DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PMCA and catp-3

DIOPT Version :9

Sequence 1:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster
Sequence 2:	NP_505083.1	Gene:	catp-3 / 179189	WormBaseID:	WBGene00015660	Length:	1054	Species:	Caenorhabditis elegans

Alignment Length:	1217	Identity:	308/1217 - (25%)
Similarity:	492/1217 - (40%)	Gaps:	337/1217 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SLKQLRELMEHRG---REGVMK------IAENGGIHELCKKLYTS------PNEGLSGSKADEEH 63
            ||:|.||..:...   :|...|      :.....|.:|.::.:.|      |.:....:|.:...
Worm    10 SLRQRREAADSENSSFKEATHKDLSSSFVEHQMHIAQLSERFFHSKIDIVEPKKSKGLTKQEAAQ 74

  Fly    64 RRETFGSNVIPPKPPKT----------FLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAP 118
            :.:|.|.|.:  .||||          |..|:|       :::...|||..| ...|.|.|.
Worm    75 KLKTDGKNAL--SPPKTISNMELFVRQFKNLLW-------VLMFGAAALCFL-TYIYDPTDA--- 126

  Fly   119 VLQEEEEHHGWIEGLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISV 183
                    .....|:.|:..|.::.:|:.|.:.......|..|..:  .....|||.|:...::.
Worm   127 --------LNLYVGIFIVAIVFIMCVVSFFEEKKGVEVVRAFQTLM--PTSCQVIRDGKEILLNP 181

  Fly   184 GDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVK---KGPDVDPMV-------LS 238
            .:::|||:..|:.|..:|||..:|...|..::.||:|||::.::   |..|....:       .:
Worm   182 EELVVGDVVVVRSGCKVPADMRIIACTDFFLETSSITGEAEPLEFHSKTADAKTSIFESYNIAFN 246

  Fly   239 GTHVMEGSGKMVVTAVGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQ 303
            |:..::|.|            .|||..                             ||||
Worm   247 GSFCVDGEG------------YGIIIR-----------------------------TGEN----- 265

  Fly   304 IKGSQAPSQRETVTSEITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTI 368
                       ||..:|                .:...|.|.:|...:.::.:. :|.      |
Worm   266 -----------TVIGQI----------------ASLTLGQKDKKCKFETEIERF-VQF------I 296

  Fly   369 AVLTVIILIIQFCIKTFVIDEKPWKNTYANNLVKHLIIGVTVLVVA-VPEGLPLAVTLSLAYSVK 432
            .|:.:.:..:.|.|...|        ...|::::..:.|..::::| ||:|||..||..|....:
Worm   297 TVMAITMATVIFTIGLLV--------NGGNDVIRLFVTGFLMVIIANVPQGLPTTVTTELTIIAR 353

  Fly   433 KMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVV-----QSYICEKLCKVLPTLSDIPQ 492
            :|.|.|..::.|:..:::|..|.|.||||||||.|.|||.     .||...:           |:
Worm   354 RMAKKNVFLKKLEKIDSVGATTLIASDKTGTLTKNCMTVTDLWYNNSYNSAR-----------PE 407

  Fly   493 HVG--------NLI-TMG---------ISV----NSA-----YTSNIMAGHNPGDLPIQV----- 525
            :.|        |.| |:|         :||    |.|     .|:.:.......:|.:.|
Worm   408 NQGRTTKKRNLNAINTIGWYDAPLKDILSVICVCNKARIENNLTTKVRPPRVDSELDLTVYKSQP 472

  Fly   526 -------GNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVY--TFNSVRK---SMGTV------ 572
                   ||.:|.|||.:..|: :....:|     |.|..|:  .||||||   .:.|.
Worm   473 VKEMLISGNPSEVALLRYASGM-LDAMEVR-----DSFHVVFEVPFNSVRKYHLILATTEATWAE 531

  Fly   573 ---IPRPNGG--YRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTI 632
               ..:.|..  :.|..|||.::::|.|:.|......:|...:.|.:  ..|..|....:|.|.|
Worm   532 IDDKKKVNADVEFILMIKGAPDVLIKSCSTINIDGVPMELNGKRMDD--FNEAYETFGDEGCRVI 594

  Fly   633 SVAYRDF-VPGKAAI----NEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQR 692
            ..|.:.| .|..:..    |.:.:|   |||          .|.:..|.||.|.:.|.||:.|:.
Worm   595 GFACKKFRAPATSTFSIKSNTIPMD---NWD----------FLGMSAIMDPPRDDTPRAIKACKE 646

  Fly   693 AGITVRMVTGDNINTARSIASKCGILRPNDDFLILEGKEFNRR-IRDSN--------GDIQQHLI 748
            |||.|.|||||:.:||.:||.:.|::...:    :...:.||: ||.:|        |.....|.
Worm   647 AGIKVYMVTGDHKSTATAIARQIGMIDTEE----VTNLDHNRQVIRRTNSQDWAVITGPELPGLS 707

  Fly   749 DKVWPKLR-----VLARSSPTDKYTLVKGIIDSTVSENR-EVVAVTGDGTNDGPALKKADVGFAM 807
            :|.|..|.     |.||::|..|..:|      |.|:.| |.|.|||||.||.|||||||||.||
Worm   708 EKQWDALLEHRYIVFARTTPEHKLMIV------TESQKRGECVTVTGDGVNDAPALKKADVGVAM 766

  Fly   808 GIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLT---VNVVAVIVAFIGACA 869
            |:||:||||:|:||||.||||||||..:..||.::|::.|.:.:.:|   ..:|.|::.|.....
Worm   767 GLAGSDVAKQAADIILLDDNFSSIVAGIEEGRLLFDNLRKTIAYTMTHMWPELVPVMLNFFFGFP 831

  Fly   870 VQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLI 934
            :..:|   ||:|.::||.|...:::||.|.|..|::|:.|..|...|:::       |...|..:
Worm   832 LGLTP---VQILSIDLITDIPPAVSLAYEGPEADIMLQPPRKRETHLVTK-------GLITYTYL 886

  Fly   935 IIFGLLFVGDVILDIESG--RG---QELNAGPTQHFTIIFNTFVMMTLFNEI--NARK------- 985
            .:...:.||.|:..:.|.  .|   .||......||.:..:.|   |.:|.:  ||.:
Worm   887 FMSIFISVGGVVAYLLSYYLNGIYPSELAFSSNDHFKVGASNF---TTYNGVVLNAEQQVFMAAQ 948

  Fly   986 ----------------------------IHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKM 1022
                                        :||..|::..|........|.:||.:..|   ||
Worm   949 AAAAFHIAVVVGQAWHLWMCLTRRVSIFVHGMANIVAILAVIIDLLLICLFTFVPGV---QY--- 1007

  Fly  1023 AFSTKALTLDQWLWCIFFGIGTLVWGQL----ITSVPTRKLPKILSW 1065
            .|.::....:.||..:..||...::.:|    |.:.|..||.:::.|
Worm  1008 VFGSQPPPWECWLVPVIVGIWIWIFNELRKFGIRNYPKNKLVRLVKW 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	305/1207 (25%)
		Cation_ATPase_N	36..104	CDD:279080	18/83 (22%)
		E1-E2_ATPase	172..448	CDD:278548	58/286 (20%)
		Cation_ATPase	505..598	CDD:289987	30/125 (24%)
		HAD_like	676..807	CDD:119389	58/145 (40%)
		Cation_ATPase_C	873..1051	CDD:279079	48/223 (22%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
catp-3	NP_505083.1	HAD_like	66..1044	CDD:389748	293/1149 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156298
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940