Protein Alignment PMCA and atp2c1

DIOPT Version :9

• Sequence 1: NP_001014689.3
• Gene: PMCA / 43787
• FlyBaseID: FBgn0259214
• Length: 1255
• Species: Drosophila melanogaster
• Sequence 2: XP_002937789.2
• Gene: atp2c1 / 100487845
• XenbaseID: XB-GENE-968174
• Length: 961
• Species: Xenopus tropicalis
• Alignment Length: 1047
• Identity: 276/1047 - (26%)
• Similarity: 463/1047 - (44%)
• Gaps: 248/1047 - (23%)

  Fly    63 HRRETFGSN---VIPPKPPKTFLTLVW----EALQDVTLIILEVAALVSLGLSFYKPADEDAPVL 120
            |||...|.|   :...:|       :|    |..::..|::|..:|::|:             ::
 Frog    97 HRRAAHGWNEFDISEGEP-------LWKKYIEQFKNPLLMLLLASAVISI-------------LM 141

  Fly   121 QEEEEHHGWIEGLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGE-HKFSVIRGGEVCQISVG 184
            |:.:      :.::|.:::::||.|....:|..|:....|...:..| |   .||.|.:......
 Frog   142 QQFD------DAVSITVAILIVVTVAFVQEYRSEKSLEELSKLVPPECH---CIREGRMEHTLAR 197

  Fly   185 DILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDP------------MVL 237
            |::.||...:..||.:|||..|.::.||.|||||||||:....|.....|            :..
 Frog   198 DLVPGDTVCLTVGDRVPADLRLFEAMDLSVDESSLTGETAPCAKSTAPQPCASNGDLTSRSNIAF 262

  Fly   238 SGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRS 302
            .||.|..|..|.:|...|.||:.|.:|.::.|             :||.:...||::
 Frog   263 MGTLVRCGKAKGIVIGTGENSEFGEVFKMMQA-------------EEAPKTPLQKSM-------- 306

  Fly   303 QIKGSQAPSQRETVTSEITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGST 367
            .|.|.|                                                |::.      :
 Frog   307 DILGKQ------------------------------------------------LSLY------S 317

  Fly   368 IAVLTVIILIIQFCIKTFVIDEKPWKNTYANNLVKHLI----IGVTVLVVAVPEGLPLAVTLSLA 428
            ..::.||:|:             .|...      ||::    |||::.|.|:|||||:.||::||
 Frog   318 FGIIGVIMLV-------------GWLQG------KHILDMFTIGVSLAVAAIPEGLPIVVTVTLA 363

  Fly   429 YSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQH 493
            ..|.:|:|...:|:.|...||:|....||||||||||.|.|||...:..:.|...:..:.  ...
 Frog   364 LGVMRMVKKRAIVKKLPIVETLGCCNVICSDKTGTLTKNEMTVTHIFTSDGLHAEVTGVG--YNR 426

  Fly   494 VGNLITMGISV----NSAYTSNIMAGHNPGDLPIQ----VGNKTECALLGFVQGLGVKYQSIRDE 550
            .|.:|..|..:    |.:.:..|.||....|..|:    :|..||.||:.....:|:      :.
 Frog   427 FGEVIHDGEIIHGFCNPSISKVIEAGCVCNDAEIRNNTLMGKPTEGALIALSMKMGL------EA 485

  Fly   551 ITEDKFTRV-YTFNSVRKSMG------TVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLEKF 608
            :..|...|. |.|:|.:|.|.      |...:|.   ..:.|||.|.::|.|. .|..:|.....
 Frog   486 LRHDYIRRAEYPFSSEQKWMAVKCVHRTQQDKPE---ICFMKGAYEQVIKYCT-TYNSKGQTFPL 546

  Fly   609 TRDMQERLIREVIEPMACDGLRTISVAYRDFVPGKAAINEVHIDGEPNWDDEENIMTNLTCLCVV 673
            |:..:|..::|... |...|||.|::|                 ..|.       :..||.|.:|
 Frog   547 TQQQRELYLQETAY-MGTAGLRVIALA-----------------SGPE-------LGQLTFLGLV 586

  Fly   674 GIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDDFLILEGKEFNRRIRD 738
            |:.||.|..|.:|:....|:|:.::|:|||:..||.:|||:.|.              :::.::.
 Frog   587 GMIDPPRTGVKEAVSTLIRSGVAIKMITGDSQETAVAIASRLGF--------------YSKGLQS 637

  Fly   739 SNG------DIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDSTVSEN-REVVAVTGDGTNDGP 796
            .:|      ||||  :.::..|:.|..|:||..|..:||.:      :| ..|||:||||.||..
 Frog   638 LSGEDVDMMDIQQ--LSQMVSKVSVFYRASPRHKLKIVKSL------QNIGAVVAMTGDGVNDAV 694

  Fly   797 ALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVI 861
            |||.||:|.|||..||||.|||:|:||.:|:|.:|:.|:..|:.:|::|..|::|||:.::.|:.
 Frog   695 ALKAADIGIAMGKTGTDVCKEAADMILVEDDFQTIMSAIEEGKGIYNNIKNFVRFQLSTSIAALT 759

  Fly   862 VAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISRTMMKNIL 926
            :..:.......:||.|:|:||:|:|||...:.:|..|....|::.:.|......::::.::..||
 Frog   760 LISLATLMNFPNPLNAMQILWINIIMDGPPAQSLGVEPVDKDVIRKPPRNLKDSILTKNLIVKIL 824

  Fly   927 GQALYQLIIIFGLLFVGDVILDIESGRGQEL--NAGPTQHFTIIFNTFVMMTLFNEINARKIHGQ 989
               |..:||:.|.|||          ..:||  |....:..|:.|..||...:||.:::|.  ..
 Frog   825 ---LSSIIIVCGTLFV----------FWRELRDNLITPRDTTMTFTCFVFFDMFNALSSRS--QT 874

  Fly   990 RNVIE-GLLTNPIFYTIWIFTMISQVLIIQYGKM--AFSTKALTLDQWLWCIFFGIGTLVWGQLI 1051
            ::|.| ||.:|.:|....:.:::.|:|:|.:..:  .|.|::|::...::.|.......:..::|
 Frog   875 KSVFEIGLCSNKMFCYAVLGSIMGQLLVIYFPPLQKVFQTESLSIQDLVFLIGLTSSVCIVSEII 939

  Fly  1052 TSVPTRK 1058
            ..:...|
 Frog   940 KKLERSK 946

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	275/1044 (26%)
		Cation_ATPase_N	36..104	CDD:279080	11/47 (23%)
		E1-E2_ATPase	172..448	CDD:278548	70/291 (24%)
		Cation_ATPase	505..598	CDD:289987	27/103 (26%)
		HAD_like	676..807	CDD:119389	46/137 (34%)
		Cation_ATPase_C	873..1051	CDD:279079	46/182 (25%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
atp2c1	XP_002937789.2	P-type_ATPase_SPCA	98..940	CDD:319779	273/1038 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920