DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt7 and Syt1

DIOPT Version :9

Sequence 1:	NP_726557.3	Gene:	Syt7 / 43783	FlyBaseID:	FBgn0039900	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster

Alignment Length:	323	Identity:	137/323 - (42%)
Similarity:	204/323 - (63%)	Gaps:	22/323 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 LIGGSGASQTKPQIISSVGNPGDGTTKDSANKSISMTDMYLDSTDPSENVGQIHFSLEYDFQNTT 163
            |:|.:...:.:|.:.....|..:|..:|..::               :.:|:::|.|||||.:.:
  Fly   159 LLGSAYKEKVQPDMEELTENAEEGDEEDKQSE---------------QKLGRLNFKLEYDFNSNS 208

  Fly   164 LILKVLQGKELPAKDLSGTSDPYVRVTLLPDKKHRLETKIKRRTLNPRWNETFYFEGFPIQKLQS 228
            |.:.|:|.:||||.|:.|||||||:|.||||||.:.|||:.|:||:|.:||||.|:..|.....:
  Fly   209 LAVTVIQAEELPALDMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMN 273

  Fly   229 RVLHLHVFDYDRFSRDDSIGEVFLPLCQVDFAGKQSFWKAL----KPPAKDKCGELLSSLCYHPS 289
            :.|...:||:||||:.|.||||.:|||.:|.|.....|:.|    ....::|.|::..||.|.|:
  Fly   274 KTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDLVSVEGEGGQEKLGDICFSLRYVPT 338

  Fly   290 NSILTLTLIKARNLKAKDINGKSDPYVKVWLQFGDKRVEKRKTPIFTCTLNPVFNESFSFNVPWE 354
            ...||:.:::|:|||..|:.|.||||||:.:....||::|:||.|..|||||.:||||||.||:|
  Fly   339 AGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFE 403

  Fly   355 KIRECSLDVMVMDFDNIGRNELIGRILLAGKNGSGASETKHWQDMISKPRQTVVQWHRLK-PE 416
            :|::..|.|.|:|:|.||.:|.|||.:| |..|:| :|.:||.||::.||:.:.|||.|| ||
  Fly   404 QIQKICLVVTVVDYDRIGTSEPIGRCIL-GCMGTG-TELRHWSDMLASPRRPIAQWHTLKDPE 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt7	NP_726557.3	C2A_Synaptotagmin-7	147..271	CDD:176032	61/127 (48%)
Syt7	NP_726557.3	C2B_Synaptotagmin-7	277..414	CDD:176050	65/136 (48%)
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	61/123 (50%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	65/136 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468156
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		mtm1065
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10024
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
	7	6.950