Protein Alignment PMCA and catp-2

DIOPT Version :10

• Sequence 1: NP_001014689.3
• Gene: PMCA / 43787
• FlyBaseID: FBgn0259214
• Length: 1255
• Species: Drosophila melanogaster
• Sequence 2: NP_504328.1
• Gene: catp-2 / 182114
• WormBaseID: WBGene00015338
• Length: 1050
• Species: Caenorhabditis elegans
• Alignment Length: 1135
• Identity: 291/1135 - (25%)
• Similarity: 472/1135 - (41%)
• Gaps: 268/1135 - (23%)

  Fly    51 NEGLSGSKADEEHRRETFGSNVIPPKPPKT----------FLTLVWEALQDVTLIILEVAALVSL 105
            :.|||...|.|  |.|:.|.|.:  .|||.          |..|:|        |::..||.:||
 Worm    64 SRGLSKQVAAE--RLESDGRNAL--SPPKVISNWKLFLRQFKNLLW--------ILMFGAAALSL 116

  Fly   106 GLSFYKPADEDAPVLQEEEEHHGWIEGLAILISVIVVVIVTAFNDYSKERQ----FRGLQNRIEG 166
            ....|.|:|               :..|.:.|.:||::.|.....:.:|::    .|..|:.:
 Worm   117 VAYIYDPSD---------------LTNLCVGIFIIVIIFVMCIVSFFEEKKGVEVVRAFQSLM-- 164

  Fly   167 EHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPD 231
            .....|||.|....::..:::||||..|:.|..:|||..:|...|..::.||:|||::.::..
 Worm   165 PLSCQVIRDGVEQTLNPEELVVGDIVVVRSGCKVPADIRVIACTDFYLETSSITGEAEPLEFN-- 227

  Fly   232 VDPMVLSGTHVMEG-----SGKMVVTAVGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQ 291
             ..|....|.:.|.     :|...|...|.    ||:..
 Worm   228 -SAMADQKTSIFESYNIAFNGSFCVDGEGY----GIVIR-------------------------- 261

  Fly   292 KNLTGENDGRSQIKGSQAPSQRETVTSEITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTK 356
               |||                .||..:|                 |:.|..:||:.      .|
 Worm   262 ---TGE----------------RTVIGQI-----------------ASMTLDQKEQK------CK 284

  Fly   357 LAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEKPWKNTYANNLVKHLIIGVTVLVVA-VPEGLP 420
            ..::||.....|.|:.:|:.:|.|.:...:        ...::::::.:.|..::::| ||:|||
 Worm   285 FQVEIGRFVKFITVMAIIMAVIIFSVGLGI--------NKGHDVIRYFVTGFLMVIIANVPQGLP 341

  Fly   421 LAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVV-----QSYIC--- 477
            ..||..|....::|.|.|..::.|:..:::|..|.|.||||||||.|.|||.     .||..
 Worm   342 TTVTTELTIIARRMAKKNVFLKKLEKIDSVGATTLIASDKTGTLTKNCMTVTDLWYNNSYNSGRP 406

  Fly   478 ---EKLCKVLPTLSDIPQH-----VGNLITMGISVNSAYTSNIMAGHNPG-------DL------ 521
               .:..|...:::..|..     :.:|:::....|.|...|.:..:.|.       |:
 Worm   407 ENRRRSTKTRFSITSNPAQSFDAPLSDLLSVVCVCNKARIENTVTVNRPPPNVDSELDMSMYRIQ 471

  Fly   522 PIQ----VGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVY--TFNSVRK----------SMG 570
            |::    |||.:|.|||.:...: :..:.:|     :.|..|:  .||||||          :..
 Worm   472 PVKEMTIVGNPSEVALLRYASAM-LDAKELR-----ESFQVVFEIPFNSVRKYHLILATNKNTWN 530

  Fly   571 TVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISVA 635
            .|....:..:.:..|||.|:::|.|:.:..:..:.|...:.|::  ..|..|....:|.|.|..|
 Worm   531 QVDKNDDVEFVVMIKGAPEVLIKNCSTMNINGESKELDLKRMED--FNEAYEAFGDEGCRVIGFA 593

  Fly   636 YRDFVPGKAAINEVHIDGEP--NWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVR 698
            .:.|....:.:..:..:..|  :||          .|.:..|.||.|.:.|.||:.|:.|||.|.
 Worm   594 QKKFRARASTVFSLKSNTVPMEDWD----------FLGMSAIMDPPRDDTPKAIKACKAAGIKVY 648

  Fly   699 MVTGDNINTARSIASKCGILRPNDDFLILEGKEFNRRIRDSN-----GDIQQHLIDKVWPKLR-- 756
            |||||:.:||.:||.:.|::...:...:...::..||....:     |.....|..|.|.:|.
 Worm   649 MVTGDHKSTATAIARQIGMIDTEEVSRVDHNQQIIRRSNSQDWAVITGSELPALTQKQWDELLQH 713

  Fly   757 ---VLARSSPTDKYTLVKGIIDSTVSENR-EVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKE 817
               |.||::|..|..:|      |.|:.| |.|.|||||.||.|||||||||.|||:||:||||:
 Worm   714 RYIVFARTTPEHKLMIV------TESQKRGECVTVTGDGVNDAPALKKADVGVAMGLAGSDVAKQ 772

  Fly   818 ASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLT---VNVVAVIVAFIGACAVQDSPLKAVQ 879
            |:||||.||||||||..:..||.::|::.|.:.:.:.   ..:|.||:.|.....:..:|   ||
 Worm   773 AADIILLDDNFSSIVAGIEEGRLLFDNLRKTIAYTMAHMWPELVPVILNFFFGFPLGLTP---VQ 834

  Fly   880 MLWVNLIMDTLASLALATEFPTPDLLLRKPYGR-----TKPLISRT-----------------MM 922
            :|.::||.|...:::||.|.|..|::|:.|..:     ||.||:.|                 :.
 Worm   835 ILSIDLISDIPPAVSLAYEGPEADIMLQPPRKKDTHLVTKGLITYTYLFMSIFISIGCVCAYLLS 899

  Fly   923 KNILGQALYQLIIIFGLLF---------VGDVILDIESGRGQELNAGPTQHFTII----FNTFVM 974
            ..|.|...::|.......|         ...|||:.|........|....|.:::    |:.::.
 Worm   900 YYINGIGPWELAFTASTYFKHGAANFTTAKGVILNEEQQMYMANQAAAAFHISLVLGQAFHLWMC 964

  Fly   975 MTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAFSTKALTLDQWLWCIF 1039
            :|....|.|   ||..|::...........|.|||.:..|      |..|.::......||..|.
 Worm   965 LTRRVSIFA---HGLGNIVAIFAVIIDLLLICIFTFVPGV------KYIFGSQPPPWQCWLVPIV 1020

  Fly  1040 FGIGTLVWGQL----ITSVPTRKLPKILSW 1065
            .|:...::.:|    |...|..|..::..|
 Worm  1021 VGVWIWIFNELRKLGIRKYPKNKFVRLTKW 1050

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	P-type_ATPase_Ca_PMCA-like	62..921	CDD:319776	253/961 (26%)
		Cation_ATPase_C	873..1051	CDD:376368	48/216 (22%)
		ATP_Ca_trans_C	1096..1141	CDD:463575
catp-2	NP_504328.1	MgtA	65..1041	CDD:440242	288/1123 (26%)