DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt7 and PLA2G4F

DIOPT Version :9

Sequence 1:	NP_726557.3	Gene:	Syt7 / 43783	FlyBaseID:	FBgn0039900	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_998765.3	Gene:	PLA2G4F / 255189	HGNCID:	27396	Length:	849	Species:	Homo sapiens

Alignment Length:	224	Identity:	51/224 - (22%)
Similarity:	80/224 - (35%)	Gaps:	61/224 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 YDFQNTTLILKVLQGKELPAKDLSGTSDPYVRVTLLPDKKHRLETKIKRRTLNPRWNETFYFEGF 221
            ||.|     :|||:...:...||...:|.||::.|........:|:|.....:|.|||||:::
Human    44 YDLQ-----VKVLRATNIRGTDLLSKADCYVQLWLPTASPSPAQTRIVANCSDPEWNETFHYQ-- 101

  Fly   222 PIQKLQSRVLHLHVFDYDRFSRDDSIGEVF--------------LPL-------CQVDFAGKQSF 265
             |......||.|.::|.|....|.....:|              .||       .||:|..::|
Human   102 -IHGAVKNVLELTLYDKDILGSDQLSLLLFDLRSLKCGQPHKHTFPLNHQDSQELQVEFVLEKS- 164

  Fly   266 WKALKPPAKDKCGELLSS--LCYHPSNSILTLTLIKARNLKAKDINGKSDPYVKVWLQFG----- 323
                :.||    .|::::  |..||        .::.:.....|.....:.|....||..
Human   165 ----QVPA----SEVITNGVLVAHP--------CLRIQGTLRGDGTAPREEYGSRQLQLAVPGAY 213

  Fly   324 --------DKRVEKRKTPIFTCTLNPVFN 344
                    ....|....|.||..:|||.:
Human   214 EKPQLLPLQPPTEPGLPPTFTFHVNPVLS 242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt7	NP_726557.3	C2A_Synaptotagmin-7	147..271	CDD:176032	34/134 (25%)
Syt7	NP_726557.3	C2B_Synaptotagmin-7	277..414	CDD:176050	15/83 (18%)
PLA2G4F	NP_998765.3	C2_cPLA2	46..163	CDD:176001	31/124 (25%)
		PLAc	295..791	CDD:214474
		cPLA2_Grp-IVB-IVD-IVE-IVF	303..845	CDD:132840
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910