DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt7 and syt7a

DIOPT Version :9

Sequence 1:	NP_726557.3	Gene:	Syt7 / 43783	FlyBaseID:	FBgn0039900	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	XP_021326273.1	Gene:	syt7a / 561429	ZFINID:	ZDB-GENE-090601-5	Length:	653	Species:	Danio rerio

Alignment Length:	376	Identity:	183/376 - (48%)
Similarity:	236/376 - (62%)	Gaps:	46/376 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 AAQDIVDSGNPPTKPQVPVAHAITTPLQNNINRKLNGFLSLRTPLIGGSGASQTKPQIISSVGNP 119
            |.||  |..|.|...:||.:.......:|..|:..|                       |..|.|
Zfish   307 AEQD--DFANLPDLQEVPASQETPEKSRNMGNKPAN-----------------------SPKGQP 346

  Fly   120 ----GDGTTKDSANKSISMT-DMYL--------DSTDP-SENVGQIHFSLEYDFQNTTLILKVLQ 170
                |..:..|.||   |:| ||.:        |...| ||.:|:|.|||.|.||:|||.:|:|:
Zfish   347 PDADGHSSVSDLAN---SLTGDMVMLSPGSEDDDHEGPVSEKLGRIQFSLGYSFQDTTLTVKILK 408

  Fly   171 GKELPAKDLSGTSDPYVRVTLLPDKKHRLETKIKRRTLNPRWNETFYFEGFPIQKLQSRVLHLHV 235
            |::|||||.||||||:|::.||||:||:||||:||:.|||.|||||.|||||.:|::.|.|:|.|
Zfish   409 GQDLPAKDFSGTSDPFVKIYLLPDRKHKLETKVKRKNLNPHWNETFLFEGFPYEKVRERTLYLQV 473

  Fly   236 FDYDRFSRDDSIGEVFLPLCQVDFAGKQSFWKALKP--PAKDKCGELLSSLCYHPSNSILTLTLI 298
            .|||||||:|.||||.:||.:|:....:||||.|||  ......|:||.||||:|:.:.:|:.:|
Zfish   474 LDYDRFSRNDPIGEVSIPLNKVELGQLKSFWKDLKPCSDGSGSRGDLLVSLCYNPTANTITVNII 538

  Fly   299 KARNLKAKDINGKSDPYVKVWLQFGDKRVEKRKTPIFTCTLNPVFNESFSFNVPWEKIRECSLDV 363
            |||||||.||.|.|||||||||...||||||:||......|||||||||.|:||...:||.::.:
Zfish   539 KARNLKAMDIGGTSDPYVKVWLMHKDKRVEKKKTVTIKRCLNPVFNESFPFDVPAHVLRETTIII 603

  Fly   364 MVMDFDNIGRNELIGRILLAGKNGSGASETKHWQDMISKPRQTVVQWHRLK 414
            .|||.|.:.||::||:|.|:.|:|.|  |.|||:||:|:||..|.|||.||
Zfish   604 TVMDKDRLSRNDVIGKIYLSWKSGPG--EVKHWKDMLSRPRTNVAQWHALK 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt7	NP_726557.3	C2A_Synaptotagmin-7	147..271	CDD:176032	76/123 (62%)
Syt7	NP_726557.3	C2B_Synaptotagmin-7	277..414	CDD:176050	77/136 (57%)
syt7a	XP_021326273.1	C2A_Synaptotagmin-7	385..509	CDD:176032	76/123 (62%)
syt7a	XP_021326273.1	C2B_Synaptotagmin-7	517..652	CDD:176050	77/136 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592541
Domainoid	1	1.000	149	1.000	Domainoid score	I4381
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	331	1.000	Inparanoid score	I2420
OMA	1	1.010	-	-		QHG48323
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		otm25902
orthoMCL	1	0.900	-	-		OOG6_105953
Panther	1	1.100	-	-	LDO	PTHR10024
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5064
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.940