNDAVKKFLQFQITVNITAVFLTIISAVASTDQSSVLTAVQL 973

  Fly   881 LWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDV 945
            |||||||||||:|||||:.|||::|.|||......|.:..|.|.|:.|::|||.:...|.|.|:.
pombe   974 LWVNLIMDTLAALALATDPPTPEVLKRKPEKPGASLFTFDMWKMIICQSMYQLAVTLVLHFAGNS 1038

  Fly   946 ILDIESGRGQELNAGPTQHFTIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTM 1010
            |....|... ::|       ||:|||||.:.||||||.|::..:.|:.|.:..|.:|..|::...
pombe  1039 IFHYPSNTA-DMN-------TIVFNTFVWLQLFNEINNRRLDNKLNIFERINHNFLFIAIFVIVA 1095

  Fly  1011 ISQVLIIQYGKMAFSTKALTLDQWLWCIFFGIGTLVWGQLITSVPTRKLPKIL---------SW- 1065
            ..||:|:.:|..|||.|.:....|...|.||:.::..|.||..||...|.|:|         ||
pombe  1096 GIQVIIVFFGGAAFSVKRIDGKGWAISIVFGVISIPLGALIRCVPNNFLRKVLPVKTIDTVFSWI 1160

  Fly  1066 -------GRGHPEEYTDGMNL-------GEERFDSIDSDKKPRAGQILWIRGLTRLQTQLRVIRA 1116
                   .|...:...:.::|       ..|..|||    :...|.:..||| .|::..|...:
pombe  1161 LNPRFRSKRRSTDHDVESLSLIPYEPTSPNEVIDSI----RHSLGFVQRIRG-GRIRHLLNNSK- 1219

  Fly  1117 FRSTLEDLNER---RSMHSLHSLRSPRTG--------IPV------AVG--GGHPLYNFNLLNPN 1162
            |...:|.|.||   |.......:|||...        ||:      |.|  |||.:
pombe  1220 FDKQMEALPERLRPRVKQRFMKIRSPSVSSATSVALMIPISTLVSEASGRLGGHDI--------- 1275

  Fly  1163 YIKHQQQ 1169
            :|.|.:|
pombe  1276 WISHNRQ 1282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	P-type_ATPase_Ca_PMCA-like	62..921	CDD:319776	365/922 (40%)
		Cation_ATPase_C	873..1051	CDD:376368	74/177 (42%)
		ATP_Ca_trans_C	1096..1141	CDD:463575	15/47 (32%)
pmc1	NP_593890.1	P-type_ATPase_Ca_PMCA-like	206..1014	CDD:319776	365/922 (40%)
		Cation_ATPase_C	966..1137	CDD:376368	75/178 (42%)