DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PMCA and sca-1

DIOPT Version :9

Sequence 1:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster
Sequence 2:	NP_499386.1	Gene:	sca-1 / 176512	WormBaseID:	WBGene00004736	Length:	1059	Species:	Caenorhabditis elegans

Alignment Length:	1161	Identity:	305/1161 - (26%)
Similarity:	497/1161 - (42%)	Gaps:	237/1161 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 MKIAENGGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVIPPKPPKTFLTLVWEALQDVTLI 95
            |:.|.....:|:||...|.| |||:..:.  |..|..:|.|.:|.:..|:...|:.|...|:.:.
Worm     1 MEDAHAKDANEVCKFFGTGP-EGLTPQQV--ETLRNKYGENEMPAEEGKSLWELILEQFDDLLVK 62

  Fly    96 ILEVAALVSLGLSFYKPADEDAPVLQEEEEHHGWIEGLAILISVIVVVIVTAFNDYSKERQFRGL 160
            ||.:||::|..|:.:             |||....|.:...:...|::::...|......|.|..
Worm    63 ILLLAAIISFVLALF-------------EEHEDQTEAVTAFVEPFVILLILIANATVGVWQERNA 114

  Fly   161 QNRIEGEHKF-----SVIRGGE--VCQISVGDILVGDIAQVKYGDLLPADGCLIQ--SNDLKVDE 216
            ::.||...::     .|||.|.  :..:...:::.||:.:|..||.:|||..|::  |..:::|:
Worm   115 ESAIEALKEYEPEMAKVIRSGHHGIQMVRAKELVPGDLVEVSVGDKIPADLRLVKIYSTTIRIDQ 179

  Fly   217 SSLTGESDHVKKGPDVDP-----------MVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGAA 270
            |.|||||..|.|..|..|           .:.|||:|..|..:            ||:|.
Worm   180 SILTGESVSVIKHTDSVPDPRAVNQDKKNCLFSGTNVASGKAR------------GIVFG----- 227

  Fly   271 VDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSESEGNHLPQSSS 335
                                    ||                   :|:||.|..:|
Worm   228 ------------------------TG-------------------LTTEIGKIRTE--------- 240

  Fly   336 SGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEKPWKNTYANNL 400
              .|||  :.||:.||.||.:...|:....|.|.|....|.|..|       ::.....::....
Worm   241 --MAET--ENEKTPLQQKLDEFGEQLSKVISVICVAVWAINIGHF-------NDPAHGGSWVKGA 294

  Fly   401 VKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLT 465
            :.:..|.|.:.|.|:|||||..:|..||...::|.|.|.:||.|.:.||:|..:.||||||||||
Worm   295 IYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLT 359

  Fly   466 TNRMTVVQSYICEKLCKVLPTLSDIP------QHVGNLITMGISVNSA--------YTSNIMAGH 516
            ||:|:|.:.:|..:........::..      :.||.:.|.|..:|.|        ..:.|.|..
Worm   360 TNQMSVSKMFIAGQASGDNINFTEFAISGSTYEPVGKVSTNGREINPAAGEFESLTELAMICAMC 424

  Fly   517 NPGDLPI--------QVGNKTECALLGFVQGLGV-----------KYQSIRDEITEDKFTRVYT- 561
            |...:..        :||..||.||:...:.:.|           :...:.:.:.:.|:.:.:|
Worm   425 NDSSVDYNETKKIYEKVGEATETALIVLAEKMNVFGTSKAGLSPKELGGVCNRVIQQKWKKEFTL 489

  Fly   562 -FNSVRKSMGT-VIPRPNG-GYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVI-- 621
             |:..||||.. ..|...| |.:::.|||.|.::.:|..:..: |.....|..|.::::.:.:
Worm   490 EFSRDRKSMSAYCFPASGGSGAKMFVKGAPEGVLGRCTHVRVN-GQKVPLTSAMTQKIVDQCVQY 553

