DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt7 and SYT1

DIOPT Version :9

Sequence 1:	NP_726557.3	Gene:	Syt7 / 43783	FlyBaseID:	FBgn0039900	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001129277.1	Gene:	SYT1 / 6857	HGNCID:	11509	Length:	422	Species:	Homo sapiens

Alignment Length:	325	Identity:	141/325 - (43%)
Similarity:	206/325 - (63%)	Gaps:	19/325 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 GGSGASQTKPQIISSVGNPGDGTTKDSANK----SISMTDMYLDSTDP--SENVGQIHFSLEYDF 159
            ||..|...|.  :..:|.    |.||.|.|    ...:||.. :..:|  .|.:|::.:||:|||
Human    97 GGKNAINMKD--VKDLGK----TMKDQALKDDDAETGLTDGE-EKEEPKEEEKLGKLQYSLDYDF 154

  Fly   160 QNTTLILKVLQGKELPAKDLSGTSDPYVRVTLLPDKKHRLETKIKRRTLNPRWNETFYFEGFPIQ 224
            ||..|::.::|..||||.|:.|||||||:|.||||||.:.|||:.|:||||.:||.|.|: .|..
Human   155 QNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFK-VPYS 218

  Fly   225 KLQSRVLHLHVFDYDRFSRDDSIGEVFLPLCQVDFAGKQSFWKALKPPAK---DKCGELLSSLCY 286
            :|..:.|.:.|:|:||||:.|.|||..:|:..|||......|:.|:...|   :|.|::..||.|
Human   219 ELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRY 283

  Fly   287 HPSNSILTLTLIKARNLKAKDINGKSDPYVKVWLQFGDKRVEKRKTPIFTCTLNPVFNESFSFNV 351
            .|:...||:.:::|:|||..|:.|.||||||:.|....||::|:||.|...||||.:||||||.|
Human   284 VPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEV 348

  Fly   352 PWEKIRECSLDVMVMDFDNIGRNELIGRILLAGKNGSGASETKHWQDMISKPRQTVVQWHRLKPE 416
            |:|:|::..:.|.|:|:|.||:|:.||::.: |.|.:|| |.:||.||::.||:.:.|||.|:.|
Human   349 PFEQIQKVQVVVTVLDYDKIGKNDAIGKVFV-GYNSTGA-ELRHWSDMLANPRRPIAQWHTLQVE 411

Fly 417 416
Human 412 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt7	NP_726557.3	C2A_Synaptotagmin-7	147..271	CDD:176032	60/123 (49%)
Syt7	NP_726557.3	C2B_Synaptotagmin-7	277..414	CDD:176050	63/136 (46%)
SYT1	NP_001129277.1	Syt1_N	6..113	CDD:409248	5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..142		8/29 (28%)
		Phospholipid binding. /evidence=ECO:0000305	136..382		114/247 (46%)
		C2A_Synaptotagmin-1-5-6-9-10	143..265	CDD:176031	60/122 (49%)
		C2B_Synaptotagmin-1	274..409	CDD:176047	63/136 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920