DRSC/TRiP Functional Genomics Resources

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Protein Alignment PMCA and Atp4a

DIOPT Version :9

Sequence 1:NP_001014689.3 Gene:PMCA / 43787 FlyBaseID:FBgn0259214 Length:1255 Species:Drosophila melanogaster
Sequence 2:NP_001277556.1 Gene:Atp4a / 11944 MGIID:88113 Length:1034 Species:Mus musculus


Alignment Length:1174 Identity:301/1174 - (25%)
Similarity:489/1174 - (41%) Gaps:327/1174 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 RELMEHRGREGVMKIAENG-GIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVIPPKPPK--- 79
            :|.:|:..:|  |:|.::. .:.||.:|..||..:||..|.|.|...|:  |.|.:  :||:   
Mouse    39 KEKLENMKKE--MEINDHQLSVSELEQKYQTSATKGLKASLAAELLLRD--GPNAL--RPPRGTP 97

  Fly    80 ---TFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVLQEEEEHHGWIEGLAILISVIV 141
               .|...:...||    .::.|||.:.| ::|         .:|..|......:.|.:.:::|.
Mouse    98 EYVKFARQLAGGLQ----CLMWVAAAICL-IAF---------AIQASEGDLTTDDNLYLAVALIA 148

  Fly   142 VVIVTA----FNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPA 202
            ||:||.    :.::.........:|.:  ..:.:|||.|:..||:...::|||:.::|.||.:||
Mouse   149 VVVVTGCFGYYQEFKSTNIIASFKNLV--PQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPA 211

  Fly   203 DGCLIQSNDLKVDESSLTGESDHVKKGPDV---DPM-----VLSGTHVMEGSGKMVVTAVGVNSQ 259
            |..::.:...|||.|||||||:...:.|:.   .|:     ....|..:||:.:.:|.:.|..:.
Mouse   212 DIRILSAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTAQGLVVSTGDRTI 276

  Fly   260 AGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSE 324
            .|.|.:|                                                          
Mouse   277 IGRIASL---------------------------------------------------------- 283

  Fly   325 SEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVI----ILIIQFCI-KT 384
                           .:|.:.||       |.:||:|.:....||.|.::    ..::..|| .|
Mouse   284 ---------------ASGVENEK-------TPIAIEIEHFVDIIAGLAILFGATFFVVAMCIGYT 326

  Fly   385 FVIDEKPWKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACET 449
            |               ::.::..:.::|..|||||...||:.|:.:.|::...|.:|::|:|.||
Mouse   327 F---------------LRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVET 376

  Fly   450 MGNATAICSDKTGTLTTNRMTV------------------------VQSYICEKLCKVLPTLSDI 490
            :|:.:.||||||||||.|||||                        ..|.....||:|| ||.: 
Mouse   377 LGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVL-TLCN- 439

  Fly   491 PQHVGNLITMGISVNSAYTSNIMAGHNPGDLP--IQVGNKTECALLGFVQ---GLGVKYQSIRDE 550
                          .:|:.|    |.:...:|  |.:|:.:|.|||.|.:   |..:.|:     
Mouse   440 --------------RAAFKS----GQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYR----- 481

  Fly   551 ITEDKFTRV--YTFNSVRK---SMGTVIPRPNGGYRLYTKGASEIIMKKCA--FIYGHEGTLEKF 608
               |:|.:|  ..|||:.|   |:.|:....:..:.|..|||.|.::::|:  .|.|.|..|::.
Mouse   482 ---DRFPKVCEIPFNSINKFQLSIHTLEDPRDSRHLLVMKGAPERVLERCSSILIKGQELPLDEQ 543

  Fly   609 TRD-----------MQERLIREVIEPMACDGLRTISVAYRDFVPGKAAINEVHIDGEPNWDDEEN 662
            .|:           :.||::          |...:.:..:|:.||.|.             |.|.
Mouse   544 WREAFQTAYLSLGGLGERVL----------GFCQLYLNEKDYPPGYAF-------------DVEA 585

  Fly   663 IMTNLTCLCVVGIE---DPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDDF 724
            :....:.||..|:.   ||.|..||||:.||:.|||.|.|||||:..||::||:..||       
Mouse   586 MNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGI------- 643

  Fly   725 LILEGKE---------------FNRR-----------IRDSNGDIQQHLID--KVWPKLRVLARS 761
             |.||.|               .||:           ::|.:   ...|::  :..|:: |.||:
Mouse   644 -ISEGSETVEDIAARLRMPVDQVNRKDARACVINGMQLKDMD---PSELVEALRTHPEM-VFART 703

  Fly   762 SPTDKYTLVKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDD 826
            ||..|..:|:     :......:|||||||.||.|||||||:|.||||||:|.||.|:|:||.||
Mouse   704 SPQQKLVIVE-----SCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDD 763

  Fly   827 NFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLA 891
            ||:|||..|..||.::|::.|.:.:.||.|:..:....|........||..:.:|::.|..|...
Mouse   764 NFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFP 828

  Fly   892 SLALATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIII------------------FG 938
            |::||.|....|::..:|   ..|...|.:.:.:...:.:|:..|                  |.
Mouse   829 SVSLAYEKAESDIMHLRP---RNPKRDRLVNEPLAAYSYFQIGAIQSFAGFADYFTAMAQEGWFP 890

  Fly   939 LLFVG-------DVILDIESGRGQELNAGPT--QHFT--IIFNTFVMMTLFNEINARKIHGQRNV 992
            ||.||       ..:.|::...|||...|..  |.:|  .:|...:.|....::..||.......
Mouse   891 LLCVGLRPQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEMCQIADVLIRKTRRLSVF 955

  Fly   993 IEGLLTNPIFYTIWIFTMISQVLIIQYGKM--AFSTKALTLDQWLWCIFFGIGTLVWGQLITSVP 1055
            .:|...|.|.....:|.:.....:.....|  .|:...:....||..:.||:...|:.::     
Mouse   956 QQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPMPFGLLIFVYDEI----- 1015

  Fly  1056 TRKL 1059
             |||
Mouse  1016 -RKL 1018

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
PMCANP_001014689.3 ATPase-IIB_Ca 1..1057 CDD:273668 298/1170 (25%)
Cation_ATPase_N 36..104 CDD:279080 21/74 (28%)
E1-E2_ATPase 172..448 CDD:278548 63/288 (22%)
Cation_ATPase 505..598 CDD:289987 28/104 (27%)
HAD_like 676..807 CDD:119389 57/161 (35%)
Cation_ATPase_C 873..1051 CDD:279079 42/208 (20%)
ATP_Ca_trans_C 1096..1142 CDD:289209
Atp4aNP_001277556.1 H-K_ATPase_N 2..>27 CDD:286172