Protein Alignment Syt7 and TC2N

DIOPT Version :10

• Sequence 1: NP_726557.3
• Gene: Syt7 / 43783
• FlyBaseID: FBgn0039900
• Length: 416
• Species: Drosophila melanogaster
• Sequence 2: NP_689545.2
• Gene: TC2N / 123036
• HGNCID: 19859
• Length: 490
• Species: Homo sapiens
• Alignment Length: 430
• Identity: 89/430 - (20%)
• Similarity: 172/430 - (40%)
• Gaps: 71/430 - (16%)

  Fly    36 QLQFIEPNEDEESS-----------SYSLRAAQDIVDSGNPPT----KPQVPVAH-----AITTP 80
            :|.:|:|...|..|           |:..|..:....|.:.|:    .|.....|     :...|
Human    81 KLSYIQPRTQETPSHLEELEGSARASFGDRKVELSSSSQHGPSYDVYNPFYMYQHISPDLSRRFP 145

  Fly    81 LQNNINRKLNGFLSLRTPLIGGS-GASQT-------------KPQIISSVGNPGDGTTK---DSA 128
            .::.:.|.......|||..:.|| |.|::             :...:|||  |...:::   ..:
Human   146 PRSEVKRLYGSVCDLRTNKLPGSPGLSKSMFDLTNSSQRFIQRHDSLSSV--PSSSSSRKNSQGS 208

  Fly   129 NKSISMTDMYLDSTDPSENVGQIHFSLEYDFQNTTLILKVLQGKEL---------PAKDLSGTSD 184
            |:|:....:..|..|    .|:::..|.|:.....:.:.|||.::|         |...:.|
Human   209 NRSLDTITLSGDERD----FGRLNVKLFYNSSVEQIWITVLQCRDLSWPSSYGDTPTVSIKG--- 266

  Fly   185 PYVRVTLLPDKKHRLETKIKRRTLNPRWNETFYFEGFPIQKLQSRVLHLHVFDYD-RFSRDDSIG 248
                :..||...| .::..|..:....:.|||.| ...:|.||:..|   ||... :..|..:||
Human   267 ----ILTLPKPVH-FKSSAKEGSNAIEFMETFVF-AIKLQNLQTVRL---VFKIQTQTPRKKTIG 322

  Fly   249 EVFLPLCQVDFAGKQSFWKALKPPAK-DKC-GELLSSLCYHPSNSILTLTLIKARNLKAKDINGK 311
            |..:.|..:. ..:..:...:.||:| ..| .||....|:...||.:.|.:::||.|.:......
Human   323 ECSMSLRTLS-TQEMDYSLDITPPSKISVCHAELELGTCFQAVNSRIQLQILEARYLPSSSTPLT 386

  Fly   312 SDPYVKVWLQFGDKRVEKRKTPIFTCTLNPV-FNESFSFNVPWEKIRECSLDVMVMDFDNIGRNE 375
            ...:|||.:....:.:.|:||.:...:...| :.|:..|.: .:..:|....:.:....::.|..
Human   387 LSFFVKVGMFSSGELIYKKKTRLLKASNGRVKWGETMIFPL-IQSEKEIVFLIKLYSRSSVRRKH 450

  Fly   376 LIGRILLAGKNGSGASETKHWQDMISKPRQTVVQWHRLKP 415
            .:|:|.:: ::.:.......|::.:..|.:.|::||:|.|
Human   451 FVGQIWIS-EDSNNIEAVNQWKETVINPEKVVIRWHKLNP 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt7	NP_726557.3	C2A_Synaptotagmin-7	147..271	CDD:176032	28/133 (21%)
		C2B_Synaptotagmin-7	277..414	CDD:176050	28/138 (20%)
TC2N	NP_689545.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	189..215		6/27 (22%)
		C2A_Tac2-N	240..342	CDD:176066	25/114 (22%)
		C2B_Tac2-N	353..487	CDD:176074	27/135 (20%)
		Nuclear localization signal. /evidence=ECO:0000255	447..449		0/1 (0%)