DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt7 and syt6a

DIOPT Version :9

Sequence 1:	NP_726557.3	Gene:	Syt7 / 43783	FlyBaseID:	FBgn0039900	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	XP_017209198.1	Gene:	syt6a / 100149310	ZFINID:	ZDB-GENE-090601-2	Length:	537	Species:	Danio rerio

Alignment Length:	470	Identity:	163/470 - (34%)
Similarity:	235/470 - (50%)	Gaps:	87/470 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VLIACLAILGLIITIALFLAGGYLW--WRHKRSQLQFIEPNEDEESSSYSLRAAQDIVDSGNPPT 67
            |:|.|  :|.|:: :|.|.:....|  ||:|..            |||.:..|..|......|..
Zfish    62 VIIVC--VLALLL-LASFGSWKLCWIPWRNKAL------------SSSSAALAPDDCPSPHIPSV 111

  Fly    68 KPQVPVAHAITTPLQNNINRKLNGFLSLRTPLIGGSGASQTKPQIISSV---------------- 116
            .|....:.|:.|..:......: |||.....:      |.|.|.|.:.|
Zfish   112 LPSPQPSEAMATEKEKYPMASM-GFLEAAVKI------SHTSPDIPAEVQLSMREHFLRRTQRMQ 169

  Fly   117 ---GNPGDGTTKDSANK---------SISMTDMYLDSTDPS------------------------ 145
               ..|...|...|..:         |:.:.|.|.....|:
Zfish   170 RQTTEPASSTRHSSFKRHLPRQMQVSSLDLGDDYDVDEQPTSIGRIKPELYKQMTTENDESANSK 234

  Fly   146 --ENVGQIHFSLEYDFQNTTLILKVLQGKELPAKDLSGTSDPYVRVTLLPDKKHRLETKIKRRTL 208
              :|.|:|:|||.||::|..|::|:|:..:||||||.|:|||||::.||||:|.:.:|::.|:||
Zfish   235 GGKNCGKINFSLRYDYENEMLLVKILKAFDLPAKDLCGSSDPYVKIYLLPDRKQKFQTRVHRKTL 299

  Fly   209 NPRWNETFYFEGFPIQKLQSRVLHLHVFDYDRFSRDDSIGEVFLP-LCQV-DFAGKQSFWKALKP 271
            ||.::|:|.|. .|..:|..|.|||.|||:|||||.|.||||.|. |.:| |.:.:.|.|:.::.
Zfish   300 NPTFDESFQFP-VPYDELAVRKLHLSVFDFDRFSRHDMIGEVILDNLFEVSDLSRETSIWRDIQY 363

  Fly   272 PAKDK--CGELLSSLCYHPSNSILTLTLIKARNLKAKDINGKSDPYVKVWLQFGDKRVEKRKTPI 334
            ...:.  .||::.||||.|:...||||:||.|||||.||.|.|||||||.|....:|::|:||..
Zfish   364 ATSESVDLGEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLICDGRRLKKKKTTT 428

  Fly   335 FTCTLNPVFNESFSFNVPWEKIRECSLDVMVMDFDNIGRNELIGRILL-AGKNGSGASETKHWQD 398
            ...||||.:||:..|::|.|.:.:.||.:.|||:|.:|.||:||...| .|..|.|..   ||.:
Zfish   429 KKNTLNPTYNEAIIFDIPPESMDQVSLHISVMDYDLVGHNEIIGVCRLGCGAEGLGRD---HWNE 490

  Fly   399 MISKPRQTVVQWHRL 413
            |::.||:.:..||.|
Zfish   491 MLAYPRKPIAHWHPL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt7	NP_726557.3	C2A_Synaptotagmin-7	147..271	CDD:176032	63/125 (50%)
Syt7	NP_726557.3	C2B_Synaptotagmin-7	277..414	CDD:176050	65/138 (47%)
syt6a	XP_017209198.1	C2A_Synaptotagmin-1-5-6-9-10	238..363	CDD:176031	63/125 (50%)
syt6a	XP_017209198.1	C2B_Synaptotagmin-3-5-6-9-10	372..505	CDD:176048	64/135 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920