DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rad23 and CG10694

DIOPT Version :9

Sequence 1:	NP_001259052.1	Gene:	Rad23 / 43785	FlyBaseID:	FBgn0026777	Length:	414	Species:	Drosophila melanogaster
Sequence 2:	NP_651212.1	Gene:	CG10694 / 42855	FlyBaseID:	FBgn0039147	Length:	290	Species:	Drosophila melanogaster

Alignment Length:	426	Identity:	113/426 - (26%)
Similarity:	179/426 - (42%)	Gaps:	150/426 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIITIKNLQQQTFTIEFAPEKTVLELKKKIFEERG--PEYV--AEKQKLIYAGVILTDDRTVGSY 61
            |.::|:.|.|:|.|:|....:.|..||:|:    |  ||..  ||..:|||:|.|:.|...:..|
  Fly     1 MKLSIRMLDQRTITLEMNESQEVRALKQKL----GNLPEVAMPAENLQLIYSGRIMEDAMPLSEY 61

  Fly    62 NVDEKKFIVVMLTRDSSSSNRNQLSVKESNKLTSTDDSKQSMPCEEANHT----NSPSSTNTEDS 122
            .:.|.|.||:|             ..|:.:|         |.|.|:...|    ..|:...|||.
  Fly    62 RIAEDKIIVLM-------------GKKKVDK---------SSPEEKVAPTPPLAAGPNVLRTEDV 104

  Fly   123 VLSRETRPLSSDELIGELAQASLQSRAESNLLMGDEYNQTVLSMVEMGYPREQVERAMAASYNNP 187
            |.|                           |...|::   |..::.|||..|:|..|:.||:|:|
  Fly   105 VPS---------------------------LAPNDQW---VSDLMSMGYGEEEVRSALRASFNHP 139

  Fly   188 ERAVEYLINGIP----AEEGTFYNRLNESTNPSLIPSGPQPASATSAERSTESNSDPFEFLRSQP 248
            |||:||||||||    :|:|.           :.|||              ...||..:.|.:..
  Fly   140 ERAIEYLINGIPQEVVSEQGL-----------AAIPS--------------VQTSDQLQQLMADL 179

  Fly   249 QFLQMRSLIYQNPHLLHAVLQQIGQTNPALLQLISENQDAFLNMLNQPIDRESESGATVPPVSNA 313
            ...:||.:|.|||.|:|.::.::.:|:||..::...||:..:||::        .||       :
  Fly   180 NITRMREMINQNPELIHRLMNRLAETDPATFEVFQRNQEELMNMIS--------GGA-------S 229

  Fly   314 RIPSTLDNVDLFSPDLEVATSAQRSAAGTSAAHQSGSAADNEDLEQPLGVSTIRLNRQDKDAIER 378
            |.|:.:::       |::..:|:.:|                                   |:.|
  Fly   230 RTPNEIEH-------LQITLTAEETA-----------------------------------AVGR 252

  Fly   379 LKALGFPEALVLQAYFACEKNEEQAANFLLSSSFDD 414
            |:||||...:.:|||.||:|:|:.||..|:..|.:|
  Fly   253 LEALGFERVMAVQAYLACDKDEQLAAEVLIRQSEED 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rad23	NP_001259052.1	rad23	1..413	CDD:273167	112/423 (26%)
		RAD23_N	1..76	CDD:176400	28/78 (36%)
		UBA1_Rhp23p_like	153..199	CDD:270561	22/45 (49%)
		XPC-binding	242..296	CDD:286376	16/53 (30%)
		UBA2_HR23A	371..411	CDD:270610	17/39 (44%)
CG10694	NP_651212.1	rad23	1..284	CDD:273167	111/420 (26%)
		UBQ	1..76	CDD:294102	28/91 (31%)
		UBA1_Rad23_like	110..148	CDD:270466	18/40 (45%)
		XPC-binding	172..227	CDD:286376	16/62 (26%)
		UBA2_Rad23_like	245..282	CDD:270467	17/71 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470124
Domainoid	1	1.000	40	1.000	Domainoid score	I4837
eggNOG	1	0.900	-	-		E1_COG5272
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53856
OrthoDB	1	1.010	-	-		D1260050at2759
OrthoFinder	1	1.000	-	-		FOG0001474
OrthoInspector	1	1.000	-	-		otm14359
orthoMCL	1	0.900	-	-		OOG6_101279
Panther	1	1.100	-	-	P	PTHR10621
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1097
SonicParanoid	0	0.000	Not matched by this tool.
	11	10.790