DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PMCA and mca-2

DIOPT Version :9

Sequence 1:NP_001014689.3 Gene:PMCA / 43787 FlyBaseID:FBgn0259214 Length:1255 Species:Drosophila melanogaster
Sequence 2:NP_500161.1 Gene:mca-2 / 177004 WormBaseID:WBGene00019875 Length:1158 Species:Caenorhabditis elegans


Alignment Length:1131 Identity:671/1131 - (59%)
Similarity:814/1131 - (71%) Gaps:55/1131 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 YGISLKQLRELMEHRGREGVMKI-AENGGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVIP 74
            |..|:.:|:.|||.||.|.:.|: :...|:..||:||.|.|..||.....:.||||..||.|.||
 Worm     7 YDCSISELKLLMELRGAEALEKVNSTYNGVEGLCRKLKTDPINGLPNDTKELEHRRTAFGKNEIP 71

  Fly    75 PKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVLQEEEEHHGWIEGLAILISV 139
            |.|.|:|..|.||||||:||:||.||||||||||||||..|.|.....|.| .|||||:|||::|
 Worm    72 PAPSKSFFRLAWEALQDITLVILLVAALVSLGLSFYKPPAEHASNDSSESE-AGWIEGVAILVAV 135

  Fly   140 IVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADG 204
            :|||:|||.||::||:||||||::||.|||||||||||...|.|.:::|||||:|||||||||||
 Worm   136 LVVVLVTALNDWTKEKQFRGLQSKIETEHKFSVIRGGEPLDIVVNELVVGDIARVKYGDLLPADG 200

  Fly   205 CLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGA 269
            .||||||||:||||||||||.::|..:.||::|||||.|||||:.:|||||:|||.|||.:||||
 Worm   201 LLIQSNDLKIDESSLTGESDLIRKSEEFDPVLLSGTHAMEGSGRFLVTAVGLNSQTGIIMSLLGA 265

  Fly   270 AVDEQEAEIKKMKKEAKRANKQKNLTGEND----GRSQIKGSQAPSQRETVTSEITKSESEGNHL 330
            |         |.||:.|: .:...||..|.    |....|.::.|                   :
 Worm   266 A---------KEKKDDKK-EEPTTLTNGNHMNGLGNGVDKAAELP-------------------V 301

  Fly   331 PQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEKPWKNT 395
            |:....|      :..|||||.||:.||:||||.||.:|..||:||||:.||..:.|:.|.::.:
 Worm   302 PEEEEVG------RMSKSVLQTKLSNLALQIGYIGSIVAAATVLILIIRHCISKYAIEGKSFEAS 360

  Fly   396 YANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDK 460
            ..::.|..:||||||||:|||||||||:||:|.||||||||||||||||||||||||||:|||||
 Worm   361 DISHFVNFIIIGVTVLVIAVPEGLPLAITLALTYSVKKMMKDNNLVRHLDACETMGNATSICSDK 425

  Fly   461 TGTLTTNRMTVVQSYICEKLCK-VLPTLSDIPQHVGNLITMGISVNSAYTSNIMAGHNPGDLPIQ 524
            ||||||||||.||.||..:..| ..|....:.....:::..||.:||.|.|.::...|||:...|
 Worm   426 TGTLTTNRMTCVQQYINSEFYKGNAPKYEQMDPSTRDILFNGIVINSGYNSTVVTPKNPGEQRGQ 490

  Fly   525 VGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSMGTVIPRPNGGYRLYTKGASE 589
            :||||||:||||:...|..|:.:|.:..|:|..:||||||.||||.|||...:..||:|.|||||
 Worm   491 IGNKTECSLLGFIMDSGRSYEDLRRQFPEEKLYKVYTFNSSRKSMMTVIELGDKKYRIYAKGASE 555

  Fly   590 IIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISVAYRDFVP--GKAAINEVHID 652
            ||:.:|.:|:|..|.:|:|.......:.:.||||||.||||||.:|::|.||  .|....|...|
 Worm   556 IILTRCNYIFGKSGKIEQFGPKEAAVMTKNVIEPMASDGLRTIGLAFKDLVPAGSKKYEYEEEYD 620

