Protein Alignment PMCA and Atp2b2

DIOPT Version :10

• Sequence 1: NP_001014689.3
• Gene: PMCA / 43787
• FlyBaseID: FBgn0259214
• Length: 1255
• Species: Drosophila melanogaster
• Sequence 2: XP_030110982.1
• Gene: Atp2b2 / 11941
• MGIID: 105368
• Length: 1272
• Species: Mus musculus
• Alignment Length: 1282
• Identity: 742/1282 - (57%)
• Similarity: 890/1282 - (69%)
• Gaps: 128/1282 - (9%)

  Fly    10 QYGISLKQLRELMEHRGREGVMKIAEN-GGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVI 73
            ::|.::::||.|||.||.|.|:||.|. |....:|::|.|||.|||.|:..|.|.|::.||.|.|
Mouse    23 EFGCTMEELRSLMELRGTEAVVKIKETYGDTEAICRRLKTSPVEGLPGTAPDLEKRKQIFGQNFI 87

  Fly    74 PPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKP---ADEDAPVLQ-----EEEEHHGWI 130
            |||.|||||.|||||||||||||||:||::|||||||.|   ::|.....|     |.|...|||
Mouse    88 PPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGESNEGCATAQGGAEDEGEAEAGWI 152

  Fly   131 EGLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVK 195
            ||.|||:|||.||:||||||:|||:||||||:|||.|.||:|:|.|:|.||.|.:|:||||||:|
Mouse   153 EGAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRAGQVVQIPVAEIVVGDIAQIK 217

  Fly   196 YGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVNSQA 260
            |||||||||..||.||||:||||||||||.|:|..|.|||:|||||||||||:|||||||||||.
Mouse   218 YGDLLPADGLFIQGNDLKIDESSLTGESDQVRKSVDKDPMLLSGTHVMEGSGRMVVTAVGVNSQT 282

  Fly   261 GIIFTLLGAAVDEQEAEIKKMKKEAKRAN----------KQKNLTGE----------NDGRSQIK 305
            |||||||||..:|:|   ||.||..|:.:          ...|..|.          .||.:...
Mouse   283 GIIFTLLGAGGEEEE---KKDKKGVKKGDGLQIPAADGAAPANAAGSANASLVNGKMQDGSADSS 344

  Fly   306 GSQAPSQRETVTSEITKSES-EGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIA 369
            .|:|..|......|:...:| ||........:..    |||||||||.||||||:|||.||..::
Mouse   345 QSKAKQQDGAAAMEMQPLKSAEGGDADDKKKANM----HKKEKSVLQGKLTKLAVQIGKAGLVMS 405

  Fly   370 VLTVIILIIQFCIKTFVIDEKPWKN----TYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYS 430
            .:|||||::.|.:.|||:::|||..    .|....||..||||||||||||||||||||:|||||
Mouse   406 AITVIILVLYFTVDTFVVNKKPWLTECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYS 470

  Fly   431 VKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVG 495
            |||||||||||||||||||||||||||||||||||||||||||:|:.:...|.:|..|.|.....
Mouse   471 VKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQAYVGDVHYKEIPDPSSINAKTL 535

  Fly   496 NLITMGISVNSAYTSNIMAGHNPGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVY 560
            .|:...|::|||||:.|:.....|.||.||||||||.|||||..|...|:.:|.::.|:|..:||
Mouse   536 ELLVNAIAINSAYTTKILPPEKEGALPRQVGNKTECGLLGFVLDLRQDYEPVRSQMPEEKLYKVY 600

  Fly   561 TFNSVRKSMGTVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMA 625
            |||||||||.|||..|:..:|:|:||||||::|||..|....|....|....::.::::||||||
Mouse   601 TFNSVRKSMSTVIKMPDESFRMYSKGASEIVLKKCCKILSGAGEARVFRPRDRDEMVKKVIEPMA 665

  Fly   626 CDGLRTISVAYRDFVPGKAAINEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKC 690
            |||||||.|||||| |...         ||:||:|.:|:..|||:||||||||||||||:|||||
Mouse   666 CDGLRTICVAYRDF-PSSP---------EPDWDNENDILNELTCICVVGIEDPVRPEVPEAIRKC 720

  Fly   691 QRAGITVRMVTGDNINTARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKL 755
            |||||||||||||||||||:||.||||:.|.:|||.|||||||||||:..|:|:|..|||:||||
Mouse   721 QRAGITVRMVTGDNINTARAIAIKCGIIHPGEDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKL 785

  Fly   756 RVLARSSPTDKYTLVKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASD 820
            |||||||||||:||||||||||.:|.|:|||||||||||||||||||||||||||||||||||||
Mouse   786 RVLARSSPTDKHTLVKGIIDSTHTEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASD 850

  Fly   821 IILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNL 885
            |||||||||||||||||||||||||:||||||||||||||||||.|||..|||||||||||||||
Mouse   851 IILTDDNFSSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNL 915

  Fly   886 IMDTLASLALATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIE 950
            ||||.||||||||.||..|||||||||.||||||||||||||.|:|||.:||.|||||:.:..|:
Mouse   916 IMDTFASLALATEPPTETLLLRKPYGRNKPLISRTMMKNILGHAVYQLTLIFTLLFVGEKMFQID 980

  Fly   951 SGRGQELNAGPTQHFTIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVL 1015
            |||...|::.|::|:||||||||||.||||||||||||:|||.:|:..||||.||.:.|...|::
Mouse   981 SGRNAPLHSPPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFRNPIFCTIVLGTFAIQIV 1045

  Fly  1016 IIQYGKMAFSTKALTLDQWLWCIFFGIGTLVWGQLITSVPTRKLPKILSWGRGHPEEYTDGMNLG 1080
            |:|:|...||...|.||||:||||.|:|.|||||:|.::||.:|..:...||...:|......|.
Mouse  1046 IVQFGGKPFSCSPLQLDQWMWCIFIGLGELVWGQVIATIPTSRLKFLKEAGRLTQKEEIPEEELN 1110

  Fly  1081 EERFDSID-SDKKPRAGQILWIRGLTRLQTQ-----------------------------LRVIR 1115
            |: .:.|| ::::.|.|||||.|||.|:|||                             :||::
Mouse  1111 ED-VEEIDHAERELRRGQILWFRGLNRIQTQIEVVNTFKSGASFQGALRRQSSVTSQSQDIRVVK 1174

  Fly  1116 AFRSTL-EDLNERRSMHSLHSLRSPRTGIPVAVGGGHPLYNFNLLNPNYIKHQQQQEPKLPPQTQ 1179
            ||||:| |.|.:..|..|:|                           |::.|         |:.:
Mouse  1175 AFRSSLYEGLEKPESRTSIH---------------------------NFMAH---------PEFR 1203

  Fly  1180 LNVSSGMMSPDISYIDEDPQQQQRTLHNGLTSQRSSMPSNVPSSNQS 1226
            :..|    .|.|..||:...::...|     .|.||.||::..:|.:
Mouse  1204 IEDS----QPHIPLIDDTDLEEDAAL-----KQNSSPPSSLNKNNSA 1241

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	P-type_ATPase_Ca_PMCA-like	62..921	CDD:319776	586/891 (66%)
		Cation_ATPase_C	873..1051	CDD:376368	123/177 (69%)
		ATP_Ca_trans_C	1096..1141	CDD:463575	24/74 (32%)
Atp2b2	XP_030110982.1	ATPase-IIB_Ca	12..1087	CDD:273668	693/1080 (64%)
		ATP_Ca_trans_C	1126..1201	CDD:463575	26/110 (24%)