DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NfI and Nfib

DIOPT Version :9

Sequence 1:	NP_995592.2	Gene:	NfI / 43782	FlyBaseID:	FBgn0042696	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	XP_017448686.1	Gene:	Nfib / 29227	RGDID:	62015	Length:	634	Species:	Rattus norvegicus

Alignment Length:	626	Identity:	222/626 - (35%)
Similarity:	292/626 - (46%)	Gaps:	146/626 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 DEFHPFIEALLPYVKSFSYSWFNLQAAKRKYYKKHEKRMSLEEERHCKDELQNEKTEVKQKWASR 92
            ||||||||||||:|::.:|:||||||.||||:||||||||.:|||..||||.:||.|:|||||||
  Rat    75 DEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASR 139

  Fly    93 LLGKLRKDITQESREDFVQSIIGKRKSICVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKA 157
            ||.||||||.||.|||||.::.||:...|||||||||||:||||||||||||||||||||||||.
  Rat   140 LLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKG 204

  Fly   158 IPLESTDGERLEKNPECLHPGLCVNPYHINVSVRELDLYLANFINTHNSINNTNTTFSTTPGVRS 222
            |||||||||||.|:|.|.:|.|||.|:||.|||:||||:||.::...:|
  Rat   205 IPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDS---------------- 253

  Fly   223 PHITMYNRSNDPNRKDEVADMKNDVVKQNPYNGVVCNDIILATGVFSSQELWTLSKDLILDESND 287
                  .:|..|:.        ||..|..|  |.: .|..:.:|||:..||..:|:..| .:...
  Rat   254 ------GQSGSPSH--------NDPAKNPP--GYL-EDSFVKSGVFNVSELVRVSRTPI-TQGTG 300

  Fly   288 INLNSSLIKRENVGATYECNTYQINSESSISAAQSLVQSGSIAAN----PIPLGYSIDFIDQRIT 348
            :|.....|..:   ..|......:|.:.|:|:..|..:..:|:.:    |.|.|   ||
  Rat   301 VNFPIGEIPSQ---PYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG---DF------ 353

  Fly   349 QLSQSPLPRTEGPNGDSHDANKIDQSSSPPITSTASDNGTSSFSLIVRATDSSIEDPKTSPISLH 413
                  .|....|...|...::.||..|.|.|....:....|      :|......|:.|....|
  Rat   354 ------YPSPNSPAAGSRTWHERDQDMSSPTTMKKPEKPLFS------STSPQDSSPRLSTFPQH 406

  Fly   414 R--------YTSLSSRT--LAQALPQHSCSLLHSSSTSPTN--TLYYPQHNNTR-------PSQT 459
            .        ::.:|:||  ....||..:.::|..:.:|..:  |:.||.|.|.:       ||..
  Rat   407 HHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYD 471

  Fly   460 TSVEEQNRVGSDKY---------------STEPQDISDFVTYVCQDTSHTTTITGSAENHSFQHS 509
            .|..:.::..|...               |..|..:.. ||....||...||   |.|..:...:
  Rat   472 PSSPQTSQPNSSGQVVGKVPGHFTPVLAPSPHPSAVRP-VTLTMTDTKPITT---STEGEAASPT 532

  Fly   510 HTLPQGHGHS------------PHFQIHQQLRSAKLTTSPSTHYHSTMLPPMLPPMARPVAIIRS 562
            .|.....|.|            |.|...||||....|.:.:..:                 :..|
  Rat   533 ATTYTASGTSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRH-----------------LYPS 580

  Fly   563 SSDLTL---VQSPPT--------------SLPLTAQSTSLN 586
            :|:.||   .|||.|              .||...|:..||
  Rat   581 TSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYGLN 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NfI	NP_995592.2	NfI_DNAbd_pre-N	25..64	CDD:287494	27/35 (77%)
NfI	NP_995592.2	MH1	85..193	CDD:260161	83/107 (78%)
Nfib	XP_017448686.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354066
Domainoid	1	1.000	170	1.000	Domainoid score	I3661
eggNOG	1	0.900	-	-		E1_KOG3663
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2636
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D411112at33208
OrthoFinder	1	1.000	-	-		FOG0000997
OrthoInspector	1	1.000	-	-		otm46022
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11492
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X590
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.990