Protein Alignment PMCA and mca-2

DIOPT Version :10

• Sequence 1: NP_001014689.3
• Gene: PMCA / 43787
• FlyBaseID: FBgn0259214
• Length: 1255
• Species: Drosophila melanogaster
• Sequence 2: NP_500161.1
• Gene: mca-2 / 177004
• WormBaseID: WBGene00019875
• Length: 1158
• Species: Caenorhabditis elegans
• Alignment Length: 1131
• Identity: 671/1131 - (59%)
• Similarity: 814/1131 - (71%)
• Gaps: 55/1131 - (4%)

  Fly    11 YGISLKQLRELMEHRGREGVMKI-AENGGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVIP 74
            |..|:.:|:.|||.||.|.:.|: :...|:..||:||.|.|..||.....:.||||..||.|.||
 Worm     7 YDCSISELKLLMELRGAEALEKVNSTYNGVEGLCRKLKTDPINGLPNDTKELEHRRTAFGKNEIP 71

  Fly    75 PKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVLQEEEEHHGWIEGLAILISV 139
            |.|.|:|..|.||||||:||:||.||||||||||||||..|.|.....|.| .|||||:|||::|
 Worm    72 PAPSKSFFRLAWEALQDITLVILLVAALVSLGLSFYKPPAEHASNDSSESE-AGWIEGVAILVAV 135

  Fly   140 IVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADG 204
            :|||:|||.||::||:||||||::||.|||||||||||...|.|.:::|||||:|||||||||||
 Worm   136 LVVVLVTALNDWTKEKQFRGLQSKIETEHKFSVIRGGEPLDIVVNELVVGDIARVKYGDLLPADG 200

  Fly   205 CLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGA 269
            .||||||||:||||||||||.::|..:.||::|||||.|||||:.:|||||:|||.|||.:||||
 Worm   201 LLIQSNDLKIDESSLTGESDLIRKSEEFDPVLLSGTHAMEGSGRFLVTAVGLNSQTGIIMSLLGA 265

  Fly   270 AVDEQEAEIKKMKKEAKRANKQKNLTGEND----GRSQIKGSQAPSQRETVTSEITKSESEGNHL 330
            |         |.||:.|: .:...||..|.    |....|.::.|                   :
 Worm   266 A---------KEKKDDKK-EEPTTLTNGNHMNGLGNGVDKAAELP-------------------V 301

  Fly   331 PQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEKPWKNT 395
            |:....|      :..|||||.||:.||:||||.||.:|..||:||||:.||..:.|:.|.::.:
 Worm   302 PEEEEVG------RMSKSVLQTKLSNLALQIGYIGSIVAAATVLILIIRHCISKYAIEGKSFEAS 360

  Fly   396 YANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDK 460
            ..::.|..:||||||||:|||||||||:||:|.||||||||||||||||||||||||||:|||||
 Worm   361 DISHFVNFIIIGVTVLVIAVPEGLPLAITLALTYSVKKMMKDNNLVRHLDACETMGNATSICSDK 425

  Fly   461 TGTLTTNRMTVVQSYICEKLCK-VLPTLSDIPQHVGNLITMGISVNSAYTSNIMAGHNPGDLPIQ 524
            ||||||||||.||.||..:..| ..|....:.....:::..||.:||.|.|.::...|||:...|
 Worm   426 TGTLTTNRMTCVQQYINSEFYKGNAPKYEQMDPSTRDILFNGIVINSGYNSTVVTPKNPGEQRGQ 490

  Fly   525 VGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSMGTVIPRPNGGYRLYTKGASE 589
            :||||||:||||:...|..|:.:|.:..|:|..:||||||.||||.|||...:..||:|.|||||
 Worm   491 IGNKTECSLLGFIMDSGRSYEDLRRQFPEEKLYKVYTFNSSRKSMMTVIELGDKKYRIYAKGASE 555

  Fly   590 IIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISVAYRDFVP--GKAAINEVHID 652
            ||:.:|.:|:|..|.:|:|.......:.:.||||||.||||||.:|::|.||  .|....|...|
 Worm   556 IILTRCNYIFGKSGKIEQFGPKEAAVMTKNVIEPMASDGLRTIGLAFKDLVPAGSKKYEYEEEYD 620

  Fly   653 GEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGI 717
            ||.:|:|||.|....|.:.|:||:||||||||.||.|||:||||||||||||||||||||::|||
 Worm   621 GEIDWEDEEKIREGQTVIAVMGIQDPVRPEVPAAIAKCQKAGITVRMVTGDNINTARSIATQCGI 685

  Fly   718 LRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDSTVSENR 782
            ::|..|||.|||||||.||||::|.:.|...|.:|||||||||:.|:|||.||||||:|||::||
 Worm   686 MQPGGDFLALEGKEFNARIRDADGKVNQQKFDAIWPKLRVLARAQPSDKYVLVKGIIESTVTKNR 750

  Fly   783 EVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAK 847
            ||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||
 Worm   751 EVVAVTGDGTNDAPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAK 815

  Fly   848 FLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGR 912
            |||||||||||||.:|||||||:.|||||||||||||||||||||||||||.||.|||.||||||
 Worm   816 FLQFQLTVNVVAVTIAFIGACAISDSPLKAVQMLWVNLIMDTLASLALATEMPTEDLLNRKPYGR 880

  Fly   913 TKPLISRTMMKNILGQALYQLIIIFGLLFVGD-VILDIESGRGQELNAGPTQHFTIIFNTFVMMT 976
            ||.||||||:|||:|.|:|||.|:|.::|.|| :|.:..|||..||.:.|:.|||||||.||:||
 Worm   881 TKSLISRTMVKNIVGHAVYQLAILFAIMFWGDKLIPNTPSGRNAELGSPPSAHFTIIFNAFVLMT 945

  Fly   977 LFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAFSTKALTLDQWLWCIFFG 1041
            |.||||||||||:|||.:|:.|||||..|||.|:||.:||:|:|...|||..|.|.||:.||..|
 Worm   946 LVNEINARKIHGERNVFKGIFTNPIFCVIWITTLISHILIVQFGGQWFSTAPLDLTQWIICICCG 1010

  Fly  1042 IGTLVWGQLITSVPTRKLPKILSWGRGHPEEYTDGMNLGEERFDSIDSD---------KKPRAGQ 1097
            :|.|.|||:|..:|...|||...:|:|..:. |..|..||....|..|.         ...||||
 Worm  1011 VGELFWGQIINCIPASILPKSFRFGKGDVQP-TSIMLSGEYDMPSTASTLPMKDGAAADHQRAGQ 1074

  Fly  1098 ILWIRGLTRLQTQLRVIRAFRSTLED 1123
            .||:.||||||||:||::||:|..:|
 Worm  1075 SLWLLGLTRLQTQIRVVKAFQSVNDD 1100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	P-type_ATPase_Ca_PMCA-like	62..921	CDD:319776	541/865 (63%)
		Cation_ATPase_C	873..1051	CDD:376368	121/178 (68%)
		ATP_Ca_trans_C	1096..1141	CDD:463575	18/28 (64%)
mca-2	NP_500161.1	P-type_ATPase_Ca_PMCA-like	58..889	CDD:319776	541/866 (62%)
		Cation_ATPase_C	841..1020	CDD:376368	121/178 (68%)
		ATP_Ca_trans_C	1073..>1096	CDD:463575	16/22 (73%)