DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PMCA and Atp2c1

DIOPT Version :9

Sequence 1:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster
Sequence 2:	XP_038936656.1	Gene:	Atp2c1 / 170699	RGDID:	621311	Length:	983	Species:	Rattus norvegicus

Alignment Length:	1091	Identity:	286/1091 - (26%)
Similarity:	480/1091 - (43%)	Gaps:	245/1091 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 KIAENGGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSN---VIPPKPPKTFLTLVWE----AL 89
            |.|....:.|:...|......||  :|::..|||...|.|   :...:|       :|:    ..
  Rat    58 KRASELAVSEVAGLLQADLQNGL--NKSEVSHRRAFHGWNEFDISEDEP-------LWKKYISQF 113

  Fly    90 QDVTLIILEVAALVSLGLSFYKPADEDAPVLQEEEEHHGWIEGLAILISVIVVVIVTAFNDYSKE 154
            ::..:::|..:|::|              ||..:.:     :.::|.:::::||.|....:|..|
  Rat   114 KNPLIMLLLASAVIS--------------VLMRQFD-----DAVSITVAILIVVTVAFVQEYRSE 159

  Fly   155 RQFRGLQNRIEGE-HKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESS 218
            :....|...:..| |   .:|.|::......|::.||...:..||.:|||..|.::.||.:||||
  Rat   160 KSLEELSKLVPPECH---CVREGKLEHTLARDLVPGDTVCLSVGDRVPADLRLFEAVDLSIDESS 221

  Fly   219 LTGESDHVKKGPDVDP------------MVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGAAV 271
            ||||:....|.....|            :...||.|..|..|.:|...|.||:.|.:|.::.|
  Rat   222 LTGETTPCSKVTAPQPAATNGDLASRSNIAFMGTLVRCGKAKGIVIGTGENSEFGEVFKMMQA-- 284

  Fly   272 DEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSESEGNHLPQSSSS 336
                                               .:||
  Rat   285 -----------------------------------EEAP-------------------------- 288

  Fly   337 GAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEKPWKNTYANNLV 401
                      |:.||..:..|..|:.:  .:..::.:|:|:             .|  ....:::
  Rat   289 ----------KTPLQKSMDLLGKQLSF--YSFGIIGIIMLV-------------GW--LLGKDIL 326

  Fly   402 KHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTT 466
            :...|.|::.|.|:|||||:.||::||..|.:|:|...:|:.|...||:|....||||||||||.
  Rat   327 EMFTISVSLAVAAIPEGLPIVVTVTLALGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTK 391

  Fly   467 NRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISV----NSAYTSNIMAGHNPGDLPIQ--- 524
            |.|||......:.|...:..:.  ....|.:|..|..|    |.|.:..:.||....|..|:
  Rat   392 NEMTVTHILTSDGLHAEVTGVG--YNQFGEVIVDGDVVHGFYNPAVSRIVEAGCVCNDAVIRNNT 454

  Fly   525 -VGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRV-YTFNSVRKSMG------TVIPRPNGGYR 581
             :|..||.||:.....:|:      |.:.:|...:. |.|:|.:|.|.      |...||.   .
  Rat   455 LMGKPTEGALIALAMKMGL------DGLQQDYIRKAEYPFSSEQKWMAVKCVHRTQQDRPE---I 510

  Fly   582 LYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISVAYRDFVPGKAAI 646
            .:.|||.|.::|.|. .|..:|.....|: .|..|.::....|...|||.:::|
  Rat   511 CFMKGAYEQVIKYCT-TYNSKGQTLALTQ-QQRDLYQQEKAQMGSAGLRVLALA----------- 562

  Fly   647 NEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSI 711
                  ..|:       :..||.|.:|||.||.|..|.:|:.....:|::::|:|||:..||.:|
  Rat   563 ------SGPD-------LGQLTFLGLVGIIDPPRTGVKEAVTTLIASGVSIKMITGDSQETAIAI 614

  Fly   712 ASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDS 776
            ||:.|:......  .:.|:|.:..      :: ||| .::.||:.|..|:||..|..::|
  Rat   615 ASRLGLYSKTSQ--SVSGEEVDTM------EV-QHL-SQIVPKVAVFYRASPRHKMKIIK----- 664

  Fly   777 TVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNV 841
            ::.:|..|||:||||.||..|||.||:|.|||..||||.|||:|:||.||:|.:|:.|:..|:.:
  Rat   665 SLQKNGSVVAMTGDGVNDAVALKAADIGVAMGQTGTDVCKEAADMILVDDDFQTIMSAIEEGKGI 729

  Fly   842 YDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLL 906
            |::|..|::|||:.::.|:.:..:.......:||.|:|:||:|:|||...:.:|..| |....::
  Rat   730 YNNIKNFVRFQLSTSIAALTLISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVE-PVDKDVI 793

  Fly   907 RKPYGRTKPLISRTMMKNILGQALY-QLIIIFGLLFVGDVILDIESGRGQEL--NAGPTQHFTII 968
            |||....|..|   :.||::.:.|. .:||:.|.|||          ..:||  |....:..|:.
  Rat   794 RKPPRNWKDSI---LTKNLILKILVSSIIIVCGTLFV----------FWRELRDNVITPRDTTMT 845

  Fly   969 FNTFVMMTLFNEINARKIHGQRNVIE-GLLTNPIFYTIWIFTMISQVLIIQYGKM--AFSTKALT 1030
            |..||...:||.:::|.  ..::|.| ||.:|.:|....:.:::.|:|:|.:..:  .|.|::|:
  Rat   846 FTCFVFFDMFNALSSRS--QTKSVFEIGLCSNKMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLS 908

  Fly  1031 LDQWLWCIFFGIGTLVWGQLI--------------TSVPTRKLPKILSWGR 1067
            :...|:.:.......:..::|              ||.|:..| ::..|.|
  Rat   909 ILDLLFLLGLTSSVCIVSEIIKKVERSREKTQKNATSTPSSFL-EVWLWQR 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	283/1079 (26%)
		Cation_ATPase_N	36..104	CDD:279080	14/74 (19%)
		E1-E2_ATPase	172..448	CDD:278548	63/287 (22%)
		Cation_ATPase	505..598	CDD:289987	28/103 (27%)
		HAD_like	676..807	CDD:119389	45/130 (35%)
		Cation_ATPase_C	873..1051	CDD:279079	50/183 (27%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
Atp2c1	XP_038936656.1	P-type_ATPase_SPCA	88..930	CDD:319779	271/1028 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920