DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt7 and SYTL3

DIOPT Version :9

Sequence 1:	NP_726557.3	Gene:	Syt7 / 43783	FlyBaseID:	FBgn0039900	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001229313.1	Gene:	SYTL3 / 94120	HGNCID:	15587	Length:	610	Species:	Homo sapiens

Alignment Length:	536	Identity:	121/536 - (22%)
Similarity:	206/536 - (38%)	Gaps:	143/536 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CLAILGLII---------------TIALFLAGGYLW-----------------WRHKRSQLQFIE 41
            |..:||.::               ...:||.|.:.|                 |.::....:|..
Human    66 CQQVLGFLLHRGAVCRGCSHRVCAQCRVFLRGTHAWKCTVCFEDRNVKIKTGEWFYEERAKKFPT 130

  Fly    42 PNEDEESSSYSLRAAQDIVD-SGNPPTKPQVPVAHAITTP--LQ-----NNINRKL-NGFLSLRT 97
            ..:.|......|::.|.:.. |..|||.|.|..:....:|  ||     ...|:.: |.||||.|
Human   131 GGKHETVGGQLLQSYQKLSKISVVPPTPPPVSESQCSRSPGRLQEFGQFRGFNKSVENLFLSLAT 195

  Fly    98 PL--IGGSGASQTKPQII------SSVGNPGDGTTKDSA----NKSISMTDMY------------ 138
            .:  :..|....|..:.:      ..||.....:..|:|    .:.:|..|:.
Human   196 HVKKLSKSQNDMTSEKHLLATGPRQCVGQTERRSQSDTAVNVTTRKVSAPDILKPLNQEDPKCST 260

  Fly   139 ------------------------------LDST-------DPSENVGQIHFSLEYDFQNTTLIL 166
                                          :|||       |.:...|:|.|::.|.|:..:|.:
Human   261 NPILKQQNLPSSPAPSTIFSGGFRHGSLISIDSTCTEMGNFDNANVTGEIEFAIHYCFKTHSLEI 325

  Fly   167 KVLQGKELP-AKDLSGTSDPYVRVTLLPDK--KHRLETKIKRRTLNPRWNETFYFEGFPIQKLQS 228
            .:...|.|. .::.....:|||:..||||:  :.:.:|.::|.|::|.:.||..::..|.| |.:
Human   326 CIKACKNLAYGEEKKKKCNPYVKTYLLPDRSSQGKRKTGVQRNTVDPTFQETLKYQVAPAQ-LVT 389

  Fly   229 RVLHLHVFDYDRFSRDDSIGEVFLPLCQVDF--AGKQSF-WKALKPPAK-------DKCGEL-LS 282
            |.|.:.|:.....:|...:|||.:||...||  :..||| |..|:..|:       ...||| :.
Human   390 RQLQVSVWHLGTLARRVFLGEVIIPLATWDFEDSTTQSFRWHPLRAKAEKYEDSVPQSNGELTVR 454

  Fly   283 SLCYHPS-----------------NSILTLTLIKARNLKAKDINGKSDPYVKVWLQFGDKRVEKR 330
            :....||                 :..|.|.::.|:||..:. :|..:.:||..|...|::..:.
Human   455 AKLVLPSRPRKLQEAQEGTDQPSLHGQLCLVVLGAKNLPVRP-DGTLNSFVKGCLTLPDQQKLRL 518

  Fly   331 KTPIFTCTLNPVFNESFSFN-VPWEKIRECSLDVMVMDFDNIGRNE-LIGRILLAGK-----NGS 388
            |:|:......|.:..||.|: |...::|:.||::.|.|....|.|: |:|...|..|     .|.
Human   519 KSPVLRKQACPQWKHSFVFSGVTPAQLRQSSLELTVWDQALFGMNDRLLGGTRLGSKGDTAVGGD 583

  Fly   389 GASETK-HWQDMISKP 403
            ..|.:| .||.::|.|
Human   584 ACSLSKLQWQKVLSSP 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt7	NP_726557.3	C2A_Synaptotagmin-7	147..271	CDD:176032	40/129 (31%)
Syt7	NP_726557.3	C2B_Synaptotagmin-7	277..414	CDD:176050	40/153 (26%)
SYTL3	NP_001229313.1	PHD_SF	8..123	CDD:328929	8/56 (14%)
		FYVE_Slp3	60..108	CDD:277304	7/41 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..239		4/19 (21%)
		C2A_SLP-3	307..434	CDD:176038	39/127 (31%)
		C2B_SLP_1-2-3-4	448..610	CDD:175987	40/153 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910