  Fly   653 GEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGI 717
            ||.:|:|||.|....|.:.|:||:||||||||.||.|||:||||||||||||||||||||::|||
 Worm   621 GEIDWEDEEKIREGQTVIAVMGIQDPVRPEVPAAIAKCQKAGITVRMVTGDNINTARSIATQCGI 685

  Fly   718 LRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDSTVSENR 782
            ::|..|||.|||||||.||||::|.:.|...|.:|||||||||:.|:|||.||||||:|||::||
 Worm   686 MQPGGDFLALEGKEFNARIRDADGKVNQQKFDAIWPKLRVLARAQPSDKYVLVKGIIESTVTKNR 750

  Fly   783 EVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAK 847
            ||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||
 Worm   751 EVVAVTGDGTNDAPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAK 815

  Fly   848 FLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGR 912
            |||||||||||||.:|||||||:.|||||||||||||||||||||||||||.||.|||.||||||
 Worm   816 FLQFQLTVNVVAVTIAFIGACAISDSPLKAVQMLWVNLIMDTLASLALATEMPTEDLLNRKPYGR 880

  Fly   913 TKPLISRTMMKNILGQALYQLIIIFGLLFVGD-VILDIESGRGQELNAGPTQHFTIIFNTFVMMT 976
            ||.||||||:|||:|.|:|||.|:|.::|.|| :|.:..|||..||.:.|:.|||||||.||:||
 Worm   881 TKSLISRTMVKNIVGHAVYQLAILFAIMFWGDKLIPNTPSGRNAELGSPPSAHFTIIFNAFVLMT 945

  Fly   977 LFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAFSTKALTLDQWLWCIFFG 1041
            |.||||||||||:|||.:|:.|||||..|||.|:||.:||:|:|...|||..|.|.||:.||..|
 Worm   946 LVNEINARKIHGERNVFKGIFTNPIFCVIWITTLISHILIVQFGGQWFSTAPLDLTQWIICICCG 1010

  Fly  1042 IGTLVWGQLITSVPTRKLPKILSWGRGHPEEYTDGMNLGEERFDSIDSD---------KKPRAGQ 1097
            :|.|.|||:|..:|...|||...:|:|..:. |..|..||....|..|.         ...||||
 Worm  1011 VGELFWGQIINCIPAS
ILPKSFRFGKGDVQP-TSIMLSGEYDMPSTASTLPMKDGAAADHQRAGQ 1074

  Fly  1098 ILWIRGLTRLQTQLRVIRAFRSTLED 1123
            .||:.||||||||:||::||:|..:|
 Worm  1075 SLWLLGLTRLQTQIRVVKAFQSVNDD 1100

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PMCANP_001014689.3 ATPase-IIB_Ca 1..1057 CDD:273668 640/1054 (61%)
Cation_ATPase_N 36..104 CDD:279080 37/67 (55%)
E1-E2_ATPase 172..448 CDD:278548 148/279 (53%)
Cation_ATPase 505..598 CDD:289987 47/92 (51%)
HAD_like 676..807 CDD:119389 100/130 (77%)
Cation_ATPase_C 873..1051 CDD:279079 121/178 (68%)
ATP_Ca_trans_C 1096..1142 CDD:289209 18/28 (64%)
mca-2NP_500161.1 ATPase-IIB_Ca 5..1026 CDD:273668 640/1054 (61%)
Cation_ATPase_N 35..101 CDD:279080 37/65 (57%)
E1-E2_ATPase 168..413 CDD:278548 148/279 (53%)
Cation_ATPase 475..564 CDD:289987 44/88 (50%)
HAD <648..767 CDD:289480 89/118 (75%)
Cation_ATPase_C 841..1020 CDD:279079 121/178 (68%)
ATP_Ca_trans_C 1073..>1096 CDD:289209 16/22 (73%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 218 1.000 Domainoid score I1526
eggNOG 1 0.900 - - E2759_KOG0204
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H123775
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53587
OrthoDB 1 1.010 - - D115892at2759
OrthoFinder 1 1.000 - - FOG0000362
OrthoInspector 1 1.000 - - otm14259
orthoMCL 1 0.900 - - OOG6_100143
Panther 1 1.100 - - O PTHR24093
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R99
SonicParanoid 1 1.000 - - X220
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.860

Return to query results.
Submit another query.