DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rad23 and isg15

DIOPT Version :9

Sequence 1:	NP_001259052.1	Gene:	Rad23 / 43785	FlyBaseID:	FBgn0026777	Length:	414	Species:	Drosophila melanogaster
Sequence 2:	NP_001191098.1	Gene:	isg15 / 558956	ZFINID:	ZDB-GENE-021211-1	Length:	157	Species:	Danio rerio

Alignment Length:	174	Identity:	44/174 - (25%)
Similarity:	73/174 - (41%)	Gaps:	29/174 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIITIKNLQQQTFTIEFAPEKTVLELKKKIFEE-RGPEYVAEKQKLIYAG---VILTDD-RTVGS 60
            |.:|:|.|......:|.:.:.||..||:.|.:. ..|.:   ||||....   :.|.|: ||:.|
Zfish     1 MQLTVKLLGGDVKRLEVSGDATVGILKQVISQYFNVPTF---KQKLSAENGQRISLEDESRTLSS 62

  Fly    61 YNVDEKKFIVVMLTRDSSSSNRNQLSVKESNKLTSTDDSKQSMPCEEANHTNSPSSTNTEDSVLS 125
            |.::....:::::|.:..:.   |:.||.......|.|       .:||.|.....|    .:..
Zfish    63 YGLNSDSVVMLLITTNPGTF---QVFVKNEKGQVKTYD-------VDANETVDQLQT----KIYQ 113

  Fly   126 RETRPLSSDELIGELAQASLQSRAESNLLMGDEYNQTVLSMVEM 169
            :|..|.....||.:..|      .||.:.:.| |:.|.||.:.|
Zfish   114 KERVPKDQQRLIFKGRQ------LESGMKLQD-YDITSLSTIHM 150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rad23	NP_001259052.1	rad23	1..413	CDD:273167	44/174 (25%)
		RAD23_N	1..76	CDD:176400	22/79 (28%)
		UBA1_Rhp23p_like	153..199	CDD:270561	6/17 (35%)
		XPC-binding	242..296	CDD:286376
		UBA2_HR23A	371..411	CDD:270610
isg15	NP_001191098.1	UBQ	1..76	CDD:214563	21/77 (27%)
		UBQ	3..75	CDD:294102	20/74 (27%)
		UBQ	82..153	CDD:214563	22/90 (24%)
		UBQ	83..157	CDD:294102	22/86 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5272
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900