Protein Alignment Syt7 and Doc2a

DIOPT Version :10

• Sequence 1: NP_726557.3
• Gene: Syt7 / 43783
• FlyBaseID: FBgn0039900
• Length: 416
• Species: Drosophila melanogaster
• Sequence 2: NP_034199.1
• Gene: Doc2a / 13446
• MGIID: 109446
• Length: 405
• Species: Mus musculus
• Alignment Length: 360
• Identity: 112/360 - (31%)
• Similarity: 168/360 - (46%)
• Gaps: 59/360 - (16%)

  Fly   101 GGSGASQ----------TKPQIISSVGNPGDGTTKDSANKSISMTDMYLDSTDPSENVGQIHFSL 155
            ||:|..:          ..|..:.....|.||...||           .||.|.:. :|.:.|.|
Mouse    50 GGTGCGEAPAHLAPLALAPPAALLGATTPDDGAEVDS-----------YDSDDTTA-LGTLEFDL 102

  Fly   156 EYDFQNTTLILKVLQGKELPAKDLSGTSDPYVRVTLLPD--KKHRLETKIKRRTLNPRWNETFYF 218
            .||..:..|..::|:.|.|...|.:|.:||||::.|||.  |.::|:||.:|.||||.|||...:
Mouse   103 LYDQASCMLHCRILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEELTY 167

  Fly   219 EGFPIQKLQSRVLHLHVFDYDRFSRDDSIGEVFLPL-------------C---QVDFAGKQSFWK 267
            .|.....:..:||.:.|.|.|:.|.::.|||:.:||             |   ||......|...
Mouse   168 SGITDDDITHKVLRISVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLPSPSSMSA 232

  Fly   268 ALK---------------PPAKDKCGELLSSLCYHPSNSILTLTLIKARNLKAKDINGKSDPYVK 317
            ||:               |...::.|.:|.||.|......|.:.:::..:|.|.|:||.||||||
Mouse   233 ALRGISCYLKELEQAEQGPGLLEERGRILLSLSYSSRRHGLLVGIVRCAHLAAMDVNGYSDPYVK 297

  Fly   318 VWLQFGDKRVEKRKTPIFTCTLNPVFNESFSFNVPWEKIRECSLDVMVMDFDNIGR-NELIGRIL 381
            .:|:....:..|.||.:...||||.|||.|.:.:....:...:|:|.|.|:| ||: |:.||.:.
Mouse   298 TYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYD-IGKSNDFIGGVS 361

  Fly   382 LAGKNGSGASETKHWQDMISKPRQTVVQWHRLKPE 416
            | |....|.:: |||.|.:.:|...:.:||.|..|
Mouse   362 L-GPGARGEAQ-KHWNDCLHQPDTALERWHTLTSE 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt7	NP_726557.3	C2A_Synaptotagmin-7	147..271	CDD:176032	48/156 (31%)
		C2B_Synaptotagmin-7	277..414	CDD:176050	49/137 (36%)
Doc2a	NP_034199.1	Interaction with UNC13D and DYNLT1. /evidence=ECO:0000250	1..94		12/54 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..54		2/3 (67%)
		C2A_Rabphilin_Doc2	95..218	CDD:176000	42/122 (34%)
		Interaction with UNC13D. /evidence=ECO:0000250	220..405		57/178 (32%)
		C2B_Rabphilin_Doc2	259..391	CDD:176030	48/134 (36%)