Protein Alignment NfI and NFIA

DIOPT Version :10

• Sequence 1: NP_995592.2
• Gene: NfI / 43782
• FlyBaseID: FBgn0042696
• Length: 766
• Species: Drosophila melanogaster
• Sequence 2: NP_001138984.1
• Gene: NFIA / 4774
• HGNCID: 7784
• Length: 554
• Species: Homo sapiens
• Alignment Length: 629
• Identity: 224/629 - (35%)
• Similarity: 298/629 - (47%)
• Gaps: 174/629 - (27%)

  Fly    27 QDEFHPFIEALLPYVKSFSYSWFNLQAAKRKYYKKHEKRMSLEEERHCKDELQNEKTEVKQKWAS 91
            |||||||||||||:|::|:|:||||||.||||:||||||||.||||..||||.:||.||||||||
Human    54 QDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWAS 118

  Fly    92 RLLGKLRKDITQESREDFVQSIIGKRKSICVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFK 156
            |||.||||||..|.|||||.::.||:...||||||||||||||||||||||||||||||||||||
Human   119 RLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFK 183

  Fly   157 AIPLESTDGERLEKNPECLHPGLCVNPYHINVSVRELDLYLANFINTHNSINNTNTTFSTTPGVR 221
            .|||||||||||.|:|:|.:|||||.|:||.|||:|||||||.|::..:|
Human   184 GIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAADS--------------- 233

  Fly   222 SPHITMYNRSNDPNRKDEVADMKNDVVKQNPYNG-VVCNDIILATGVFSSQELWTLSKDLI---- 281
                   ::|..|::..: ||     :|..|.|| :...|..:.:||||..||..:|:..|
Human   234 -------SQSESPSQPSD-AD-----IKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGT 285

  Fly   282 --------LDESNDINLNSSLIKRENVGATYECNTYQINSESSISAAQSLVQSGSIAANPIPLGY 338
                    |:.|:..:::...::|            .:.|.||.|:.:.|..
Human   286 GPNFSLSDLESSSYYSMSPGAMRR------------SLPSTSSTSSTKRLKS------------- 325

  Fly   339 SIDFIDQRITQLSQSPL----PRTEGPNGDSHDANKIDQSSSPPITSTASDNGTSSFSLIVRATD 399
                ::..:....:.|.    .|:.|....|...::::.....|.|...|:.  |.||
Human   326 ----VEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSPTTLKKSEK--SGFS------- 377

  Fly   400 SSIEDPKTSPISLHRYTSLSSRTLAQALPQHSCSLLHSSSTSP---TNTLYYPQHNNTRPSQTTS 461
                .|..|..|          :|..|..||...::.....||   .:||::|         |:.
Human   378 ----SPSPSQTS----------SLGTAFTQHHRPVITGPRASPHATPSTLHFP---------TSP 419

  Fly   462 VEEQNRVGSDKYSTEP-------QDISDFVTYVCQDTSHTTTITGSAENHSFQHSHTLPQGHGHS 519
            :.:|    ...|.:.|       :.:.:||..||.|........|      |.:.:...||..|:
Human   420 IIQQ----PGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVG------FLNPNGSSQGKVHN 474

  Fly   520 PHFQIHQQLRSAKLTTSPSTHYHSTML-PPMLPPMARPVAIIRSSSDLTLVQSPPTSLPLTAQST 583
            |...                   :.|| ||..|||||||               |..:|.|...|
Human   475 PFLP-------------------TPMLPPPPPPPMARPV---------------PLPVPDTKPPT 505

  Fly   584 SLNDNSCIAKHSLPTDNRLASNLDNR------------NSPNNT 615
            :..:... |..:.||.:..:::..||            |.|..|
Human   506 TSTEGGA-ASPTSPTYSTPSTSPANRFVSVGPRDPSFVNIPQQT 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NfI	NP_995592.2	NfI_DNAbd_pre-N	24..64	CDD:463134	29/36 (81%)
		MH1	85..193	CDD:469592	85/107 (79%)
NFIA	NP_001138984.1	NfI_DNAbd_pre-N	54..91	CDD:463134	29/36 (81%)
		MH1	113..217	CDD:460833	82/103 (80%)
		CTF_NFI	259..546	CDD:459967	75/392 (19%)