DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt7 and Rph

DIOPT Version :9

Sequence 1:	NP_726557.3	Gene:	Syt7 / 43783	FlyBaseID:	FBgn0039900	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_572651.1	Gene:	Rph / 32002	FlyBaseID:	FBgn0030230	Length:	638	Species:	Drosophila melanogaster

Alignment Length:	444	Identity:	107/444 - (24%)
Similarity:	181/444 - (40%)	Gaps:	89/444 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 DEESSSYSLRAAQDIVDSGNPPTKPQVPVAHAI----------TTPLQNNINRKLNGFLSLRTPL 99
            |..|||......:|.||:|       |.:...:          :|.||...:.:|..:.|:|:.:
  Fly   208 DSSSSSSGHSEPEDEVDTG-------VGIGVGVVGGGMAKGIASTRLQREDSFRLRAYGSIRSFI 265

  Fly   100 IGG------------------------SGASQTKPQ---------IISSVGNPGDGTTKDSANKS 131
            .||                        ...|.:|.:         .:||..:..|.:...|.|..
  Fly   266 DGGERKLSNSFFFNRQQSQRPSECPEYDSVSMSKLRRESSFLRRGSVSSSWSISDSSGSGSNNSG 330

  Fly   132 ISMT---------DMYLDSTDPSENVGQIHFSLEYDFQNTTLILKVLQGKELPAKDLSGTSDPYV 187
            .|.|         .:.....||.  :|.:..::.|.....:|...:::.::|||.|.:|.:|||.
  Fly   331 NSQTQSQYQQHQQQLQQHCRDPL--LGWLEIAISYREAFHSLDCTMVRARDLPAMDAAGLADPYC 393

  Fly   188 RVTLLPDKKHRLETKIKR-----RTLNPRWNETFYFEGFPIQKLQSRVLHLHVFDYDRFSRDDSI 247
            ::.::..:.|...|:.:|     :|.||.:|||..|.|...::|.:.::::.:||      ||..
  Fly   394 KLNIITPEAHTKYTRWQRTKTVHKTRNPEFNETLQFVGVEPEELGNSLIYVALFD------DDKY 452

  Fly   248 GEVFL---PLC------------QVDFAGKQSFWKALKPPAKDKCGELLSSLCYHPSNSILTLTL 297
            |..||   .:|            .|....:..:..|.:.......|::|.||||:.....|.:.:
  Fly   453 GHDFLGAAKVCLSTVHSTSQYRISVPLGVEDQYSNAAEMAQNWPNGKMLLSLCYNTKRRALVVNV 517

  Fly   298 IKARNLKAKDINGKSDPYVKVWLQFGDKRVEKRKTPIFTCTLNPVFNESFSFNVPWEKIRECSLD 362
            .:..||.|.|.||.|||:||:.|:....:.:|.||.:...||||::||.|.|......:.:..|.
  Fly   518 KQCINLMAMDNNGSSDPFVKIQLKPDAHKNKKHKTSVKWRTLNPIYNEEFYFEASPHDLNKEMLI 582

  Fly   363 VMVMDFDNIGRNELIGRILLAGKNGSGASETKHWQDMISKPRQTVVQWHRLKPE 416
            :.|.|.|....|:.:|.:.|..:  |.....:.|.|.|..|.....:||.|.|:
  Fly   583 LTVWDKDLGKSNDFLGSLQLGAQ--SKGERLQQWLDCIRLPDHFHEKWHCLAPD 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt7	NP_726557.3	C2A_Synaptotagmin-7	147..271	CDD:176032	33/143 (23%)
Syt7	NP_726557.3	C2B_Synaptotagmin-7	277..414	CDD:176050	44/136 (32%)
Rph	NP_572651.1	PHD_SF	84..172	CDD:304600
		C2A_Rabphilin_Doc2	354..477	CDD:176000	31/128 (24%)
		C2B_Rabphilin_Doc2	499..631	CDD:176030	43/133 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468145
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	1	1.000	-	-		mtm1065
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
	5	4.840