DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt7 and Sytl1

DIOPT Version :9

Sequence 1:	NP_726557.3	Gene:	Syt7 / 43783	FlyBaseID:	FBgn0039900	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_113570.2	Gene:	Sytl1 / 269589	MGIID:	1933365	Length:	568	Species:	Mus musculus

Alignment Length:	411	Identity:	107/411 - (26%)
Similarity:	187/411 - (45%)	Gaps:	58/411 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 KRSQLQFIEPNEDE-ESSSYSLRAAQDIVDSGNPPTKP-QVPVAHAITTPLQNNINRKLNGFLSL 95
            |.|:.|..||.:.| |..:......|  |...:|...| |.....:..||.|:....|:
Mouse   166 KASEGQEEEPQDQECELEAPGEGGVQ--VAEADPELDPEQKAEQESQPTPAQSKATSKI------ 222

  Fly    96 RTPLIGGSGASQTKPQIISSVGNPGDGTTKDSANKSISMTDMYLDSTDPSENV-GQIHFSLEYDF 159
               |..|..|....|.:...:.:....::.:|:..|.|:..:..::...:..| |.:.|||.|:.
Mouse   223 ---LENGEEAPGLGPSLDRMLSSSSSVSSLNSSTLSGSLMSLSGEAEAGTVQVRGSVLFSLRYEP 284

  Fly   160 QNTTLILKVLQGKELPAKDLSGTSDPYVRVTLLPDKKHRLETKIKRRTLNPRWNETFYFEGFPIQ 224
            ..:.|.::|:|.:.|.|. ....|||||:..|||||:.:.:|.:|:|.|||.:|||....   :|
Mouse   285 GTSELRVQVIQCQGLAAA-RRRRSDPYVKSYLLPDKQSKRKTSVKKRNLNPIFNETLRHS---VQ 345

  Fly   225 K--LQSRVLHLHVFDYDRFSRDDSIGEVFLPLCQVDFAGKQSFWKALK---PPAKDKC---GELL 281
            :  |..|||.|.|:..:...|:..:|||.:||...:: ..::.|..|:   ||:.|:.   |.|.
Mouse   346 QADLPGRVLSLSVWHRESLGRNIFLGEVEVPLDTWNW-DSEATWLPLQPRVPPSPDELPSRGLLS 409

  Fly   282 SSLCYHPSNS---------ILTLTLIKARNLKAKDINGKSDPYVKVWLQFGDKRVEKRKTPIFTC 337
            .||.|.|:.|         .|...:.:|::|.... .|..|.|::..:...|.|..:::|.:...
Mouse   410 LSLKYVPAGSEGGGQPQSGELHFWVKEAQSLVPLR-PGSLDTYIQCSVLPDDSRASRQRTRVVRR 473

  Fly   338 TLNPVFNESFSFN--VPWEKIRECSLDVMVMDFDNIGRNELIG-RILLAGKNGSGAS-------- 391
            :|:||||.:..::  .|.: :|:...::.:.|...:...:|.| |:.|    |:|:|
Mouse   474 SLSPVFNHTMVYDGFGPAD-LRQACAELSLWDHGALASRQLGGTRLSL----GTGSSYGLQVPWM 533

  Fly   392 -----ETKHWQDMISKPRQTV 407
                 |.:.||.::.:|.:.|
Mouse   534 DSTPEEKQLWQTLLERPCEWV 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt7	NP_726557.3	C2A_Synaptotagmin-7	147..271	CDD:176032	45/129 (35%)
Syt7	NP_726557.3	C2B_Synaptotagmin-7	277..414	CDD:176050	36/159 (23%)
Sytl1	NP_113570.2	PHD_SF	35..>99	CDD:389947
		NESP55	<92..230	CDD:115071	18/74 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..255		21/99 (21%)
		C2	273..392	CDD:387358	43/123 (35%)
		C2B_SLP_1-2-3-4	405..561	CDD:175987	36/156 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910