DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt7 and Syt9

DIOPT Version :9

Sequence 1:	NP_726557.3	Gene:	Syt7 / 43783	FlyBaseID:	FBgn0039900	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	XP_038944965.1	Gene:	Syt9 / 60564	RGDID:	621169	Length:	566	Species:	Rattus norvegicus

Alignment Length:	481	Identity:	167/481 - (34%)
Similarity:	239/481 - (49%)	Gaps:	115/481 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASIVLIAC-LAILGLIITIALFLAGGYLW--WRHK----------RSQLQFIEPNEDEESSSYS 52
            :.::|:.|| ||:.|    ::||::....|  ||.:          :..|.:.:...:|:.:|
  Rat    54 LLTLVVTACGLALFG----VSLFVSWKLCWVPWRERGLFSGSKDNNQEPLNYTDTETNEQENS-- 112

  Fly    53 LRAAQDIVDSGNP---------PTKPQVPV----------AHAITTPLQ----------NNINRK 88
                :|.:|...|         .|.|.:|:          |||:....|          |:|.|:
  Rat   113 ----EDFLDPPTPCPDSSMKISHTSPDIPLSTQPGGQDNCAHAVRVQRQVTEPTPSARHNSIRRQ 173

  Fly    89 LNGFLSLRTPLIGGSGASQTKPQIISSVGNP--------------GDGTTKDSANKSISMTDMYL 139
            ||                         :.||              |.|..|....|..|     |
  Rat   174 LN-------------------------LSNPDFNIQQLQRQEQLTGIGRIKPELYKQRS-----L 208

  Fly   140 DSTD----PSENVGQIHFSLEYDFQNTTLILKVLQGKELPAKDLSGTSDPYVRVTLLPDKKHRLE 200
            |:.|    .|:..|:::|.|:||.....||:|:.:...|||||.||||||||::.||||:|.:.:
  Rat   209 DNDDGRRSNSKACGKLNFILKYDCDLEQLIVKIHKAVNLPAKDFSGTSDPYVKIYLLPDRKTKHQ 273

  Fly   201 TKIKRRTLNPRWNETFYFEGFPI--QKLQSRVLHLHVFDYDRFSRDDSIGEV----FLPLCQVDF 259
            ||:.|:||||.::|.|.   ||:  ..|::|.||..|:|:|||||.|.||:|    |..|  .||
  Rat   274 TKVHRKTLNPVFDEVFL---FPVHYNDLEARKLHFSVYDFDRFSRHDLIGQVVVDHFFDL--ADF 333

  Fly   260 AGKQSFWKALKPPAKDK--CGELLSSLCYHPSNSILTLTLIKARNLKAKDINGKSDPYVKVWLQF 322
            ..:...||.::....|.  .|||:.||||.|:...||:|:||||||||.||.|.|||||||.|..
  Rat   334 PRECILWKDIEYVTNDNVDLGELMFSLCYLPTAGRLTITIIKARNLKAMDITGASDPYVKVSLMC 398

  Fly   323 GDKRVEKRKTPIFTCTLNPVFNESFSFNVPWEKIRECSLDVMVMDFDNIGRNELIGRILLAGKNG 387
            ..:|::||||.....|||||:||:..|:||.|.|.:..|.:.|||:|.:|.||:|| :...| |.
  Rat   399 DGRRLKKRKTSTKRNTLNPVYNEAIVFDVPPESIDQIHLSIAVMDYDRVGHNEVIG-VCQVG-NE 461

  Fly   388 SGASETKHWQDMISKPRQTVVQWHRL 413
            :......||.:|:|.||:.:..||.|
  Rat   462 AERLGRDHWSEMLSYPRKPIAHWHSL 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt7	NP_726557.3	C2A_Synaptotagmin-7	147..271	CDD:176032	58/129 (45%)
Syt7	NP_726557.3	C2B_Synaptotagmin-7	277..414	CDD:176050	68/137 (50%)
Syt9	XP_038944965.1	C2	221..345	CDD:417471	58/128 (45%)
Syt9	XP_038944965.1	C2B_Synaptotagmin-3-5-6-9-10	354..487	CDD:176048	67/134 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920