DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NfI and Nfia

DIOPT Version :9

Sequence 1:	NP_995592.2	Gene:	NfI / 43782	FlyBaseID:	FBgn0042696	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	NP_037120.1	Gene:	Nfia / 25492	RGDID:	3170	Length:	509	Species:	Rattus norvegicus

Alignment Length:	629	Identity:	224/629 - (35%)
Similarity:	298/629 - (47%)	Gaps:	174/629 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 QDEFHPFIEALLPYVKSFSYSWFNLQAAKRKYYKKHEKRMSLEEERHCKDELQNEKTEVKQKWAS 91
            |||||||||||||:|::|:|:||||||.||||:||||||||.||||..||||.:||.||||||||
  Rat     9 QDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWAS 73

  Fly    92 RLLGKLRKDITQESREDFVQSIIGKRKSICVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFK 156
            |||.||||||..|.|||||.::.||:...||||||||||||||||||||||||||||||||||||
  Rat    74 RLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFK 138

  Fly   157 AIPLESTDGERLEKNPECLHPGLCVNPYHINVSVRELDLYLANFINTHNSINNTNTTFSTTPGVR 221
            .|||||||||||.|:|:|.:|||||.|:||.|||:|||||||.|::..:|
  Rat   139 GIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAADS--------------- 188

  Fly   222 SPHITMYNRSNDPNRKDEVADMKNDVVKQNPYNG-VVCNDIILATGVFSSQELWTLSKDLI---- 281
                   ::|..|::..: ||     :|..|.|| :...|..:.:||||..||..:|:..|
  Rat   189 -------SQSESPSQPSD-AD-----IKDQPENGHLGFQDSFVTSGVFSVTELVRVSQTPIAAGT 240

  Fly   282 --------LDESNDINLNSSLIKRENVGATYECNTYQINSESSISAAQSLVQSGSIAANPIPLGY 338
                    |:.|:..:::...::|            .:.|.||.|:.:.|..
  Rat   241 GPNFSLSDLESSSYYSMSPGAMRR------------SLPSTSSTSSTKRLKS------------- 280

  Fly   339 SIDFIDQRITQLSQSPL----PRTEGPNGDSHDANKIDQSSSPPITSTASDNGTSSFSLIVRATD 399
                ::..:....:.|.    .|:.|....|...::::.....|.|...|:.  |.||
  Rat   281 ----VEDEMDSPGEEPFYTGQGRSPGSGSQSSGWHEVEPGMPSPTTLKKSEK--SGFS------- 332

  Fly   400 SSIEDPKTSPISLHRYTSLSSRTLAQALPQHSCSLLHSSSTSP---TNTLYYPQHNNTRPSQTTS 461
                .|..|..|          :|..|..||...::.....||   .:||::|         |:.
  Rat   333 ----SPSPSQTS----------SLGTAFTQHHRPVITGPRASPHATPSTLHFP---------TSP 374

  Fly   462 VEEQNRVGSDKYSTEP-------QDISDFVTYVCQDTSHTTTITGSAENHSFQHSHTLPQGHGHS 519
            :.:|    ...|.:.|       :.:.:||..||.|........|      |.:.:...||..|:
  Rat   375 IIQQ----PGPYFSHPAIRYHPQETLKEFVQLVCPDAGQQAGQVG------FLNPNGSSQGKVHN 429

  Fly   520 PHFQIHQQLRSAKLTTSPSTHYHSTML-PPMLPPMARPVAIIRSSSDLTLVQSPPTSLPLTAQST 583
            |...                   :.|| ||..|||||||               |..:|.|...|
  Rat   430 PFLP-------------------TPMLPPPPPPPMARPV---------------PLPMPDTKPPT 460

  Fly   584 SLNDNSCIAKHSLPTDNRLASNLDNR------------NSPNNT 615
            :..:... |..:.||.:..:::..||            |.|..|
  Rat   461 TSTEGGA-ASPTSPTYSTPSTSPANRFVSVGPRDPSFVNIPQQT 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NfI	NP_995592.2	NfI_DNAbd_pre-N	25..64	CDD:287494	29/36 (81%)
NfI	NP_995592.2	MH1	85..193	CDD:260161	85/107 (79%)
Nfia	NP_037120.1	NfI_DNAbd_pre-N	9..46	CDD:371114	29/36 (81%)
		MH1	68..172	CDD:412134	82/103 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..211		8/27 (30%)
		CTF_NFI	214..508	CDD:395689	77/396 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..345		20/137 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	352..371		4/18 (22%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:Q12857	394..402		2/7 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	437..509		22/83 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354067
Domainoid	1	1.000	170	1.000	Domainoid score	I3661
eggNOG	1	0.900	-	-		E1_KOG3663
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2636
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D411112at33208
OrthoFinder	1	1.000	-	-		FOG0000997
OrthoInspector	1	1.000	-	-		otm46022
orthoMCL	1	0.900	-	-		OOG6_106071
Panther	1	1.100	-	-	LDO	PTHR11492
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X590
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.800