DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PMCA and Atp2a2

DIOPT Version :9

Sequence 1:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster
Sequence 2:	NP_001103610.1	Gene:	Atp2a2 / 11938	MGIID:	88110	Length:	1044	Species:	Mus musculus

Alignment Length:	1141	Identity:	313/1141 - (27%)
Similarity:	491/1141 - (43%)	Gaps:	263/1141 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 KQLRELMEHRGREGVMKIAENGGIH-ELCKKLYTSPNEGLSGSKADEEHRRETFGSNVIPPKPPK 79
            |.:.|::.|.|      :.|:.|:. |..|||                  :|.:|||.:|.:..|
Mouse     7 KTVEEVLGHFG------VNESTGLSLEQVKKL------------------KERWGSNELPAEEGK 47

  Fly    80 TFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVLQEEEEHHGWIEGLAILISVIVVVI 144
            |.|.||.|..:|:.:.||.:||.:|..|::::         :.||....::|...||:.::...|
Mouse    48 TLLELVIEQFEDLLVRILLLAACISFVLAWFE---------EGEETITAFVEPFVILLILVANAI 103

  Fly   145 VTAFNDYSKERQFRGLQNRIEGEHKFSVIRG-------GEVCQISVGDILVGDIAQVKYGDLLPA 202
            |..:       |.|..:|.||...::....|       ..|.:|...||:.|||.::..||.:||
Mouse   104 VGVW-------QERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPA 161

  Fly   203 DGCL--IQSNDLKVDESSLTGESDHVKKGPDVDP-----------MVLSGTHVMEGSGKMVVTAV 254
            |..|  |:|..|:||:|.|||||..|.|..|..|           |:.|||::..|....||.|.
Mouse   162 DIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVAT 226

  Fly   255 GVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSE 319
            |||::.|.|                                                :.|.|.:|
Mouse   227 GVNTEIGKI------------------------------------------------RDEMVATE 243

  Fly   320 ITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKT 384
                                     :|::.||.||.:...|:....|.|.:...||.|..|
Mouse   244 -------------------------QERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHF---- 279

  Fly   385 FVIDEKPWKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACET 449
               ::.....::....:.:..|.|.:.|.|:|||||..:|..||...::|.|.|.:||.|.:.||
Mouse   280 ---NDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVET 341

  Fly   450 MGNATAICSDKTGTLTTNRMTVVQSYICEKL----CKV----------LP----TLSDIP----Q 492
            :|..:.||||||||||||:|:|.:.:|.:|:    |.:          .|    ...|.|    |
Mouse   342 LGCTSVICSDKTGTLTTNQMSVCRMFILDKVEGDTCSLNEFSITGSTYAPIGEVQKDDKPVKCHQ 406

  Fly   493 HVG--NLITM-GISVNSAYTSNIMAGHNPGDLPIQVGNKTECALLGFVQGLGV------------ 542
            :.|  .|.|: .:..:||...|...|     :..:||..||.||...|:.:.|
Mouse   407 YDGLVELATICALCNDSALDYNEAKG-----VYEKVGEATETALTCLVEKMNVFDTELKGLSKIE 466

  Fly   543 ---KYQSIRDEITEDKFTRVYTFNSVRKSMGTVIPRPNGGYR-----LYTKGASEIIMKKCAFI- 598
               ...|:..::.:.:||  ..|:..|||| :|...||...|     ::.|||.|.::.:|..|
Mouse   467 RANACNSVIKQLMKKEFT--LEFSRDRKSM-SVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIR 528

  Fly   599 YGHEGTLEKFTRDMQERLIREVIE-PMACDGLRTISVAYRDFVPGKAAINEVHIDGEPNWDDEEN 662
            .|  .|....|..::::::..:.| ....|.||.:::|..| .|.|.  .|:|::...|:...|
Mouse   529 VG--STKVPMTPGVKQKIMSVIREWGSGSDTLRCLALATHD-NPLKR--EEMHLEDSANFIKYE- 587

  Fly   663 IMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDDFL-- 725
              ||||.:..||:.||.|.||..:::.|::|||.|.|:||||..||.:|..:.||...::|..
Mouse   588 --TNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSK 650

  Fly   726 ILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDSTVSENREVVAVTGD 790
            ...|:||:.....:..|        .....|..||..|:.|..:|:     .:....|:.|:|||
Mouse   651 AFTGREFDELSPSAQRD--------ACLNARCFARVEPSHKSKIVE-----FLQSFDEITAMTGD 702

  Fly   791 GTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTV 855
            |.||.|||||:::|.||| :||.|||.||:::|.|||||:||.||..||.:|:::.:|:::.::.
Mouse   703 GVNDAPALKKSEIGIAMG-SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISS 766

  Fly   856 NVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISRT 920
            ||..|:..|:.|.......|..||:|||||:.|.|.:.||....|..|::.:.|....:||||..
Mouse   767 NVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGW 831

  Fly   921 MMKNILGQALYQLIIIFGLLFVGDVI-LDIESGRGQELNAGPTQHF------------------- 965
            :....|....|     .|...||... ..|.:..|..::.....||
Mouse   832 LFFRYLAIGCY-----VGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFDGVDCAIFE 891

  Fly   966 -----TIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMIS-------QVLIIQ 1018
                 |:..:..|.:.:.|.:|:...:      :.||..|.:..||:...|.       .:|.::
Mouse   892 SPYPMTMALSVLVTIEMCNALNSLSEN------QSLLRMPPWENIWLVGSICLSMSLHFLILYVE 950

  Fly  1019 YGKMAFSTKALTLDQWLWCIFFGIGTLVWGQLITSV 1054
            ...:.|....|.|.|||..:...:..::..:.:..|
Mouse   951 PLPLIFQITPLNLTQWLMVLKISLPVILMDETLKFV 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	313/1141 (27%)
		Cation_ATPase_N	36..104	CDD:279080	21/68 (31%)
		E1-E2_ATPase	172..448	CDD:278548	75/295 (25%)
		Cation_ATPase	505..598	CDD:289987	29/112 (26%)
		HAD_like	676..807	CDD:119389	45/132 (34%)
		Cation_ATPase_C	873..1051	CDD:279079	45/209 (22%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
Atp2a2	NP_001103610.1	Cation_ATPase_N	4..72	CDD:279080	26/88 (30%)
		ATPase-IIA1_Ca	53..988	CDD:273452	294/1071 (27%)
		E1-E2_ATPase	93..340	CDD:278548	84/333 (25%)
		Cation_ATPase	419..527	CDD:289987	29/115 (25%)
		Interaction with HAX1. /evidence=ECO:0000250	575..594		7/21 (33%)
		HAD	<605..711	CDD:289480	38/118 (32%)
		Cation_ATPase_C	783..986	CDD:279079	45/213 (21%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	787..807		10/19 (53%)
		Interaction with TMEM64 and PDIA3. /evidence=ECO:0000269\|PubMed:23395171	788..1044		45/210 (21%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	931..942		2/10 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010