DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syt7 and syt3

DIOPT Version :9

Sequence 1:	NP_726557.3	Gene:	Syt7 / 43783	FlyBaseID:	FBgn0039900	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	XP_005164031.1	Gene:	syt3 / 100000615	ZFINID:	ZDB-GENE-090601-1	Length:	566	Species:	Danio rerio

Alignment Length:	408	Identity:	153/408 - (37%)
Similarity:	216/408 - (52%)	Gaps:	67/408 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 PNEDEESS-----SYSLRAAQDIVDSGNPPTKP---------QVPVAHA---ITT---PLQNNIN 86
            |.|.:|.|     ||...||...:...:|...|         .:|.||:   :||   |:.:
Zfish   166 PQEMQEHSYLDMDSYPNNAATLKLSQTSPELPPATEGGSAAKDLPNAHSQQQVTTRPKPMTH--- 227

  Fly    87 RKLNGFLSLRTPLIGGSGAS-------QTKPQIIS-SVGNPGDGTTKDSANKSISMTDMYLDSTD 143
                   .|.:|...|...|       |.||::.. ..|:.|||                    .
Zfish   228 -------QLSSPDFHGEEKSEQLTSIGQIKPELYRLRQGDQGDG--------------------K 265

  Fly   144 PSENVGQIHFSLEYDFQNTTLILKVLQGKELPAKDLSGTSDPYVRVTLLPDKKHRLETKIKRRTL 208
            ...|.|:|.|.|.|.|....|::|:|:..:|||||.:|.|||||::.||||:|.:.:||:.|:||
Zfish   266 QGNNCGKISFLLRYAFNTEQLVVKILKALDLPAKDANGFSDPYVKIYLLPDRKKKFQTKVHRKTL 330

  Fly   209 NPRWNETFYFEGFPIQKLQSRVLHLHVFDYDRFSRDDSIGEVFLPLCQVDFA---GKQSFWKALK 270
            ||.:||||.| |.|:.:|.:|.||..|:|:|||||.|.||:|.:... :||:   |::..|:.:.
Zfish   331 NPVFNETFQF-GVPLAELHARKLHFSVYDFDRFSRHDLIGQVVVDNL-LDFSEGTGEKPIWRDIV 393

  Fly   271 PPAKDKC--GELLSSLCYHPSNSILTLTLIKARNLKAKDINGKSDPYVKVWLQFGDKRVEKRKTP 333
            ....:|.  |||..||||.|:...||:|:|||.||||.|:.|.||||||..|....:|::||||.
Zfish   394 EGTAEKADLGELNFSLCYLPTAGRLTVTIIKATNLKAMDLTGFSDPYVKASLVCEGRRLKKRKTS 458

  Fly   334 IFTCTLNPVFNESFSFNVPWEKIRECSLDVMVMDFDNIGRNELIGRILLAGKNGSGASETKHWQD 398
            |...||||.:||:..|::|.|.|...||.:.|||:|.||.||:||...: |.:..|... :||..
Zfish   459 IKKNTLNPTYNEALVFDIPNENIESVSLIIAVMDYDCIGHNEVIGMCRM-GSDADGPGR-EHWTA 521

  Fly   399 MISKPRQTVVQWHRLKPE 416
            |::.||:.:..||:|..|
Zfish   522 MLANPRKPIEHWHQLVEE 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt7	NP_726557.3	C2A_Synaptotagmin-7	147..271	CDD:176032	59/126 (47%)
Syt7	NP_726557.3	C2B_Synaptotagmin-7	277..414	CDD:176050	64/138 (46%)
syt3	XP_005164031.1	C2A_Synaptotagmin-1-5-6-9-10	269..394	CDD:176031	59/126 (47%)
syt3	XP_005164031.1	C2B_Synaptotagmin-3-5-6-9-10	403..536	CDD:176048	64/134 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X85
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920