  Fly   622 ----EPMACDGLRTISVAYRDFVPGKAAINEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPE 682
                :.:.|..|.||..        ..:::.::::....:...|.   ::|.:.|||:.||.|.|
Worm   554 GTGRDTLRCLALGTIDT--------PVSVSNMNLEDSTQFVKYEQ---DITFVGVVGMLDPPRTE 607

  Fly   683 VPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHL 747
            |.|:|:.|..|||.|.|:||||.|||.:|..:.|:...|:|   ..||.:..|..|   |:....
Worm   608 VSDSIKACNHAGIRVIMITGDNKNTAEAIGRRIGLFGENED---TTGKAYTGREFD---DLPPEQ 666

  Fly   748 IDKVWPKLRVLARSSPTDKYTLVKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGT 812
            ..:...:.::.||..|:.|    ..|:|...|:. |:.|:||||.||.||||||::|.:|| :||
Worm   667 QSEACRRAKLFARVEPSHK----SKIVDILQSQG-EITAMTGDGVNDAPALKKAEIGISMG-SGT 725

  Fly   813 DVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKA 877
            .|||.||:::|.||||:|||.||..||.:|:::.:|:::.::.||..|:..|:.|.......|..
Worm   726 AVAKSASEMVLADDNFASIVSAVEEGRAIYNNMKQFIRYLISSNVGEVVSIFMVAALGIPEALIP 790

  Fly   878 VQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFG---- 938
            ||:|||||:.|.|.:.||....|..|::.|.|......|||..:....|....|..:...|
Worm   791 VQLLWVNLVTDGLPATALGFNPPDLDIMDRHPRSANDGLISGWLFFRYLAVGTYVGVATVGASMW 855

  Fly   939 --LLF-VGDVI----------LDIESGRGQELNAG------PTQHFTIIFNTFVMMTLFNEINAR 984
              ||: .|..|          .:||.....:|:..      |......:..|..|:...|.::..
Worm   856 WFLLYEEGPQITYYQLTHWMRCEIEPDNFADLDCAVFEDNHPNAMALSVLVTIEMLNAINSLSEN 920

  Fly   985 KIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAFSTKALTLDQWLWCIFFGIGTLVWGQ 1049
                     :.||..|.:..||:...||         ::.|...:.|...:....|.|..|.|.:
Worm   921 ---------QSLLVMPPWKNIWLMAAIS---------LSMSLHFVILYVDIMATIFQITPLNWVE 967

  Fly  1050 LIT----SVPTRKLPKILSWGRGHPEEYTDGMNLGEERFDSIDSDKKPRAGQILWI 1101
            .|.    |:|...|.:||.:   ....|.||      :.:::.:..:.....:.|:
Worm   968 WIAVLKISLPVLLLDEILKF---IARNYIDG------KPETVGAKARSAISLLAWV 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	298/1115 (27%)
		Cation_ATPase_N	36..104	CDD:279080	21/67 (31%)
		E1-E2_ATPase	172..448	CDD:278548	74/290 (26%)
		Cation_ATPase	505..598	CDD:289987	27/123 (22%)
		HAD_like	676..807	CDD:119389	51/130 (39%)
		Cation_ATPase_C	873..1051	CDD:279079	46/200 (23%)
		ATP_Ca_trans_C	1096..1142	CDD:289209	1/6 (17%)
sca-1	NP_499386.1	Cation_ATPase_N	4..71	CDD:279080	22/69 (32%)
		ATPase-IIA1_Ca	52..990	CDD:273452	284/1075 (26%)
		E1-E2_ATPase	95..342	CDD:278548	80/326 (25%)
		Cation_ATPase	423..529	CDD:289987	23/105 (22%)
		HAD	<607..713	CDD:289480	43/116 (37%)
		Cation_ATPase_C	785..988	CDD:279079	52/223 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920