DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rad23 and zfand4

DIOPT Version :9

Sequence 1:	NP_001259052.1	Gene:	Rad23 / 43785	FlyBaseID:	FBgn0026777	Length:	414	Species:	Drosophila melanogaster
Sequence 2:	NP_001189400.1	Gene:	zfand4 / 100148477	ZFINID:	ZDB-GENE-090312-102	Length:	673	Species:	Danio rerio

Alignment Length:	497	Identity:	97/497 - (19%)
Similarity:	160/497 - (32%)	Gaps:	185/497 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MIITIKNLQQQTFTIEFAPEKTVLELKKKIFEERGPEYVAEKQKLIYAGVILTDDRTVGSYNVDE 65
            |.:.|:.|....|.:..:|.:.|:.:|.||  :|.......:|.||:.|:.|.|:..:..|::.|
Zfish    28 MELFIETLTGTCFQLRVSPFEQVVSVKAKI--QRLEGIPVSQQHLIWNGMELEDEYCLHDYSITE 90

  Fly    66 KKFIVVMLTRDSSSSNRNQLSVKESNKLTSTDDS----------------KQSMP--------CE 106
            ...:.::|.......|        :.::|.||||                ::|:|        ..
Zfish    91 GCTLKLVLAMRGGPVN--------TRRVTVTDDSVRDISDCLDAGREEMWEKSLPNKQVTFLVYR 147

  Fly   107 EANHTNSPSSTNTEDSVLSRETRPLSSDELIGELAQASLQSRAESNLLMGDEYNQTVLSMVEMGY 171
            |.:..|.....:..|..|:..:..||...:....|:...:..:.|:.|      ||:.:.:.||
Zfish   148 EGDQLNFFRVVDRGDGTLTPVSESLSGASVRNVRAEEEEEQESASSEL------QTLENSITMG- 205

  Fly   172 PREQVERAMAASYN---NPERAVEYLINGIPAEEGTFYNRLNESTNPSLIPSGPQPASAT--SAE 231
             :.::.:|...:.|   .|::..:..|..                     |.||:|.|.:  ||.
Zfish   206 -KMKLLKAKMENMNLNKKPKKTAKLKIRP---------------------PVGPRPCSGSHGSAR 248

  Fly   232 RSTESNSDPFEFLRSQPQFLQMRSLIYQNPHLLHAVLQQIGQTNPALLQLISENQDAFLNMLNQP 296
            .                             |.:..||.|||..:...|..|.:.|        ||
Zfish   249 H-----------------------------HRMFRVLPQIGHASSTHLPPIGDQQ--------QP 276

  Fly   297 IDRESESGATVPPVSNARIPSTLDNVDLFSPDLEVATSAQRSAAGTSAAHQSGSAA--------- 352
            :       .:.|...:|..|.|    .|.||            |.:|.||.|.:|:
Zfish   277 V-------LSTPTAGSAHQPYT----SLSSP------------ASSSRAHPSSAASGIYMLQAEE 318

  Fly   353 --DNE--------------DLEQP----------------------LGVSTIRLNRQDK-DAIER 378
              ||.              |:..|                      :.:....|...:| ..||.
Zfish   319 PWDNPVPRKIRLPPKVSRLDMRGPKVMRDCVYPPLSLLSSPGVQDEVDIKNEHLTLTEKTTVIES 383

  Fly   379 LKALGF--PEALVLQAYFACEKN-------EEQAANFLLSSS 411
            .||:.|  ||.|.|......|::       |..||..|||.:
Zfish   384 PKAVPFNLPEPLSLDVSAQRERSLNSLTMPEANAAAPLLSQA 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rad23	NP_001259052.1	rad23	1..413	CDD:273167	97/497 (20%)
		RAD23_N	1..76	CDD:176400	19/74 (26%)
		UBA1_Rhp23p_like	153..199	CDD:270561	9/48 (19%)
		XPC-binding	242..296	CDD:286376	9/53 (17%)
		UBA2_HR23A	371..411	CDD:270610	17/49 (35%)
zfand4	NP_001189400.1	AN1_N	1..103	CDD:176397	19/76 (25%)
		UBQ	28..99	CDD:214563	18/72 (25%)
		ZnF_AN1	613..651	CDD:197545
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5272
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900