DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PMCA and mca-1

DIOPT Version :9

Sequence 1:NP_001014689.3 Gene:PMCA / 43787 FlyBaseID:FBgn0259214 Length:1255 Species:Drosophila melanogaster
Sequence 2:NP_501709.2 Gene:mca-1 / 177795 WormBaseID:WBGene00003151 Length:1252 Species:Caenorhabditis elegans


Alignment Length:1290 Identity:654/1290 - (50%)
Similarity:829/1290 - (64%) Gaps:147/1290 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 QYGISLKQLRELMEHRGREGVMKIA-ENGGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVI 73
            ::|.||..||.|||.||.|.::::: |:.|:..|||||.|....||:|.:||.:.||..:|:|.|
 Worm    39 EFGCSLGDLRGLMEARGAEAIVRLSTEHEGVEGLCKKLKTDSLVGLNGEQADLDRRRHVYGANTI 103

  Fly    74 PPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKP--ADEDA------------------- 117
            ||...|.|:.||.:|.:|.||:||.::..::|.||||:|  |.|||                   
 Worm   104 PPAKSKGFVRLVLDACKDPTLVILVLSGFINLALSFYEPTSAAEDATQHLVNATTAAILANGTFM 168

  Fly   118 PVLQEEEEHHG--WIEGLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQ 180
            ...:...|.||  ||||:|||:.|||||:|||.||||||||||.||.:||...||||||.||...
 Worm   169 STTEAPSEGHGTAWIEGVAILLCVIVVVLVTAVNDYSKERQFRSLQEKIETGQKFSVIRNGEAID 233

  Fly   181 ISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEG 245
            :.|.|::|||||:|||||||||||.||||||||:|||||||||||:||..:.||::||||:.|||
 Worm   234 VPVSDLVVGDIARVKYGDLLPADGFLIQSNDLKIDESSLTGESDHIKKSIESDPVLLSGTYAMEG 298

  Fly   246 SGKMVVTAVGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAP 310
            ||||::||||||||.|||.|||||.                     |...|::|..|        
 Worm   299 SGKMLITAVGVNSQTGIIMTLLGAG---------------------KAGIGDDDSTS-------- 334

  Fly   311 SQRETVTSEITKSESEGNHLPQSSSSGAAETGHKKE-----KSVLQAKLTKLAIQIGYAGSTIAV 370
                |.:|..:.|.|.|     |||:|::::....:     ||||||||:|||:||.|.|:|||:
 Worm   335 ----TSSSSSSSSSSSG-----SSSNGSSDSSKSGDDDLTAKSVLQAKLSKLALQIIYCGTTIAI 390

  Fly   371 LTVIILIIQFCIKTFVIDEKPWKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMM 435
            :.:|:|:.:||:..:|.::..:........||..||.||:||:::|||||||:.|:|.|||:|||
 Worm   391 IALIVLVTRFCLDHYVFEKNEFSLVDIQMFVKFFIIAVTILVISIPEGLPLAIALALTYSVRKMM 455

  Fly   436 KDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEK---LCKVLPTLSDIPQHVGNL 497
            .||||||||||||||||||:|||||||||||||||||||||...   ..:..|..:::|...|.:
 Worm   456 HDNNLVRHLDACETMGNATSICSDKTGTLTTNRMTVVQSYINGNHYTSQEAQPHGANLPGSTGPI 520

  Fly   498 ITMGISVNSAYTSNIMAGHNPGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTF 562
            :...||||.||.|.|:.....|:...|:||||||.|||||..||..|.:||.:..|...|:||||
 Worm   521 LMEAISVNCAYNSMIVEPTKAGEQIQQLGNKTECGLLGFVNRLGGDYAAIRKKFPEHDLTKVYTF 585

  Fly   563 NSVRKSMGTVIP-RPNG---GYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEP 623
            ||.||.|.||:| ..||   |||:|.||||||::.:|.::.|.:|...:.|.|..:.:...:|..
 Worm   586 NSSRKCMMTVVPYAENGQNIGYRVYCKGASEIVLGRCTYLIGSDGKPHQLTGDRLKEITSTIIHE 650

  Fly   624 MACDGLRTISVAYRDFV-PGKAAINEVHI----DGEPNWDDEENIMTNLTCLCVVGIEDPVRPEV 683
            ||..|||||.|||:..: .|...:.:..|    |.:.:||||:.:..|.|.:.:.||:|||||||
 Worm   651 MANSGLRTICVAYKTIIKKGTRDVEKTEIEFAEDSDIDWDDEDAMYQNFTGIAICGIQDPVRPEV 715

