DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PMCA and atp2b2

DIOPT Version :9

Sequence 1:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster
Sequence 2:	XP_031752718.1	Gene:	atp2b2 / 100488346	XenbaseID:	XB-GENE-950177	Length:	1244	Species:	Xenopus tropicalis

Alignment Length:	1255	Identity:	730/1255 - (58%)
Similarity:	880/1255 - (70%)	Gaps:	111/1255 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YGISLKQLRELMEHRGREGVMKIAEN-GGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVIP 74
            :|.::..||||||.|..|.|.:|.:. ||:|.:|::|.|||.|||||:.:|.|.||:.||.|.||
Frog    23 FGCTIMDLRELMELRSAEAVNRIRDTYGGVHNICRRLKTSPVEGLSGNPSDLERRRQIFGKNFIP 87

  Fly    75 PKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADED--------APVLQEEEEHHGWIE 131
            ||..||||.|||||||||||||||:||::|||||||.|...|        |.|..|.|...||||
Frog    88 PKKAKTFLQLVWEALQDVTLIILEIAAIISLGLSFYHPPGGDNELCGEAAAGVEDEGEAQAGWIE 152

  Fly   132 GLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVKY 196
            |.|||.|||:||:||||||:|||:||||||:|||.|.||:|||.|:|.||.|.:::||||||:||
Frog   153 GAAILFSVIIVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRKGQVIQIPVAELVVGDIAQIKY 217

  Fly   197 GDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVNSQAG 261
            ||||||||.|||.||||:||||||||||.|||..:.|||:|||||||||||:|||||||||||.|
Frog   218 GDLLPADGILIQGNDLKIDESSLTGESDQVKKSLEKDPMLLSGTHVMEGSGRMVVTAVGVNSQTG 282

  Fly   262 IIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSESE 326
            ||||||||  :|...|.||.||..|        .|.::.|::.|.      ::.|..||...:||
Frog   283 IIFTLLGA--NEGGEEEKKSKKGKK--------PGPSENRNKAKA------QDGVALEIQPLKSE 331

  Fly   327 GNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEKP 391
            .....:.......:. .||||||||.|||:||:|||.||..::.:|||||::.|.|.||.:..:|
Frog   332 EGVECEEKEKKVVKV-PKKEKSVLQGKLTRLAVQIGKAGLIMSAITVIILVLYFVIYTFGVLGRP 395

  Fly   392 W----KNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGN 452
            |    ...|....||..||||||||||||||||||||:|||||||||||||||||||||||||||
Frog   396 WLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGN 460

  Fly   453 ATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISVNSAYTSNIMAGHN 517
            |||||||||||||.|||||||:::.....:.:|....:...:.:||..||||||||||.|:....
Frog   461 ATAICSDKTGTLTMNRMTVVQAFVGGTHYRQIPDPEALNTKILDLIVNGISVNSAYTSKILPPEK 525

  Fly   518 PGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSMGTVIPRPNGGYRL 582
            .|.||.||||||||||||||..|...||::|:||.|:...:|||||||||||.||:...:|.:|:
Frog   526 EGGLPRQVGNKTECALLGFVLDLKQDYQTVRNEIPEENLYKVYTFNSVRKSMSTVLCDSSGKFRM 590

  Fly   583 YTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISVAYRDFVPGKAAIN 647
            |:|||||||::||..|....|.:..|....::.::::|||||||||||||.:||||| |.
Frog   591 YSKGASEIILRKCTRILDQGGDVCPFKAKDRDEMVKKVIEPMACDGLRTICLAYRDF-PS----- 649

  Fly   648 EVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIA 712
                |.|||||:|.:|:::|.|:.|||||||||||||:||:|||||||||||||||||||||:||
Frog   650 ----DSEPNWDNEGDILSDLICIAVVGIEDPVRPEVPEAIQKCQRAGITVRMVTGDNINTARAIA 710

