DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt7 and PLA2G4B

DIOPT Version :9

Sequence 1:	NP_726557.3	Gene:	Syt7 / 43783	FlyBaseID:	FBgn0039900	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001108105.1	Gene:	PLA2G4B / 100137049	HGNCID:	9036	Length:	781	Species:	Homo sapiens

Alignment Length:	231	Identity:	64/231 - (27%)
Similarity:	100/231 - (43%)	Gaps:	61/231 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 LILKVLQGKELPAKDLSGTSDPYVRVTLLPDKKHRLETKIKRRTLNPRWNETFYFEGFPIQKLQS 228
            |.::|||...||:|||...||.||.:.|.....|||:|:..:.:.:|.||::|:|.   |.:...
Human    12 LTVRVLQAHRLPSKDLVTPSDCYVTLWLPTACSHRLQTRTVKNSSSPVWNQSFHFR---IHRQLK 73

  Fly   229 RVLHLHVFDYDRFSRDDSIGEVFLPLCQVDF------AG---KQSFWKALKPPAKDKCGEL---- 280
            .|:.|.|||.|..:.||       |:..|.|      ||   ::||  :|.|..:   |.|
Human    74 NVMELKVFDQDLVTGDD-------PVLSVLFDAGTLRAGEFRRESF--SLSPQGE---GRLEVEF 126

  Fly   281 -LSSLC----YHPSNSILTLTLIKARNLKAKDINGKSDPYVKVWLQFGDKRVEKRKTPIF---TC 337
             |.||.    :..||.:|.     ||.|....:..:         :.||::..:.:..:.   :|
Human   127 RLQSLADRGEWLVSNGVLV-----ARELSCLHVQLE---------ETGDQKSSEHRVQLVVPGSC 177

  Fly   338 TLNP----VFNESFSFNVP--WEKIRECSLDVMVMD 367
            . .|    |...:|.|:.|  ||:    .|.:.:.|
Human   178 E-GPQEASVGTGTFRFHCPACWEQ----ELSIRLQD 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt7	NP_726557.3	C2A_Synaptotagmin-7	147..271	CDD:176032	40/115 (35%)
Syt7	NP_726557.3	C2B_Synaptotagmin-7	277..414	CDD:176050	23/109 (21%)
PLA2G4B	NP_001108105.1	C2_cPLA2	11..130	CDD:176001	44/132 (33%)
PLA2G4B	NP_001108105.1	cPLA2_Grp-IVB-IVD-IVE-IVF	243..768	CDD:132840
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910