DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PMCA and atp2b1

DIOPT Version :9

Sequence 1:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster
Sequence 2:	XP_031753440.1	Gene:	atp2b1 / 100127567	XenbaseID:	XB-GENE-954671	Length:	1269	Species:	Xenopus tropicalis

Alignment Length:	1285	Identity:	743/1285 - (57%)
Similarity:	904/1285 - (70%)	Gaps:	138/1285 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QYGISLKQLRELMEHRGREGVMKIAEN-GGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVI 73
            ::||::::||.|||.|..:.:.||.|. |.::.:|.:|.|||:|||||:.||.|.|:|.||.|:|
Frog    23 EFGITIEELRTLMELRSTDALQKIQERYGDVYGICTRLKTSPHEGLSGNLADLERRQEAFGKNII 87

  Fly    74 PPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADED-------APVLQEEEEHHGWIE 131
            |||.|||||.|||||||||||||||:||::|||||||:|...|       :..::|||...||||
Frog    88 PPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYRPPGGDNELCGQASGAVEEEEGEAGWIE 152

  Fly   132 GLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVKY 196
            |.|||:||:.||:||||||:|||:||||||:|||.|.||:|:|||:|.||.|.||:||||||:||
Frog   153 GGAILVSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRGGQVIQIPVADIVVGDIAQIKY 217

  Fly   197 GDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVNSQAG 261
            ||||||||.|||.||||:||||||||||||||..:.||::|||||||||||||||||:|||||.|
Frog   218 GDLLPADGVLIQGNDLKIDESSLTGESDHVKKTLEKDPLLLSGTHVMEGSGKMVVTAIGVNSQTG 282

  Fly   262 IIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSESE 326
            ||||||||..:|:|.|.:|.||:.|  ||:::...||..:::.:...|...:...:.|....:.:
Frog   283 IIFTLLGAGENEEEKEKEKEKKDKK--NKKQDGAIENRNKAKAQDGAAMEMQPLKSEEGADGDDK 345

  Fly   327 GN-HLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEK 390
            .. :||            ||||||||.||||||:|||.||..::.:|||||::.|.|.||.:.::
Frog   346 KKANLP------------KKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVINTFWVQKR 398

  Fly   391 PW----KNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMG 451
            ||    ...|....||..||||||||||||||||||||:||||||||||||||||||||||||||
Frog   399 PWLAECTPIYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMG 463

  Fly   452 NATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISVNSAYTSNIMAGH 516
            ||||||||||||||.||||||||:|.||..:.:|....|.::|.:|:..|||||.||||.|:...
Frog   464 NATAICSDKTGTLTMNRMTVVQSFINEKHYRKVPDPDSISENVLDLLLTGISVNCAYTSKILPPE 528

  Fly   517 NPGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSMGTVIPRPNGGYR 581
            ..|.||..||||||||||||:..:...||.:|:||.|:...:|||||||||||.||:...:|.||
Frog   529 KEGGLPRHVGNKTECALLGFILDMKRDYQDVRNEIPEETLFKVYTFNSVRKSMSTVLKNADGSYR 593

  Fly   582 LYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISVAYRDFVPGKAAI 646
            :|:|||||||:|||....|..|..:.|....::.:::.||||||.:|||||.:|||||..|
Frog   594 MYSKGASEIILKKCFKTLGINGEAKIFRPRDRDDMVKRVIEPMASEGLRTICLAYRDFPAG---- 654

  Fly   647 NEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSI 711
                 :.||:|::|.:|:|.|||:.||||||||||||||||||||||||||||||||||||||:|
Frog   655 -----EHEPDWENENDILTGLTCIAVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARAI 714

  Fly   712 ASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDS 776
            |:|||||.|.:|||.:||||||||||:..|:|:|..|||:|||||||||||||||:|||||||||
Frog   715 ATKCGILHPGEDFLCVEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDS 779

  Fly   777 TVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNV 841
            ||.|.|:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   780 TVCEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNV 844

  Fly   842 YDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLL 906
            ||||:||||||||||||||||||.|||..|||||||||||||||||||.||||||||.||..|||
Frog   845 YDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLL 909

  Fly   907 RKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIESGRGQELNAGPTQHFTIIFNT 971
            ||||||.||||||||||||||.|:|||:::|.|||||:.:.||:|||...|:|.|:||:||:|||
Frog   910 RKPYGRNKPLISRTMMKNILGHAVYQLVVVFTLLFVGEKLFDIDSGRNAPLHAPPSQHYTIVFNT 974

  Fly   972 FVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAFSTKALTLDQWLW 1036
            ||||.||||||||||||:|||.||:..|.||.:|.:.|.|.|::|:|:|...||...||:|||||
Frog   975 FVMMQLFNEINARKIHGERNVFEGIFNNIIFCSIVLGTFIIQIVIVQFGGKPFSCTELTVDQWLW 1039

  Fly  1037 CIFFGIGTLVWGQLITSVPTRKLPKILSWGRGHPEEYTDGMNLGEERFDSID-SDKKPRAGQILW 1100
            .||.|:|||:||||:||:||.:|..:...|.|..::......|.|: .:.|| ::::.|.|||||
Frog  1040 SIFLGMGTLLWGQLVTSIPTSRLKFLKEAGHGTQKDEIPEEELAED-VEEIDHAERELRRGQILW 1103

  Fly  1101 IRGLTRLQTQ-----------------------------------------------------LR 1112
            .|||.|:|||                                                     :|
Frog  1104 FRGLNRIQTQMGWSFLLFSLSLAEQAVTISDSLQMDVVNAFQSGSSIQGALRRQPSIASQHHDIR 1168

  Fly  1113 VIRAFRSTL-EDLNERRSMHSLHSLRSPRTGIPVAVGGGHPLYNFNLLNPNYIKHQQQQEPKLPP 1176
            |:.||||:| |.|.:..|..|:|:..:            ||.:..           :..||.:|
Frog  1169 VVNAFRSSLYEGLEKPESRSSIHNFMT------------HPEFRI-----------EDSEPHIP- 1209

  Fly  1177 QTQLNVSSGMMSPDISYIDEDPQQQQRTLHNGLTSQRSSMPSNVPSSNQS 1226
                      :..|....|:.|            ::|.|.|...|:.|.:
Frog  1210 ----------LIDDTDAEDDAP------------TKRHSTPPPSPNKNNN 1237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	697/1059 (66%)
		Cation_ATPase_N	36..104	CDD:279080	45/68 (66%)
		E1-E2_ATPase	172..448	CDD:278548	169/280 (60%)
		Cation_ATPase	505..598	CDD:289987	54/92 (59%)
		HAD_like	676..807	CDD:119389	111/130 (85%)
		Cation_ATPase_C	873..1051	CDD:279079	124/177 (70%)
		ATP_Ca_trans_C	1096..1142	CDD:289209	24/99 (24%)
atp2b1	XP_031753440.1	ATPase-IIB_Ca	12..1060	CDD:273668	697/1059 (66%)
atp2b1	XP_031753440.1	ATP_Ca_trans_C	1099..1198	CDD:403580	25/110 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	259	1.000	Domainoid score	I1949
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1374	1.000	Inparanoid score	I132
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D115892at2759
OrthoFinder	1	1.000	-	-		FOG0000362
OrthoInspector	1	1.000	-	-		otm47598
Panther	1	1.100	-	-	O	PTHR24093
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X220
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080