Protein Alignment NfI and NFIC

DIOPT Version :9

• Sequence 1: NP_995592.2
• Gene: NfI / 43782
• FlyBaseID: FBgn0042696
• Length: 766
• Species: Drosophila melanogaster
• Sequence 2: XP_016882323.1
• Gene: NFIC / 4782
• HGNCID: 7786
• Length: 565
• Species: Homo sapiens
• Alignment Length: 690
• Identity: 240/690 - (34%)
• Similarity: 307/690 - (44%)
• Gaps: 175/690 - (25%)

  Fly    27 QDEFHPFIEALLPYVKSFSYSWFNLQAAKRKYYKKHEKRMSLEEERHCKDELQNEKTEVKQKWAS 91
            |||||||||||||:|::|:|:||||||.||||:||||||||.:|||..||||..||.||||||||
Human    10 QDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWAS 74

  Fly    92 RLLGKLRKDITQESREDFVQSIIGKRKSICVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFK 156
            |||.||||||..|.|||||.||.||:...||||||||||||||||||||||||||||||||||||
Human    75 RLLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFK 139

  Fly   157 AIPLESTDGERLEKNPECLHPGLCVNPYHINVSVRELDLYLANFINTHNSINNTNTTFSTTPGVR 221
            .|||||||||||.|..:|.||.|||.|:||.|:|:|||||||.|:...::..:           .
Human   140 GIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDAEQS-----------G 193

  Fly   222 SPHITMYNRSND--PNRKDEVADMKNDVVKQNPYNGVVCNDIILATGVFSSQELWTLSKDLILDE 284
            ||...|.:...|  |...| ..|.:...|               .:||||..||..:|:..::..
Human   194 SPRTGMGSDQEDSKPITLD-TTDFQESFV---------------TSGVFSVTELIQVSRTPVVTG 242

  Fly   285 SNDINLNSSLIKRENVGATYECNTYQINSESSISAAQSLVQSGSIAANPIPLGYSIDFIDQRITQ 349
            :..   |.||      |.......|.:| .:|....::|..:.|..:.....|...:.:|
Human   243 TGP---NFSL------GELQGHLAYDLN-PASTGLRRTLPSTSSSGSKRHKSGSMEEDVD----- 292

  Fly   350 LSQSPLPRTEGPNGDSHDANKIDQSS------------SPPITSTASDNGTSSFSLIVRATDSSI 402
                     ..|.||.:.:.....||            |.|:..|..|.  |.|:     :.|..
Human   293 ---------TSPGGDYYTSPSSPTSSSRNWTEDMEGGISSPVKKTEMDK--SPFN-----SPSPQ 341

  Fly   403 EDPKTSPISLHRYTSLSSRTLAQALPQHSCSLLHSSSTS----------PTNTLYYPQHNNTRPS 457
            :.|:.|..:.|....::..:.....| |..|.||..:||          |...:.||.|.|
Human   342 DSPRLSSFTQHHRPVIAVHSGIARSP-HPSSALHFPTTSILPQTASTYFPHTAIRYPPHLN---- 401

  Fly   458 QTTSVEEQNRVGSDKYSTEPQD-ISDFVTYVCQDTSHTT-TITGSAENHSFQHSHTLPQGHGHSP 520
                               ||| :.|.|:..|...|... .:.||.:..  ..||.|
Human   402 -------------------PQDPLKDLVSLACDPASQQPGPLNGSGQLK--MPSHCL-------- 437

  Fly   521 HFQIHQQLRSAKLTTSPSTHYHSTMLPPMLPPMARPVAIIRSSSDLTLVQSPPTSLPLTAQSTSL 585
                     ||::...|         ||.||.:|.|.|...:::......||      |:.|.|.
Human   438 ---------SAQMLAPP---------PPGLPRLALPPATKPATTSEGGATSP------TSPSYSP 478

  Fly   586 NDNSCIAKHSLPTDNRLASNLDNRNSPNNTDVVSQHEMTGTASPQPQSHT-PTLASPQSYLDPGR 649
            .|.|...:..:....|..:.:....:|.|               ||:... ...|||:...||
Human   479 PDTSPANRSFVGLGPRDPAGIYQAQAPQN---------------QPEEEAGMEAASPEFRGDP-- 526

  Fly   650 CKLLSAGSNIG---RITTQMYPSSNNREYFNHFHSQPTSL 686
            |.:  .|.|.|   |...|.:.:          ||:|.||
Human   527 CAM--GGGNPGSGARAPAQCWLT----------HSEPLSL 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NfI	NP_995592.2	NfI_DNAbd_pre-N	25..64	CDD:287494	29/36 (81%)
		MH1	85..193	CDD:260161	85/107 (79%)
NFIC	XP_016882323.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160000
Domainoid	1	1.000	170	1.000	Domainoid score	I3771
eggNOG	1	0.900	-	-		E1_KOG3663
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2732
Isobase	1	0.950	-	0	Normalized mean entropy	S5305
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D411112at33208
OrthoFinder	1	1.000	-	-		FOG0000997
OrthoInspector	1	1.000	-	-		otm41885
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11492
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3993
SonicParanoid	1	1.000	-	-		X590
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.840