DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt7 and RPH3A

DIOPT Version :9

Sequence 1:	NP_726557.3	Gene:	Syt7 / 43783	FlyBaseID:	FBgn0039900	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001137326.1	Gene:	RPH3A / 22895	HGNCID:	17056	Length:	694	Species:	Homo sapiens

Alignment Length:	407	Identity:	121/407 - (29%)
Similarity:	181/407 - (44%)	Gaps:	84/407 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 PPTKPQV-PVAHAITTPLQNNINRKLNGFLSLRTPLIGG------------SGASQTKPQIISSV 116
            |..||:| |.....|.|.:......:.|:     |.:|.            |.||...||..::.
Human   311 PDQKPEVAPSDPGTTAPPREERTGGVGGY-----PAVGAREDRMSHPSGPYSQASAAAPQPAAAR 370

  Fly   117 GNPGDGTTKDSANKSISMTDMYLDSTDPSENVGQIHFSLEYDFQNTTLILKVLQGKELPAKDLSG 181
            ..|.....::.||.        .|| |.:..:|.:.|||.||..|::|...:::.|.|...|.:|
Human   371 QPPPPEEEEEEANS--------YDS-DEATTLGALEFSLLYDQDNSSLQCTIIKAKGLKPMDSNG 426

  Fly   182 TSDPYVRVTLLP--DKKHRLETKIKRRTLNPRWNETFYFEGFPIQKLQSRVLHLHVFDYDRFSRD 244
            .:||||::.|||  .|.::|.||..|.|.||.||||..:.|...:.:|.:.|.:.|.|.|:|..:
Human   427 LADPYVKLHLLPGASKSNKLRTKTLRNTRNPIWNETLVYHGITDEDMQRKTLRISVCDEDKFGHN 491

  Fly   245 DSIGEVFLPLCQVDFAGKQSFWKALKP--------------PAK--------------------- 274
            :.|||....|            |.|||              |.|
Human   492 EFIGETRFSL------------KKLKPNQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVER 544

  Fly   275 ----DKCGELLSSLCYHPSNSILTLTLIKARNLKAKDINGKSDPYVKVWLQFGDKRVEKRKTPIF 335
                ::.|::|.||.|......|.:.:|:..:|.|.|.||.|||:||:||:....:..|.||.|.
Human   545 VGDIEERGKILVSLMYSTQQGGLIVGIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIK 609

  Fly   336 TCTLNPVFNESFSFNVPWEKIRECSLDVMVMDFDNIGR-NELIGRILLAGKNGSGASETKHWQDM 399
            ..||||.|||.|.:::....:.:.|||:.|.|:| ||: |:.||...| |.:..| ...|||.:.
Human   610 KKTLNPEFNEEFFYDIKHSDLAKKSLDISVWDYD-IGKSNDYIGGCQL-GISAKG-ERLKHWYEC 671

  Fly   400 ISKPRQTVVQWHRLKPE 416
            :....:.:.:||:|:.|
Human   672 LKNKDKKIERWHQLQNE 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt7	NP_726557.3	C2A_Synaptotagmin-7	147..271	CDD:176032	44/125 (35%)
Syt7	NP_726557.3	C2B_Synaptotagmin-7	277..414	CDD:176050	50/137 (36%)
RPH3A	NP_001137326.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		FYVE_RP3A	92..171	CDD:277301
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..388		20/90 (22%)
		C2A_Rabphilin_Doc2	393..516	CDD:176000	46/134 (34%)
		C2B_Rabphilin_Doc2	553..685	CDD:176030	49/134 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910