DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP102A and ARHGAP11A

DIOPT Version :9

Sequence 1:	NP_001245416.1	Gene:	RhoGAP102A / 43781	FlyBaseID:	FBgn0259216	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_055598.1	Gene:	ARHGAP11A / 9824	HGNCID:	15783	Length:	1023	Species:	Homo sapiens

Alignment Length:	439	Identity:	115/439 - (26%)
Similarity:	174/439 - (39%)	Gaps:	114/439 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   826 EYGSTELSAYVRGSFSNISKPLASLSQSENEDTELNFVKAYQEHSQLMVPIFVNNCIDYLEDNGL 890
            |..:||:...:.|      .|..:|..|           |..|:..  :|.|:.:....|||: :
Human    36 ETAATEIGGKIFG------VPFNALPHS-----------AVPEYGH--IPSFLVDACTSLEDH-I 80

  Fly   891 QQVGLFRVSTSKKRVKQLREEFDKDIYFGISVDTCPHDVATLLKEFLRDLPEPLLCNTLYLTFLK 955
            ...||||.|.|..|:|.|:.:.|..  .|......|.|:|.|||:|.|:||||:|...|:...||
Human    81 HTEGLFRKSGSVIRLKALKNKVDHG--EGCLSSAPPCDIAGLLKQFFRELPEPILPADLHEALLK 143

  Fly   956 TQRIRNRRLQLEAISHLIRLLPIPHRDTLYVL---LVFLAKVAAHSDDIWSTEGCCLTLGNKMDS 1017
            .|::.........:  |:..|...|  |::||   ..||..|:..|.:            |||||
Human   144 AQQLGTEEKNKATL--LLSCLLADH--TVHVLRYFFNFLRNVSLRSSE------------NKMDS 192

  Fly  1018 YNLATVFAPNILRST--HLTFSRDKEQENMIDAINVVRTMINHYEEIFNISAELLNVI------- 1073
            .|||.:||||:|:::  |...|.:.|::..:.|. ||:|:|::..:|..:...:|..|
Human   193 SNLAVIFAPNLLQTSEGHEKMSSNTEKKLRLQAA-VVQTLIDYASDIGRVPDFILEKIPAMLGID 256

  Fly  1074 ---YTQALEACPEKLYELISTKVYGTEWTQQQIDDPQPGSL-----------------------S 1112
               .|.:||...|..||   |........:|.:.|...|:|                       |
Human   257 GLCATPSLEGFEEGEYE---TPGEYKRKRRQSVGDFVSGALNKFKPNRTPSITPQEERIAQLSES 318

  Fly  1113 DVLLEPPIHGKRYENINDFNNINFKRCQDKRRDHSDPDKKK---NNNENLEIITASL--KISVAE 1172
            .|:|.|                |.||.......|....||:   .:|.|.|::.::|  ..|...
Human   319 PVILTP----------------NAKRTLPVDSSHGFSSKKRKSIKHNFNFELLPSNLFNSSSTPV 367

  Fly  1173 QSHISLKEPIKEQEPITSYKQFSRSTLPTSISDVGVNTLRTDGAKLENK 1221
            ..||.           ||.:..|:|:|...:  :|.|.|.|.|....:|
Human   368 SVHID-----------TSSEGSSQSSLSPVL--IGGNHLITAGVPRRSK 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP102A	NP_001245416.1	RhoGAP	874..1069	CDD:295372	65/199 (33%)
ARHGAP11A	NP_055598.1	RhoGAP-ARHGAP11A	46..246	CDD:239859	71/238 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	567..589
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	714..734
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	999..1023
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2710
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810