  Fly   713 SKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDST 777
            :|||||:|.:|||.|||||||..||:..|:::|..:|||||:||||||||||||:||||||||||
Frog   711 TKCGILQPGEDFLCLEGKEFNTLIRNEKGEVEQDKLDKVWPRLRVLARSSPTDKHTLVKGIIDST 775

  Fly   778 VSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVY 842
            |:|.|:|||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||
Frog   776 VAERRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVY 840

  Fly   843 DSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLR 907
            |||:||||||||||||||||||.|||..|||||||||||||||||||.||||||||.||..||||
Frog   841 DSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTDSLLLR 905

  Fly   908 KPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIESGRGQELNAGPTQHFTIIFNTF 972
            |||||.||||||||||||||.|:|||.|||.|||.|:...||:|||...|::.|::|:||:||||
Frog   906 KPYGRNKPLISRTMMKNILGHAVYQLTIIFTLLFAGEKFFDIDSGRNVPLHSPPSEHYTIVFNTF 970

  Fly   973 VMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAFSTKALTLDQWLWC 1037
            |||.||||||||||||:|||.|.:..||||..:.:.|..:|::|:::|...||...|||.||.||
Frog   971 VMMQLFNEINARKIHGERNVFENIFRNPIFCAVVLGTFGAQIIIVEFGGKPFSCSGLTLSQWFWC 1035

  Fly  1038 IFFGIGTLVWGQLITSVPTRKLPKILSWGRGHPEEYTDGMNLGEERFDSID-SDKKPRAGQILWI 1101
            ||.|:|.|:|||:|.::||.:|..:...|.|..:|......|.|: .|.|| ::.:.|.|||||.
Frog  1036 IFIGVGELLWGQMICTIPTSRLKFLKEAGHGPLKEDIQQEELTED-VDEIDHAEMELRRGQILWF 1099

  Fly  1102 RGLTRLQTQ---------------------------------------LRVIRAFRSTL-EDLNE 1126
            |||.|:|||                                       ::|:.||||:| |.|.:
Frog  1100 RGLNRIQTQMDVVYTFQTGGTSLQGALRRQPSTISQHLDAKHASSPTHIKVVNAFRSSLYEGLEK 1164

  Fly  1127 RRSMHSLHSLRSPRTGIPVAVGGGHPLYNFNLLNPNYIKHQQQQEPKLPPQTQLNVSSGMMSPDI 1191
            .:...::||..:            ||.:.             .:|....||.:.:.|.|..|..:
Frog  1165 PQIRSAIHSFMT------------HPEFT-------------PREAGPAPQFEDSDSEGEESKGL 1204

  Fly  1192 SYIDEDPQQQQRTLHNGLTS 1211
            |...:|    |...||..:|
Frog  1205 SKAHKD----QTHNHNNNSS 1220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	683/1058 (65%)
		Cation_ATPase_N	36..104	CDD:279080	45/68 (66%)
		E1-E2_ATPase	172..448	CDD:278548	166/279 (59%)
		Cation_ATPase	505..598	CDD:289987	56/92 (61%)
		HAD_like	676..807	CDD:119389	106/130 (82%)
		Cation_ATPase_C	873..1051	CDD:279079	119/177 (67%)
		ATP_Ca_trans_C	1096..1142	CDD:289209	22/85 (26%)
atp2b2	XP_031752718.1	ATPase-IIB_Ca	12..1055	CDD:273668	683/1058 (65%)
atp2b2	XP_031752718.1	ATP_Ca_trans_C	1094..1179	CDD:403580	23/96 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	259	1.000	Domainoid score	I1949
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1374	1.000	Inparanoid score	I132
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D115892at2759
OrthoFinder	1	1.000	-	-		FOG0000362
OrthoInspector	1	1.000	-	-		otm47598
Panther	1	1.100	-	-	O	PTHR24093
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X220
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160