  Fly   684 PDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLI 748
            |.||.||::|||||||||||||.|||:||..|.||.|.:|||.|||||||.||||.||.:.|..:
 Worm   716 PVAISKCKKAGITVRMVTGDNIMTARAIAMSCKILEPGEDFLALEGKEFNERIRDENGKVSQAKL 780

  Fly   749 DKVWPKLRVLARSSPTDKYTLVKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTD 813
            |::||:||||||:.|.||||||||||||..:..||:|||||||||||||||||||||||||||||
 Worm   781 DEIWPRLRVLARAQPADKYTLVKGIIDSKATPQREIVAVTGDGTNDGPALKKADVGFAMGIAGTD 845

  Fly   814 VAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAV 878
            |||||||||||||||:||||||||||||||||:|||||||||||||||.||:||..|.|||||||
 Worm   846 VAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVITAFVGAVTVSDSPLKAV 910

  Fly   879 QMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVG 943
            .|||:|||||||||||||||.||.:||.||||||.|.||||||:||||..|||||||||.:.|.|
 Worm   911 HMLWINLIMDTLASLALATEQPTDELLERKPYGRKKSLISRTMVKNILCHALYQLIIIFVIFFYG 975

  Fly   944 DVILDIESGRGQELNAGPTQHFTIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIF 1008
            |.|..|::|....|.|.|:||||::||.|||||:||||||||:||:|||.:||.:|.:|..||:.
 Worm   976 DTIFGIKTGLYAPLFAPPSQHFTLVFNAFVMMTVFNEINARKVHGERNVFKGLASNRVFCVIWVT 1040

  Fly  1009 TMISQVLIIQYGKMAFSTKALTLDQWLWCIFFGIGTLVWGQLITSVPTRKLPKILSWGRGHPEEY 1073
            |.|:|::|:|:|...|||..|||.||:.|:..|..||:|||::.::|::||||....|:|..:. 
 Worm  1041 TFIAQIIIVQFGGAWFSTAPLTLQQWIVCLVLGFSTLIWGQIVATIPSKKLPKAWKVGKGEVQP- 1104

  Fly  1074 TDGMNLGEERFDSIDSDKKPRA----------GQILWIRGLTRLQTQLRVIRAFRSTLEDLNERR 1128
               .||      .|:.|...||          |:.||:||:..:...|||:|||       ...:
 Worm  1105 ---ANL------HINGDYNVRARSRAVTLRRSGKSLWVRGMFIIGNHLRVLRAF-------GMEK 1153

  Fly  1129 SMHSLHSLRSPRTGIPVAVGGGHPLYNFNLLNPNYIK--HQQQQEPKLPPQTQLNVSSGMMSPDI 1191
            |..:.....:|......|          .....:|.|  ||:.||.|...:|..:|.|.      
 Worm  1154 SEKAAFGRTAPAMTAEAA----------ERWRASYRKYRHQKHQEKKATAETAESVKSA------ 1202

  Fly  1192 SYIDEDPQQQQRTLHNGLTSQRSSMPSNVPSSNQSFSKIAQTLQQKIRGNIETKH 1246
               |...:|:::                    .::|.:|.|..:.|.......||
 Worm  1203 ---DWAKEQKEK--------------------KKTFKQIKQVARGKSLDKDSKKH 1234

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PMCANP_001014689.3 ATPase-IIB_Ca 1..1057 CDD:273668 610/1087 (56%)
Cation_ATPase_N 36..104 CDD:279080 29/67 (43%)
E1-E2_ATPase 172..448 CDD:278548 142/280 (51%)
Cation_ATPase 505..598 CDD:289987 50/96 (52%)
HAD_like 676..807 CDD:119389 96/130 (74%)
Cation_ATPase_C 873..1051 CDD:279079 114/177 (64%)
ATP_Ca_trans_C 1096..1142 CDD:289209 13/45 (29%)
mca-1NP_501709.2 ATPase-IIB_Ca 46..1087 CDD:273668 606/1078 (56%)
Cation_ATPase_N 66..133 CDD:279080 29/66 (44%)
E1-E2_ATPase 225..468 CDD:278548 142/280 (51%)
Cation_ATPase 532..624 CDD:289987 47/91 (52%)
Cation_ATPase_C 905..1083 CDD:279079 114/177 (64%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 156 1.000 Domainoid score I2556
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53587
OrthoDB 1 1.010 - - D115892at2759
OrthoFinder 1 1.000 - - FOG0000362
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100143
Panther 1 1.100 - - O PTHR24093
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X220
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
98.930

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