Protein Alignment PMCA and cua-1

DIOPT Version :10

• Sequence 1: NP_001014689.3
• Gene: PMCA / 43787
• FlyBaseID: FBgn0259214
• Length: 1255
• Species: Drosophila melanogaster
• Sequence 2: NP_001255202.1
• Gene: cua-1 / 176770
• WormBaseID: WBGene00000834
• Length: 1238
• Species: Caenorhabditis elegans
• Alignment Length: 847
• Identity: 179/847 - (21%)
• Similarity: 296/847 - (34%)
• Gaps: 278/847 - (32%)

  Fly   133 LAILISVIVVVIVTAFNDYSKERQF--------------RGLQNRIEGE-----HKFSVIRGGEV 178
            :|...|::|:::...|...|....|              |.|:::.:|:     .|...::..|.
 Worm   504 IAYTYSIVVLLLAIIFKWPSSPMTFFDVPPMLIVFIALGRMLEHKAKGKTSEALSKLMSLQAKEA 568

  Fly   179 CQISVGD--------------ILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKG 229
            ..:::..              :...|:.:|..|..:|.||.::.... .||||.:||||..|.|.
 Worm   569 TLVTMDSEGRLTSEKGINIELVQRNDLIKVVPGAKVPVDGVVVDGKS-SVDESFITGESMPVVKK 632

  Fly   230 PDVDPMVLSGTHVMEGS----GKMVVTAVGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANK 290
            |        |:.|:.||    |.::|.|..|.:             |...::|.::.:||:.
 Worm   633 P--------GSTVIGGSVNQKGVLIVKATHVGN-------------DSTLSQIVRLVEEAQT--- 673

  Fly   291 QKNLTGENDGRSQIKGSQAPSQRETVTSEITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLT 355
                            ::||.|
 Worm   674 ----------------NRAPIQ------------------------------------------- 679

  Fly   356 KLAIQI-GYAGSTIAVLTVIILIIQFCIKTFVIDEKPWKNTYAN-NLVKHLII----------GV 408
            :||.:| ||....:.||::..|.:...|:         .|:..| ||...|..          .:
 Worm   680 QLADKIAGYFVPFVIVLSLFTLGVWIYIE---------YNSARNANLPPGLRFEEALKIAFEAAI 735

  Fly   409 TVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQ 473
            |||.:|.|..|.||...::.........:..|::..:..|::...|.|..|||||:|..|..|||
 Worm   736 TVLAIACPCSLGLATPTAVMVGTGVGAANGILIKGGEPLESVHKVTTIVFDKTGTITEGRPRVVQ 800

  Fly   474 -------SYICEKLCKVL----PTLSDIPQHVGNLITMGISVNSAYTSNIM---AGHNPGDLPIQ 524
                   |.:..||...|    ..||:.|  :||.:       :|:...::   ...|.....:.
 Worm   801 IASFVNPSTMSLKLITFLSGATEALSEHP--IGNAV-------AAFAKQLLNEPTWPNTSRFHVS 856

  Fly   525 VGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSMGTV-IPRPNGGYRLYTKGAS 588
            .|:...|           :..|||.           :|:|:..|..|. |||...|..:...|..
 Worm   857 AGHGVTC-----------RIDSIRQ-----------SFSSLALSGSTCEIPRLPDGQTITIPGTE 899

  Fly   589 ----EIIMKKCAFIYGHEGTLEKFTRDMQER---LIREVIEPMACDGLRTISVAYRDFVPGKAAI 646
                ::..|:.:........:...|..|.||   .:.||::       .|:|...|     |..|
 Worm   900 VNLLQVSSKEVSQPNPDTANIVIGTERMMERHGIPVSEVVK-------MTLSEEQR-----KGHI 952

  Fly   647 NEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSI 711
            :.:             ...|...:.|:.|.|.|:.|...||...:..|:.|.::||||..||.|.
 Worm   953 SVI-------------CAINAEVVAVISIADQVKKEASLAIYTLREMGLRVVLLTGDNSKTAEST 1004

  Fly   712 ASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDS 776
            |.:.||    |:                                 |.|...|..|...:|
 Worm  1005 AKQVGI----DE---------------------------------VFAEVLPNQKQQKIK----- 1027

  Fly   777 TVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNV 841
            .:...:..||:.|||.||.|||.:|:||.|:. ||:|||.|::.|:|..::...:|.|:...:..
 Worm  1028 QLKGYKNKVAMVGDGVNDSPALAEANVGIAIA-AGSDVAIESAGIVLVRNDLVDVVGAIKLSKMT 1091

  Fly   842 YDSIAKFLQFQLTVNVVAVIVA-------------FIGACAVQDSPLKAV--QMLWVNLIMDTLA 891
            ...|.....|.:..|.:.:.:|             ::.|.|:..|.:..|  .:|..|....|:|
 Worm  1092 TRRIRLNFLFAIIYNAIGIPIAAGVFRPFGFMLQPWMAAAAMALSSVSVVSSSLLLKNFRKPTIA 1156

  Fly   892 SL 893
            :|
 Worm  1157 NL 1158

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	P-type_ATPase_Ca_PMCA-like	62..921	CDD:319776	179/847 (21%)
		Cation_ATPase_C	873..1051	CDD:376368	7/23 (30%)
		ATP_Ca_trans_C	1096..1141	CDD:463575
cua-1	NP_001255202.1	HMA	50..113	CDD:238219
		HMA	134..196	CDD:238219
		HMA	253..317	CDD:238219
		CopZ	330..398	CDD:442020
		P-type_ATPase_Cu-like	419..1127	CDD:319783	170/814 (21%)