DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt7 and sytl1

DIOPT Version :9

Sequence 1:	NP_726557.3	Gene:	Syt7 / 43783	FlyBaseID:	FBgn0039900	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001006773.1	Gene:	sytl1 / 448459	XenbaseID:	XB-GENE-972182	Length:	518	Species:	Xenopus tropicalis

Alignment Length:	416	Identity:	113/416 - (27%)
Similarity:	186/416 - (44%)	Gaps:	67/416 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EPNEDEE-----------SSSYSL--RAAQDIVDSGNPPTKPQVPVAHAITTPLQNNINRKLNGF 92
            :.||:.|           |||.||  |.:.|..|..:  :|..|   ...||..:|:: ..:|
Frog   108 DENEEREGPEETCAPVKISSSESLPDRLSSDAQDWSS--SKEDV---GGDTTDGKNSM-EDIN-- 164

  Fly    93 LSLRTPLIGGSGASQTKPQIISSVGNPGDG-TTKDSANKSISMTDMYLDSTDPSENV---GQIHF 153
               .:|:.|...:..|..:|:....|..|. ......|.|||.:.:.|.||....:|   |.:.|
Frog   165 ---LSPVNGTITSGDTNGEILEGKENLNDSPPVPRLTNNSISGSMISLFSTGDMRSVDVQGCVQF 226

  Fly   154 SLEYDFQNTTLILKVLQGKEL-PAKDLSGTSDPYVRVTLLPDK--KHRLETKIKRRTLNPRWNET 215
            ||:||.....|.:.::|.::| ||:  ..||:||::..|||||  :.:.::|:|::||.|.:|||
Frog   227 SLQYDPSKKELNVLIIQCRDLTPAQ--RKTSNPYIKCYLLPDKTVQGKRKSKVKKKTLEPFFNET 289

  Fly   216 FYFEGFPIQKLQSRVLHLHVFDYDRFSRDDSIGEVFLPLCQVDFAGKQSFWKALKP--PAKDK-- 276
            ..:: ....:||||||:|.|:......|:..:|||.:.|...|::..|..|..|:|  |....
Frog   290 LKYK-VERSELQSRVLNLSVWHRGSLGRNIFLGEVEVDLVSWDWSKTQPSWFNLQPRTPLSPDFL 353

  Fly   277 C--GELLSSLCYHPSNS---------ILTLTLIKARNL---KAKDINGKSDPYVKVWLQFGDKRV 327
            |  |.:..:|.|.|..:         .|.:.:.:||.|   ||    |....:||.::.......
Frog   354 CSRGRISVALKYVPQGAEGLGLPPTGELHVWIKEARQLVPHKA----GNVSTFVKCFVLPDSVPS 414

  Fly   328 EKRKTPIFTCTLNPVFNESFSFN-VPWEKIRECSLDVMVMDFDNIGRNELIGRILLAGKNG---- 387
            ..:.|.:...:|:|:||.:..:: ...|.::|..::..:.|...||...|.|..|..||..
Frog   415 NFQNTRVIPHSLHPMFNHTMVYDGFSGEDLKEACVECTIWDQGKIGSRSLGGIRLSTGKGSSYET 479

  Fly   388 ------SGASETKHWQDMISKPRQTV 407
                  |...|...|:.:|:.|.:.|
Frog   480 SVSWMDSTVEEKAFWESVINNPGEWV 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt7	NP_726557.3	C2A_Synaptotagmin-7	147..271	CDD:176032	46/129 (36%)
Syt7	NP_726557.3	C2B_Synaptotagmin-7	277..414	CDD:176050	35/156 (22%)
sytl1	NP_001006773.1	PHD_SF	20..>66	CDD:419867
		C2	221..343	CDD:417471	44/124 (35%)
		C2B_SLP_1-2-3-4	356..512	CDD:175987	34/154 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910