DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rad23 and UBL4B

DIOPT Version :9

Sequence 1:	NP_001259052.1	Gene:	Rad23 / 43785	FlyBaseID:	FBgn0026777	Length:	414	Species:	Drosophila melanogaster
Sequence 2:	NP_981957.1	Gene:	UBL4B / 164153	HGNCID:	32309	Length:	174	Species:	Homo sapiens

Alignment Length:	247	Identity:	50/247 - (20%)
Similarity:	91/247 - (36%)	Gaps:	82/247 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIITIKNLQQQTFTIEFAPEKTVLELKKKIFEE-RGPEYVAEKQKLIYAGVILTDDRTVGSYNVD 64
            |.:|:|.|..|..:::.:.:::|..||:.:... :.||   |:|.|::.|.:|.||:.:..|.:.
Human     1 MFLTVKLLLGQRCSLKVSGQESVATLKRLVSRRLKVPE---EQQHLLFRGQLLEDDKHLSDYCIG 62

  Fly    65 EKKFIVVMLTRDSSSSNRNQLSVKESNKLTSTDDSKQSMPCEEANHTNSPSSTNTEDSVLSRETR 129
            ....|.|::                        ...:.|..:||:...:....:....||::...
Human    63 PNASINVIM------------------------QPLEKMALKEAHQPQTQPLWHQLGLVLAKHFE 103

  Fly   130 PLSSDELIGELAQASLQSRAESNLLMGDEYNQTVLSMVEMGYPREQVERAMAASYNNPERAVEYL 194
            |        :.|:|.||      ||.                 :|..||....|..:.|:..:||
Human   104 P--------QDAKAVLQ------LLR-----------------QEHEERLQKISLEHLEQLAQYL 137

  Fly   195 INGIPAEEGTFYNRLNESTNPSLIPSG-------PQPASATSAERSTESNSD 239
            :    |||            |.:.|:|       .:|.|:...|...|:.:|
Human   138 L----AEE------------PHVEPAGERELEAKARPQSSCDMEEKEEAAAD 173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rad23	NP_001259052.1	rad23	1..413	CDD:273167	50/247 (20%)
		RAD23_N	1..76	CDD:176400	20/75 (27%)
		UBA1_Rhp23p_like	153..199	CDD:270561	9/45 (20%)
		XPC-binding	242..296	CDD:286376
		UBA2_HR23A	371..411	CDD:270610
UBL4B	NP_981957.1	UBQ	1..74	CDD:320785	20/99 (20%)
		FlhF	20..>154	CDD:332151	40/207 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..174		9/45 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5272
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900