Protein Alignment PMCA and atp2b1

DIOPT Version :10

• Sequence 1: NP_001014689.3
• Gene: PMCA / 43787
• FlyBaseID: FBgn0259214
• Length: 1255
• Species: Drosophila melanogaster
• Sequence 2: XP_031753440.1
• Gene: atp2b1 / 100127567
• XenbaseID: XB-GENE-954671
• Length: 1269
• Species: Xenopus tropicalis
• Alignment Length: 1285
• Identity: 743/1285 - (57%)
• Similarity: 904/1285 - (70%)
• Gaps: 138/1285 - (10%)

  Fly    10 QYGISLKQLRELMEHRGREGVMKIAEN-GGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVI 73
            ::||::::||.|||.|..:.:.||.|. |.::.:|.:|.|||:|||||:.||.|.|:|.||.|:|
 Frog    23 EFGITIEELRTLMELRSTDALQKIQERYGDVYGICTRLKTSPHEGLSGNLADLERRQEAFGKNII 87

  Fly    74 PPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADED-------APVLQEEEEHHGWIE 131
            |||.|||||.|||||||||||||||:||::|||||||:|...|       :..::|||...||||
 Frog    88 PPKKPKTFLQLVWEALQDVTLIILEIAAIISLGLSFYRPPGGDNELCGQASGAVEEEEGEAGWIE 152

  Fly   132 GLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVKY 196
            |.|||:||:.||:||||||:|||:||||||:|||.|.||:|:|||:|.||.|.||:||||||:||
 Frog   153 GGAILVSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVVRGGQVIQIPVADIVVGDIAQIKY 217

  Fly   197 GDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVNSQAG 261
            ||||||||.|||.||||:||||||||||||||..:.||::|||||||||||||||||:|||||.|
 Frog   218 GDLLPADGVLIQGNDLKIDESSLTGESDHVKKTLEKDPLLLSGTHVMEGSGKMVVTAIGVNSQTG 282

  Fly   262 IIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSESE 326
            ||||||||..:|:|.|.:|.||:.|  ||:::...||..:::.:...|...:...:.|....:.:
 Frog   283 IIFTLLGAGENEEEKEKEKEKKDKK--NKKQDGAIENRNKAKAQDGAAMEMQPLKSEEGADGDDK 345

  Fly   327 GN-HLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEK 390
            .. :||            ||||||||.||||||:|||.||..::.:|||||::.|.|.||.:.::
 Frog   346 KKANLP------------KKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVINTFWVQKR 398

  Fly   391 PW----KNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMG 451
            ||    ...|....||..||||||||||||||||||||:||||||||||||||||||||||||||
 Frog   399 PWLAECTPIYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMG 463

  Fly   452 NATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISVNSAYTSNIMAGH 516
            ||||||||||||||.||||||||:|.||..:.:|....|.::|.:|:..|||||.||||.|:...
 Frog   464 NATAICSDKTGTLTMNRMTVVQSFINEKHYRKVPDPDSISENVLDLLLTGISVNCAYTSKILPPE 528

  Fly   517 NPGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSMGTVIPRPNGGYR 581
            ..|.||..||||||||||||:..:...||.:|:||.|:...:|||||||||||.||:...:|.||
 Frog   529 KEGGLPRHVGNKTECALLGFILDMKRDYQDVRNEIPEETLFKVYTFNSVRKSMSTVLKNADGSYR 593

  Fly   582 LYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISVAYRDFVPGKAAI 646
            :|:|||||||:|||....|..|..:.|....::.:::.||||||.:|||||.:|||||..|
 Frog   594 MYSKGASEIILKKCFKTLGINGEAKIFRPRDRDDMVKRVIEPMASEGLRTICLAYRDFPAG---- 654

  Fly   647 NEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSI 711
                 :.||:|::|.:|:|.|||:.||||||||||||||||||||||||||||||||||||||:|
 Frog   655 -----EHEPDWENENDILTGLTCIAVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARAI 714

  Fly   712 ASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDS 776
            |:|||||.|.:|||.:||||||||||:..|:|:|..|||:|||||||||||||||:|||||||||
 Frog   715 ATKCGILHPGEDFLCVEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDS 779

  Fly   777 TVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNV 841
            ||.|.|:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   780 TVCEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNV 844

  Fly   842 YDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLL 906
            ||||:||||||||||||||||||.|||..|||||||||||||||||||.||||||||.||..|||
 Frog   845 YDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLL 909

  Fly   907 RKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIESGRGQELNAGPTQHFTIIFNT 971
            ||||||.||||||||||||||.|:|||:::|.|||||:.:.||:|||...|:|.|:||:||:|||
 Frog   910 RKPYGRNKPLISRTMMKNILGHAVYQLVVVFTLLFVGEKLFDIDSGRNAPLHAPPSQHYTIVFNT 974

  Fly   972 FVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAFSTKALTLDQWLW 1036
            ||||.||||||||||||:|||.||:..|.||.:|.:.|.|.|::|:|:|...||...||:|||||
 Frog   975 FVMMQLFNEINARKIHGERNVFEGIFNNIIFCSIVLGTFIIQIVIVQFGGKPFSCTELTVDQWLW 1039

  Fly  1037 CIFFGIGTLVWGQLITSVPTRKLPKILSWGRGHPEEYTDGMNLGEERFDSID-SDKKPRAGQILW 1100
            .||.|:|||:||||:||:||.:|..:...|.|..::......|.|: .:.|| ::::.|.|||||
 Frog  1040 SIFLGMGTLLWGQLVTSIPTSRLKFLKEAGHGTQKDEIPEEELAED-VEEIDHAERELRRGQILW 1103

  Fly  1101 IRGLTRLQTQ-----------------------------------------------------LR 1112
            .|||.|:|||                                                     :|
 Frog  1104 FRGLNRIQTQMGWSFLLFSLSLAEQAVTISDSLQMDVVNAFQSGSSIQGALRRQPSIASQHHDIR 1168

  Fly  1113 VIRAFRSTL-EDLNERRSMHSLHSLRSPRTGIPVAVGGGHPLYNFNLLNPNYIKHQQQQEPKLPP 1176
            |:.||||:| |.|.:..|..|:|:..:            ||.:..           :..||.:|
 Frog  1169 VVNAFRSSLYEGLEKPESRSSIHNFMT------------HPEFRI-----------EDSEPHIP- 1209

  Fly  1177 QTQLNVSSGMMSPDISYIDEDPQQQQRTLHNGLTSQRSSMPSNVPSSNQS 1226
                      :..|....|:.|            ::|.|.|...|:.|.:
 Frog  1210 ----------LIDDTDAEDDAP------------TKRHSTPPPSPNKNNN 1237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	P-type_ATPase_Ca_PMCA-like	62..921	CDD:319776	587/870 (67%)
		Cation_ATPase_C	873..1051	CDD:376368	124/177 (70%)
		ATP_Ca_trans_C	1096..1141	CDD:463575	24/98 (24%)
atp2b1	XP_031753440.1	ATPase-IIB_Ca	12..1060	CDD:273668	697/1059 (66%)
		ATP_Ca_trans_C	1099..1198	CDD:463575	25/110 (23%)