DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt7 and SYT16

DIOPT Version :9

Sequence 1:	NP_726557.3	Gene:	Syt7 / 43783	FlyBaseID:	FBgn0039900	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001354585.1	Gene:	SYT16 / 83851	HGNCID:	23142	Length:	645	Species:	Homo sapiens

Alignment Length:	406	Identity:	96/406 - (23%)
Similarity:	166/406 - (40%)	Gaps:	59/406 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 ESSSYSLRAAQDIVDSGNPPTKPQVP----------VAHAITTPLQNNINRKLNGFLSLRTPLIG 101
            |:.||.        :..:.|...|.|          .:|..::.:|:...:...|.|.:.| ...
Human   257 ENLSYG--------EDDHIPAHSQSPCERGDAKHHGTSHQESSVVQSLRRQSTEGSLEMET-AFN 312

  Fly   102 GSGASQTKPQIISSVGNPGDGTTKDSANKSISMTDMYLDSTDPSENVGQIHFSLEYDFQNTTLIL 166
            ..|...:.....||:.:|.:   :|..|..:..     ..::|....|.:....||...:..|.:
Human   313 SRGFEDSYATDSSSMWSPEE---QDRTNLQVPS-----GVSEPISKCGDLDVIFEYRAASQKLTV 369

  Fly   167 KVLQGKELPAKDLSGTSDPYVRVTLLPDKKHRLETKIKRRTLNPRWNETFYFEGFPIQKLQSRVL 231
            .:::.:.||.||.||.:...|.|.|||.||||..|.|:|.. ||.:.|...|.....:.:.:..:
Human   370 TIVRAQGLPDKDRSGVNSWQVHVVLLPGKKHRGRTNIQRGP-NPVFREKVTFAKLEPRDVAACAV 433

  Fly   232 HLHVFDYDRFSRDDSIGEVFLPLCQVDFAGKQSFWKALKPPAKDKCG------------------ 278
            ...::...:.:|:..:||....|..:...|:......|:|.:....|
Human   434 RFRLYAARKMTRERMMGEKLFYLSHLHPEGEMKVTLVLEPRSNISSGGSPLSPSAVSHSDSTSST 498

  Fly   279 ---------ELLSSLCYHPSNSILTLTLIKARNLKAKDINGKSDPYVKVWL--QFGDKRVEKRKT 332
                     |||..|.|:.:...|::.:||..:.:...:|...|.|.|::|  ..| :.:.:.||
Human   499 QSLSHGGAPELLVGLSYNATTGRLSVEMIKGSHFRNLAVNRAPDTYGKLFLLNSVG-QEMSRCKT 562

  Fly   333 PIFTCTLNPVFNESFSFNVPWEKIRECSLDVMVMDFDNIGRNELIGRILLAGKNGSGASETKHWQ 397
            .|.....|||:.|:|.|.|...::.:.:|.:.|.:...:.|.|:||.|.| |:|.||..|..||:
Human   563 SIRRGQPNPVYKETFVFQVALFQLSDVTLMISVYNRRTMKRKEMIGWIAL-GQNSSGEEEQDHWE 626

  Fly   398 DMISKPRQTVVQWHRL 413
            :|.....|.:.:||.|
Human   627 EMKETKGQQICRWHTL 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt7	NP_726557.3	C2A_Synaptotagmin-7	147..271	CDD:176032	32/123 (26%)
Syt7	NP_726557.3	C2B_Synaptotagmin-7	277..414	CDD:176050	45/166 (27%)
SYT16	NP_001354585.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	102..121
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..192
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..344		17/103 (17%)
		C2A_Synaptotagmin-14_16	350..473	CDD:176035	32/123 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..503		1/24 (4%)
		C2B_Synaptotagmin-14_16	506..643	CDD:176053	44/139 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910