DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt7 and Rph3a

DIOPT Version :9

Sequence 1:	NP_726557.3	Gene:	Syt7 / 43783	FlyBaseID:	FBgn0039900	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	XP_011246487.1	Gene:	Rph3a / 19894	MGIID:	102788	Length:	684	Species:	Mus musculus

Alignment Length:	382	Identity:	112/382 - (29%)
Similarity:	174/382 - (45%)	Gaps:	52/382 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 PPTKPQVPVAHAITTPLQNNINRKLNGFLSLRTPLIGGSGASQTKPQIISSVGNPGDGTTKDSAN 129
            ||:.|..|.|.|                 ..|....|.:|..|..|...:.............|.
Mouse   319 PPSDPGYPGAVA-----------------PAREERTGPAGGFQAAPHTAAPYSQAAPARQPPPAE 366

  Fly   130 KSISMTDMYLDSTDPSENVGQIHFSLEYDFQNTTLILKVLQGKELPAKDLSGTSDPYVRVTLLP- 193
            :.....:.|  .:|.:..:|.:.|||.||..|:.|...:::.|.|...|.:|.:||||::.|||
Mouse   367 EEEEEANSY--DSDEATTLGALEFSLLYDQDNSNLQCTIIRAKGLKPMDSNGLADPYVKLHLLPG 429

  Fly   194 -DKKHRLETKIKRRTLNPRWNETFYFEGFPIQKLQSRVLHLHVFDYDRFSRDDSIGEVFLPLCQV 257
             .|.::|.||..|.|.||.||||..:.|...:.:|.:.|.:.|.|.|:|..::.|||....|.::
Mouse   430 ASKSNKLRTKTLRNTRNPVWNETLQYHGITEEDMQRKTLRISVCDEDKFGHNEFIGETRFSLKKL 494

  Fly   258 DFAGKQSFWKALKP--PAK-------------------------DKCGELLSSLCYHPSNSILTL 295
            ....:::|...|:.  |.|                         ::.|::|.||.|......|.:
Mouse   495 KANQRKNFNICLERVIPMKRAGTTGSARGMALYEEEQVERIGDIEERGKILVSLMYSTQQGGLIV 559

  Fly   296 TLIKARNLKAKDINGKSDPYVKVWLQFGDKRVEKRKTPIFTCTLNPVFNESFSFNVPWEKIRECS 360
            .:|:..:|.|.|.||.|||:||:||:....:..|.||.|...||||.|||.|.:::....:.:.|
Mouse   560 GIIRCVHLAAMDANGYSDPFVKLWLKPDMGKKAKHKTQIKKKTLNPEFNEEFFYDIKHSDLAKKS 624

  Fly   361 LDVMVMDFDNIGR-NELIGRILLAGKNGSGASETKHWQDMISKPRQTVVQWHRLKPE 416
            ||:.|.|:| ||: |:.||...| |.:..| ...|||.:.:....:.:.:||:|:.|
Mouse   625 LDISVWDYD-IGKSNDYIGGCQL-GISAKG-ERLKHWYECLKNKDKKIERWHQLQNE 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt7	NP_726557.3	C2A_Synaptotagmin-7	147..271	CDD:176032	44/125 (35%)
Syt7	NP_726557.3	C2B_Synaptotagmin-7	277..414	CDD:176050	50/137 (36%)
Rph3a	XP_011246487.1	FYVE_RP3A	88..168	CDD:277301
		PRK07764	<175..352	CDD:236090	11/49 (22%)
		C2A_Rabphilin_Doc2	383..506	CDD:176000	43/122 (35%)
		C2B_Rabphilin_Doc2	543..675	CDD:176030	49/134 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910