DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rad23 and UBI4

DIOPT Version :9

Sequence 1:	NP_001259052.1	Gene:	Rad23 / 43785	FlyBaseID:	FBgn0026777	Length:	414	Species:	Drosophila melanogaster
Sequence 2:	NP_013061.1	Gene:	UBI4 / 850620	SGDID:	S000003962	Length:	381	Species:	Saccharomyces cerevisiae

Alignment Length:	368	Identity:	79/368 - (21%)
Similarity:	143/368 - (38%)	Gaps:	85/368 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIITIKNLQQQTFTIEFAPEKTVLELKKKIFEERGPEYVAEKQKLIYAGVILTDDRTVGSYNVDE 65
            |.|.:|.|..:|.|:|.....|:..:|.||.::.|  ...::|:||:||..|.|.||:..||:.:
Yeast     1 MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEG--IPPDQQRLIFAGKQLEDGRTLSDYNIQK 63

  Fly    66 KKFIVVMLTRDSSSSNRNQLSVKESNKLTSTDDSKQSMPCEEANHTNSPSSTNTEDSVLSRETRP 130
            :..:.::|......    |:.||.....|.|.:.:           :|.:..|.:..:..:|..|
Yeast    64 ESTLHLVLRLRGGM----QIFVKTLTGKTITLEVE-----------SSDTIDNVKSKIQDKEGIP 113

  Fly   131 LSSDELI--GE-------LAQASLQSRAESNLLM----GDEY------NQTVLSMVEMGYPREQV 176
            .....||  |:       |:..::|..:..:|::    |.:.      .:|:...||.....:.|
Yeast   114 PDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNV 178

  Fly   177 ERAMAASYNNPERAVEYLINGIPAEEG---TFYNRLNESTNPSL--IPSGPQPASATSAERSTE- 235
            :..:......|......:..|...|:|   :.||...|||...:  :..|.|....|...::..
Yeast   179 KSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITL 243

  Fly   236 --SNSDPFEFLRSQPQFLQ-----MRSLIY----------------QNPHLLHAVLQ-----QI- 271
              .:||..:.::|:.|..:     .:.||:                |....||.||:     ||
Yeast   244 EVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIF 308

  Fly   272 -----GQTNPALLQLISENQDAFLNMLNQPIDRESESGATVPP 309
                 |:|    :.|..|:.|...|:.::..|:|.     :||
Yeast   309 VKTLTGKT----ITLEVESSDTIDNVKSKIQDKEG-----IPP 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rad23	NP_001259052.1	rad23	1..413	CDD:273167	79/368 (21%)
		RAD23_N	1..76	CDD:176400	24/74 (32%)
		UBA1_Rhp23p_like	153..199	CDD:270561	8/55 (15%)
		XPC-binding	242..296	CDD:286376	17/85 (20%)
		UBA2_HR23A	371..411	CDD:270610
UBI4	NP_013061.1	Ubl_ubiquitin	1..76	CDD:340501	24/76 (32%)
		Ubl_ubiquitin	77..152	CDD:340501	15/89 (17%)
		Ubl_ubiquitin	153..228	CDD:340501	13/74 (18%)
		Ubl_ubiquitin	229..304	CDD:340501	13/74 (18%)
		Ubl_ubiquitin	305..380	CDD:340501	12/47 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5272
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900