Protein Alignment PMCA and pmr-1

DIOPT Version :9

• Sequence 1: NP_001014689.3
• Gene: PMCA / 43787
• FlyBaseID: FBgn0259214
• Length: 1255
• Species: Drosophila melanogaster
• Sequence 2: NP_001021862.1
• Gene: pmr-1 / 173176
• WormBaseID: WBGene00004063
• Length: 978
• Species: Caenorhabditis elegans
• Alignment Length: 1077
• Identity: 289/1077 - (26%)
• Similarity: 474/1077 - (44%)
• Gaps: 231/1077 - (21%)

  Fly    34 AENGGIHEL--C-KKLYTSPNEGLSGSKADEEHRRETFGSNVIPPKPPKTFLTLVWEALQDVTLI 95
            :|....||:  | .:|.|:..|||  :.|:...||:..|.|.......:.......|..|:..::
 Worm    84 SEQAASHEVVPCTHQLRTNLEEGL--TTAEATRRRQYHGYNEFDVGEEEPIYKKYLEQFQNPLIL 146

  Fly    96 ILEVAALVSLGLSFYKPADEDAPVLQEEEEHHGWIEGLAILISVIVVVIVTAFNDYSKERQFRGL 160
            :|..:|.||:.:..|    :||               ::|.::|::||.|....:|..|:....|
 Worm   147 LLLASAFVSIVMKQY----DDA---------------ISITVAVVIVVTVGFVQEYRSEKTLEQL 192

  Fly   161 QNRIEGE-HKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESD 224
            ...:... |   |:|.|:...:...:::.|||..:..||.:|:|..:.:|..|::||||||||::
 Worm   193 TKLVPPTCH---VLRDGKEAMMLARELVPGDIVLLNTGDRIPSDLRIAESFSLQIDESSLTGETE 254

  Fly   225 HVKK-----------GPDVDPM---VLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGAAVDEQE 275
            ...|           |.||:.:   ...||.|..|.|:.:|.:...|||.|
 Worm   255 PKHKETRSVPAASATGSDVEHLTCIAFMGTLVCAGRGRGIVISTAANSQFG-------------- 305

  Fly   276 AEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSESEGNHLPQSSSSGAAE 340
             |:.||                      :.|.::|
 Worm   306 -EVVKM----------------------MMGEESP------------------------------ 317

  Fly   341 TGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEKPWKNTYANNLVKHLI 405
                  |:.||..:..|..|:..  .:..|:.||.||..|               ...|:|....
 Worm   318 ------KTPLQKSMDDLGKQLSI--YSFGVIAVIFLIGMF---------------QGRNVVDMFT 359

  Fly   406 IGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMT 470
            |||::.|.|:|||||:.|.::||..|.:|.|...:|:.:.|.||:|..|.||||||||||.|.||
 Worm   360 IGVSLAVAAIPEGLPIVVAVTLAIGVMRMAKRRAVVKKMPAVETLGCVTVICSDKTGTLTKNEMT 424

  Fly   471 VVQSYICE-KLCKV----LPTLSDIPQHVG------------NLITMGISVNSAYTSNIMAGHNP 518
            .......| ||.::    ......:.|:.|            .:|..|:..|:|   .|.|..
 Worm   425 AQAIATPEGKLAEITGIGYSAEGGVVQYQGEQVHQWTHPEFARIIEAGLVCNNA---TIEADK-- 484

  Fly   519 GDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSMGTVIPRPNGGYRLY 583
                 .:|..||.|::  |.....:.:.:|.|.   |..|...|:|..|.||......:|....:
 Worm   485 -----LIGQPTEGAIV--VLAKKAQLEGVRSEY---KRLREMPFSSDTKWMGVQCADAHGQNVYF 539

  Fly   584 TKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISVAYRDFVPGKAAINE 648
            .|||.:.::.:|...|..:...::..:..::.:: |:.:.:...|||.:.:|
 Worm   540 IKGALDRVLDQCGTYYSSDNQRKQCDQYSRQHIL-EIGKELGQKGLRVLGLA------------- 590

  Fly   649 VHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIAS 713
               .||.        |.:|..|.::|:.||.||...|||...:.:|:.|:::|||.:.||:||..
 Worm   591 ---RGES--------MQSLMFLGMIGMMDPPRPGAADAISIVKASGVDVKLITGDAMETAQSIGQ 644

  Fly   714 KCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDSTV 778
            ..|||..:|.  .|.|::.::        :..|.::.|..::.|..|:||..|..:||.:
 Worm   645 SLGILSSSDS--CLSGQQVDQ--------MSDHDLELVIRQVTVFYRASPRHKLKIVKAL----- 694

  Fly   779 SENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYD 843
            ....||||:||||.||..||||||:|.|||:.||||.|||:|:||.||:||::..|:..|:.:|.
 Worm   695 QALGEVVAMTGDGVNDAVALKKADIGVAMGVCGTDVCKEAADMILCDDDFSTMTAAIEEGKAIYH 759

  Fly   844 SIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRK 908
            :|..|::|||:.:|.|:.:.........|:||.|:|:||:|:|||...:.:|..|....|::.::
 Worm   760 NITNFVRFQLSTSVAALSLIAASTMFKFDNPLNAMQILWINIIMDGPPAQSLGVEPVDDDIIRQR 824

  Fly   909 PYGRTKPLISRTMMKNILGQALYQLIIIFGLL--FVGDVILDIESGRGQELNAGPTQHFTIIFNT 971
            |....:|:::..::.:||..|   .||:.|.|  |..::..|         |....:..|:.|..
 Worm   825 PRNTKQPMLTGKLIADILASA---AIIVVGTLSVFYKEMSAD---------NKVTPRDTTMTFTC 877

  Fly   972 FVMMTLFNEINARKIHGQRNVI--EGLLTNPIFYTIWIFTMISQVLIIQYGKM--AFSTKALTLD 1032
            ||:..::|.::.|   ..|.:|  .||..|.:|......::|.|:|:|.:..:  .|.|:||:|.
 Worm   878 FVLFDMWNALSCR---SSRKMIWQIGLRRNRMFSLAVSASLICQLLVIYWAPLQHIFQTEALSLF 939

  Fly  1033 QWLWCIFFGIGTLVWGQLITSVPTRKLPKILSWGRGH 1069
            ..::.      |.:...:.....|||...:.|....|
 Worm   940 DLIFL------TTITSSVFIFNETRKYFSLRSKSLNH 970

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	284/1063 (27%)
		Cation_ATPase_N	36..104	CDD:279080	17/70 (24%)
		E1-E2_ATPase	172..448	CDD:278548	70/289 (24%)
		Cation_ATPase	505..598	CDD:289987	23/92 (25%)
		HAD_like	676..807	CDD:119389	48/130 (37%)
		Cation_ATPase_C	873..1051	CDD:279079	47/183 (26%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
pmr-1	NP_001021862.1	ATPase-IIA2_Ca	81..967	CDD:130585	288/1072 (27%)
		Cation_ATPase_N	98..155	CDD:279080	14/58 (24%)
		E1-E2_ATPase	181..402	CDD:278548	74/313 (24%)
		Cation_ATPase	474..554	CDD:289987	23/94 (24%)
		HAD_like	610..723	CDD:119389	46/127 (36%)
		Cation_ATPase_C	790..961	CDD:279079	50/191 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920