DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt7 and Syt2

DIOPT Version :9

Sequence 1:	NP_726557.3	Gene:	Syt7 / 43783	FlyBaseID:	FBgn0039900	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001342655.1	Gene:	Syt2 / 20980	MGIID:	99666	Length:	422	Species:	Mus musculus

Alignment Length:	298	Identity:	136/298 - (45%)
Similarity:	198/298 - (66%)	Gaps:	6/298 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 GTTKDSANKSISMTDMYLDSTDPSENVGQIHFSLEYDFQNTTLILKVLQGKELPAKDLSGTSDPY 186
            |...|.|...::..:...:.....||:|::.|||:||||...|.:.|||..||||.|:.||||||
Mouse   117 GQDDDDAETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPY 181

  Fly   187 VRVTLLPDKKHRLETKIKRRTLNPRWNETFYFEGFPIQKLQSRVLHLHVFDYDRFSRDDSIGEVF 251
            |:|.||||||.:.|||:.|:||||.:||||.|: .|.|:|..:.|.:.::|:||||:.|.||||.
Mouse   182 VKVFLLPDKKKKYETKVHRKTLNPAFNETFTFK-VPYQELGGKTLVMAIYDFDRFSKHDIIGEVK 245

  Fly   252 LPLCQVDFAGKQSFWKALKPPAK---DKCGELLSSLCYHPSNSILTLTLIKARNLKAKDINGKSD 313
            :|:..||.......|:.|:...|   :|.|::.:||.|.|:...||:.:::|:|||..|:.|.||
Mouse   246 VPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSD 310

  Fly   314 PYVKVWLQFGDKRVEKRKTPIFTCTLNPVFNESFSFNVPWEKIRECSLDVMVMDFDNIGRNELIG 378
            ||||:.|....||::|:||.:...||||.|||||||.:|:|:|::..:.|.|:|:|.:|:||.||
Mouse   311 PYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIG 375

  Fly   379 RILLAGKNGSGASETKHWQDMISKPRQTVVQWHRLKPE 416
            :|.: |.|.:| :|.:||.||::.||:.:.|||.||||
Mouse   376 KIFV-GSNATG-TELRHWSDMLANPRRPIAQWHSLKPE 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt7	NP_726557.3	C2A_Synaptotagmin-7	147..271	CDD:176032	64/123 (52%)
Syt7	NP_726557.3	C2B_Synaptotagmin-7	277..414	CDD:176050	62/136 (46%)
Syt2	NP_001342655.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
		Syt2_N	4..116	CDD:409249
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	102..141		3/23 (13%)
		Phospholipid binding. /evidence=ECO:0000305	136..382		117/247 (47%)
		C2A_Synaptotagmin-1-5-6-9-10	142..264	CDD:176031	63/122 (52%)
		C2B_Synaptotagmin-1	274..409	CDD:176047	62/136 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910