Protein Alignment PMCA and Atp2a1

DIOPT Version :9

• Sequence 1: NP_001014689.3
• Gene: PMCA / 43787
• FlyBaseID: FBgn0259214
• Length: 1255
• Species: Drosophila melanogaster
• Sequence 2: NP_031530.2
• Gene: Atp2a1 / 11937
• MGIID: 105058
• Length: 994
• Species: Mus musculus
• Alignment Length: 1145
• Identity: 305/1145 - (26%)
• Similarity: 479/1145 - (41%)
• Gaps: 285/1145 - (24%)

  Fly    31 MKIAENGGIHELCKKLYTSPNEGLSGSKADEEHRR-ETFGSNVIPPKPPKTFLTLVWEALQDVTL 94
            |:.|.:....|.......|...||:   .|:..|. |.:|.|.:|.:..|:...||.|..:|:.:
Mouse     1 MEAAHSKSTEECLSYFGVSETTGLT---PDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLV 62

  Fly    95 IILEVAALVSLGLSFYKPADEDAPVLQEEEEHHGWIEGLAILISVIVVVIVTAFNDYSKERQFRG 159
            .||.:||.:|..|::::         :.||....::|...||:.:|...||..:       |.|.
Mouse    63 RILLLAACISFVLAWFE---------EGEETVTAFVEPFVILLILIANAIVGVW-------QERN 111

  Fly   160 LQNRIEGEHKFSVIRG-------GEVCQISVGDILVGDIAQVKYGDLLPADGCL--IQSNDLKVD 215
            .:|.||...::....|       ..|.:|...||:.|||.:|..||.:|||..:  |:|..|:||
Mouse   112 AENAIEALKEYEPEMGKVYRADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILSIKSTTLRVD 176

  Fly   216 ESSLTGESDHVKKGPDVDP-----------MVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGA 269
            :|.|||||..|.|..|..|           |:.|||::..|....:|...||:::.|.|
Mouse   177 QSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKI------ 235

  Fly   270 AVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSESEGNHLPQSS 334
                                           |.|:..::
Mouse   236 -------------------------------RDQMAATE-------------------------- 243

  Fly   335 SSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEKPWKNTYANN 399
                      ::|:.||.||.:...|:....|.|.|...:|.|..|       ::.....::...
Mouse   244 ----------QDKTPLQQKLDEFGEQLSKVISLICVAVWLINIGHF-------NDPVHGGSWFRG 291

  Fly   400 LVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTL 464
            .:.:..|.|.:.|.|:|||||..:|..||...::|.|.|.:||.|.:.||:|..:.|||||||||
Mouse   292 AIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTL 356

  Fly   465 TTNRMTVVQSYICEK----LC----------------KVLPTLSDIPQHVG---NLITMGISVNS 506
            |||:|:|.:.:|.:|    :|                :||.  :|.|...|   .|:.:
Mouse   357 TTNQMSVCKMFIIDKVDGDVCSLNEFSITGSTYAPEGEVLK--NDKPVRAGQYDGLVEL------ 413

  Fly   507 AYTSNIMAGHNPGDLPI--------QVGNKTECALLGFVQGLGVKYQSIRD-------------- 549
               :.|.|..|...|..        :||..||.||...|:.:.|....:|.
Mouse   414 ---ATICALCNDSSLDFNETKGVYEKVGEATETALTTLVEKMNVFNTEVRSLSKVERANACNSVI 475

  Fly   550 -EITEDKFTRVYTFNSVRKSMGTVI-----PRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLE-K 607
             ::.:.:||  ..|:..||||....     .|...|.:::.|||.|.::.:|.::  ..||.. .
Mouse   476 RQLMKKEFT--LEFSRDRKSMSVYCSPAKSSRAAVGNKMFVKGAPEGVIDRCNYV--RVGTTRVP 536

  Fly   608 FTRDMQERLIREVIE-PMACDGLRTISVAYRDFVPGKAAINEVHIDGEPNWDDEENIMTNLTCLC 671
            .|..::|:::..:.| ....|.||.:::|.||..|.:   .|:.:|....:.:.|   .:||.:.
Mouse   537 LTGPVKEKIMSVIKEWGTGRDTLRCLALATRDTPPKR---EEMVLDDSAKFMEYE---MDLTFVG 595

  Fly   672 VVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPN-------------DD 723
            |||:.||.|.||..:|:.|:.|||.|.|:||||..||.:|..:.||...|             ||
Mouse   596 VVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFSENEEVTDRAYTGREFDD 660

  Fly   724 FLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDSTVSENREVVAVT 788
            ..:.|.:|..||                   ....||..|:.|..:|:     .:....|:.|:|
Mouse   661 LPLAEQREACRR-------------------ACCFARVEPSHKSKIVE-----YLQSYDEITAMT 701

  Fly   789 GDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQL 853
            |||.||.||||||::|.||| :||.|||.||:::|.|||||:||.||..||.:|:::.:|:::.:
Mouse   702 GDGVNDAPALKKAEIGIAMG-SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLI 765

  Fly   854 TVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLIS 918
            :.||..|:..|:.|.......|..||:|||||:.|.|.:.||....|..|::.|.|....:||||
Mouse   766 SSNVGEVVCIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLIS 830

  Fly   919 RTMMKNILGQALYQLIIIFGLLFVGDVILDIESGRGQELNAGP-------------TQH------ 964
                    |...::.:.|.|  :||...:...:........||             |:|
Mouse   831 --------GWLFFRYMAIGG--YVGAATVGAAAWWFLYAEDGPHVSYHQLTHFMQCTEHNPEFDG 885

  Fly   965 -----------FTIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMIS------ 1012
                       .|:..:..|.:.:.|.:|:...:      :.||..|.:..||:...|.
Mouse   886 LDCEVFEAPEPMTMALSVLVTIEMCNALNSLSEN------QSLLRMPPWVNIWLLGSICLSMSLH 944

  Fly  1013 -QVLIIQYGKMAFSTKALTLDQWLWCIFFGIGTLVWGQLI 1051
             .:|.:....|.|..:||...|||..:...:..:...:|:
Mouse   945 FLILYVDPLPMIFKLRALDFTQWLMVLKISLPVIGLDELL 984

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	305/1145 (27%)
		Cation_ATPase_N	36..104	CDD:279080	19/68 (28%)
		E1-E2_ATPase	172..448	CDD:278548	71/295 (24%)
		Cation_ATPase	505..598	CDD:289987	27/120 (23%)
		HAD_like	676..807	CDD:119389	48/143 (34%)
		Cation_ATPase_C	873..1051	CDD:279079	47/214 (22%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
Atp2a1	NP_031530.2	P-type_ATPase_SERCA	5..989	CDD:319778	303/1141 (27%)
		Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191	788..808		10/19 (53%)
		Interaction with PLN. /evidence=ECO:0000250|UniProtKB:P04191	932..943		2/10 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010