DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rad23 and rad23b

DIOPT Version :9

Sequence 1:	NP_001259052.1	Gene:	Rad23 / 43785	FlyBaseID:	FBgn0026777	Length:	414	Species:	Drosophila melanogaster
Sequence 2:	NP_956858.2	Gene:	rad23b / 393536	ZFINID:	ZDB-GENE-040426-1487	Length:	381	Species:	Danio rerio

Alignment Length:	440	Identity:	180/440 - (40%)
Similarity:	239/440 - (54%)	Gaps:	86/440 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIITIKNLQQQTFTIEFAPEKTVLELKKKIFEERGPE-YVAEKQKLIYAGVILTDDRTVGSYNVD 64
            |.||:|.||||||.|:...|:||..||:||..|:|.: :....|||||||.||:||..:..|.:|
Zfish     1 MQITLKTLQQQTFKIDIDAEETVKALKEKIENEKGKDGFPVAGQKLIYAGKILSDDTALKEYKID 65

  Fly    65 EKKFIVVMLTRDSSSSNRNQLSVKESNKLTSTDDSKQSMPCEEANHTNSPSSTNTEDSVLSRE-- 127
            ||.|:|||:|:..|:|.....| ..|:..:||..|..:.| ..|..:.|||.   |:...|.|
Zfish    66 EKNFVVVMVTKPKSASAPAPPS-SSSSSSSSTTASASAAP-SAAPVSESPSE---EEKKPSEEKP 125

  Fly   128 -------TRPLSSDELIGELAQASLQSRAESNLLMGDEYNQTVLSMVEMGYPREQVERAMAASYN 185
                   |.|:||    |.|..|::...|.|.|:.|..|...|..::.|||.|::|..|:.||:|
Zfish   126 SSDPAPATTPVSS----GSLPNANIFEEATSALVTGQSYENMVTEIMLMGYERDRVVAALRASFN 186

  Fly   186 NPERAVEYLINGIPAE-EGTFYNRLNESTNPSLIPSGPQPASATS---------------AERST 234
            ||:||||||:.||||| ||:....::     ::.|||..||||.:               |:.|:
Zfish   187 NPDRAVEYLLTGIPAEGEGSVVGAVD-----AVSPSGSTPASAPAPAISTGLSSPSSTAPAQPSS 246

  Fly   235 ESNSDPFEFLRSQPQFLQMRSLIYQNPHLLHAVLQQIGQTNPALLQLISENQDAFLNMLNQPIDR 299
            .|.::|.||||:||||||||.:|.|||.||.|:|||||:.||.|||.||.:|:.|:.|||:|:..
Zfish   247 ASGANPLEFLRNQPQFLQMRQIIQQNPSLLPALLQQIGRENPQLLQQISSHQEQFIQMLNEPVQE 311

  Fly   300 ESESGATVPPVSNARIPSTLDNVDLFSPDLEVATSAQRSAAGTSAAHQSGSAADNEDLEQPLGVS 364
            ..:.|                                    |.....::|....|
Zfish   312 AGQGG------------------------------------GAGGVAEAGGGHMN---------- 330

  Fly   365 TIRLNRQDKDAIERLKALGFPEALVLQAYFACEKNEEQAANFLLSSSFDD 414
            .|::..|:|:||||||||||||.||:||||||||||..||||||..:|||
Zfish   331 YIQVTPQEKEAIERLKALGFPEGLVIQAYFACEKNENLAANFLLQQNFDD 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rad23	NP_001259052.1	rad23	1..413	CDD:273167	177/437 (41%)
		RAD23_N	1..76	CDD:176400	40/75 (53%)
		UBA1_Rhp23p_like	153..199	CDD:270561	22/45 (49%)
		XPC-binding	242..296	CDD:286376	36/53 (68%)
		UBA2_HR23A	371..411	CDD:270610	32/39 (82%)
rad23b	NP_956858.2	rad23	1..379	CDD:273167	177/437 (41%)
		RAD23_N	1..78	CDD:176400	40/76 (53%)
		UBA1_Rad23	159..198	CDD:270560	19/38 (50%)
		XPC-binding	253..308	CDD:286376	36/54 (67%)
		UBA2_HR23B	337..381	CDD:270611	35/44 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595774
Domainoid	1	1.000	78	1.000	Domainoid score	I8700
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37704
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2962
OMA	1	1.010	-	-		QHG53856
OrthoDB	1	1.010	-	-		D1260050at2759
OrthoFinder	1	1.000	-	-		FOG0001474
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101279
Panther	1	1.100	-	-	O	PTHR10621
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1097
SonicParanoid	1	1.000	-	-		X1039
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.940