DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt7 and DOC2B

DIOPT Version :9

Sequence 1:	NP_726557.3	Gene:	Syt7 / 43783	FlyBaseID:	FBgn0039900	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_003576.2	Gene:	DOC2B / 8447	HGNCID:	2986	Length:	412	Species:	Homo sapiens

Alignment Length:	382	Identity:	117/382 - (30%)
Similarity:	170/382 - (44%)	Gaps:	62/382 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 PPTKPQVP-VAHAITTPLQNNINRKLNGFLSLRTPLIGGSGASQTKPQIISSVG-----NPGDGT 123
            ||..|..| ||.|                 ..|:|..|.....:...|:..:.|     :||...
Human    55 PPDAPARPAVAGA-----------------GRRSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSP 102

  Fly   124 TKDSANKSISMTDMYLDSTDPSENVGQIHFSLEYDFQNTTLILKVLQGKELPAKDLSGTSDPYVR 188
            .:..|.......|.....:|....:|.:.|||.||.:|..|...:.:.|.|...|.:|.:||||:
Human   103 ARPPAKPPEDEPDADGYESDDCTALGTLDFSLLYDQENNALHCTITKAKGLKPMDHNGLADPYVK 167

  Fly   189 VTLLP--DKKHRLETKIKRRTLNPRWNETFYFEGFPIQKLQSRVLHLHVFDYDRFSRDDSIGEVF 251
            :.|||  .|.::|.||..|.||||.||||..:.|...:.:..:.|.:.|.|.|:|..::.|||..
Human   168 LHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETR 232

  Fly   252 LPLCQVDFAGKQSFWKALKP-----------------PAKDKC----GELLSSLCYHPSNSILTL 295
            :||            |.|||                 ..:||.    |.:|.||.|......|.:
Human   233 VPL------------KKLKPNHTKTFSICLEKQLPVDKTEDKSLEERGRILISLKYSSQKQGLLV 285

  Fly   296 TLIKARNLKAKDINGKSDPYVKVWLQFGDKRVEKRKTPIFTCTLNPVFNESFSFNVPWEKIRECS 360
            .:::..:|.|.|.||.||||||.:|:....:..|.||.:...||||.|||.|.:.:....:.:.|
Human   286 GIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFNEEFCYEIKHGDLAKKS 350

  Fly   361 LDVMVMDFDNIGR-NELIGRILLAGKNGSGASETKHWQDMISKPRQTVVQWHRLKPE 416
            |:|.|.|:| ||: |:.||.::| |.:..| ...|||.|.:....:.:.:||.|..|
Human   351 LEVTVWDYD-IGKSNDFIGGVVL-GIHAKG-ERLKHWFDCLKNKDKRIERWHTLTSE 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt7	NP_726557.3	C2A_Synaptotagmin-7	147..271	CDD:176032	45/125 (36%)
Syt7	NP_726557.3	C2B_Synaptotagmin-7	277..414	CDD:176050	49/141 (35%)
DOC2B	NP_003576.2	Mediates interaction with DYNLT1. /evidence=ECO:0000269\|PubMed:9804756	1..90		11/51 (22%)
		Negatively regulates targeting to plasma membrane. /evidence=ECO:0000250	1..36
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..123		16/84 (19%)
		C2A_Rabphilin_Doc2	127..250	CDD:176000	47/134 (35%)
		Mediates interaction with STXBP3. /evidence=ECO:0000250	257..375		44/119 (37%)
		C2B_Rabphilin_Doc2	269..401	CDD:176030	48/134 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910