DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt7 and syt9a

DIOPT Version :9

Sequence 1:	NP_726557.3	Gene:	Syt7 / 43783	FlyBaseID:	FBgn0039900	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	XP_001336058.4	Gene:	syt9a / 798433	ZFINID:	ZDB-GENE-031002-18	Length:	547	Species:	Danio rerio

Alignment Length:	497	Identity:	169/497 - (34%)
Similarity:	248/497 - (49%)	Gaps:	112/497 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASIVLIAC-LAILGLIITIALFLAGGYLW--WRHK---------------------RSQLQFIE 41
            :.|:|:.|| ||:.|    ::||::....|  ||.:                     :.|..:.|
Zfish    55 LLSLVVTACGLALFG----VSLFVSWKLCWIPWRERGLSPGTKEGHPDPPHPPPPPLQPQPIYTE 115

  Fly    42 PNE--DEESSSYSLRAAQDIVD--------SGNPP-------------TKPQVPV---------- 73
            .:.  |..|::.|....:..|.        .|:||             |.|.:|:
Zfish   116 VDATLDRRSNARSSVVKETTVPPTPVSPAVPGSPPAVPVPEAALKISHTSPDIPLEVESKTQENG 180

  Fly    74 AHA-------ITTP-----LQNNINRKLN----GFLSL---RTPLIGGSGASQTKPQIISSVGNP 119
            .|.       ||.|     .|::|.|::|    .|...   |...:.|....|.||::.......
Zfish   181 VHGNTRMQRQITDPSSTCVRQSSIRRQMNQSNPDFTVTQFQRQDSLTGMSLGQLKPELYKQRSLD 245

  Fly   120 GDGTTKDSANKSISMTDMYLDSTDPSENVGQIHFSLEYDFQNTTLILKVLQGKELPAKDLSGTSD 184
            |:    ||.:..:.             :.|::||.|:||.....||:|:.:.::|||||.|||||
Zfish   246 GE----DSRSSRVG-------------SCGRLHFILKYDCDLEQLIVKIHRAQDLPAKDFSGTSD 293

  Fly   185 PYVRVTLLPDKKHRLETKIKRRTLNPRWNETFYFEGFPI--QKLQSRVLHLHVFDYDRFSRDDSI 247
            |||::.||||:|.:.:||:.|:||||.::|.|.   ||:  ..|.:|.||..|:|:|||||.|.|
Zfish   294 PYVKIYLLPDRKTKHQTKVHRKTLNPVFDEVFL---FPVAYADLPTRKLHFSVYDFDRFSRHDII 355

  Fly   248 GEV----FLPLCQVDFAGKQSFWKALKPPAKDK--CGELLSSLCYHPSNSILTLTLIKARNLKAK 306
            |:|    ||.|  |||..:....:.::..:.|.  .|:|:.||||.|:...||:|:||||||||.
Zfish   356 GQVVVDNFLDL--VDFPRETKLCRDIQYVSSDNVDLGDLMFSLCYLPTAGRLTITMIKARNLKAM 418

  Fly   307 DINGKSDPYVKVWLQFGDKRVEKRKTPIFTCTLNPVFNESFSFNVPWEKIRECSLDVMVMDFDNI 371
            ||.|.|||||||.|....:|::||||.....|||||:||:..|:||.|.|.:.||.|.|||:|.:
Zfish   419 DITGASDPYVKVSLMCDGRRLKKRKTSTKRNTLNPVYNEAIVFDVPPENIDQISLLVAVMDYDRV 483

  Fly   372 GRNELIGRILLAGKNGSGASETKHWQDMISKPRQTVVQWHRL 413
            |.||:|| :...|.:..|... :||.:|::.||:.:..||.|
Zfish   484 GHNEVIG-VCRVGNDAEGLGR-EHWNEMLTYPRKPIAHWHPL 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt7	NP_726557.3	C2A_Synaptotagmin-7	147..271	CDD:176032	59/129 (46%)
Syt7	NP_726557.3	C2B_Synaptotagmin-7	277..414	CDD:176050	68/137 (50%)
syt9a	XP_001336058.4	C2	257..381	CDD:301316	59/128 (46%)
syt9a	XP_001336058.4	C2B_Synaptotagmin-3-5-6-9-10	390..523	CDD:176048	67/134 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920